Randomized trial Food & function · 2026 Efficacy of Bifidobacterium animalis subsp. lactate BL-99 in relieving functional constipation: a randomized placebo-controlled clinical trial. Shao J, Hung W, Yin P, et al. Bifidobacterium animalisClostridiumFaecalibacterium PubMed ↗
Observational Medicine · 2026 Gut microbiota alterations and their correlation with constipation in older adults with Alzheimer's disease or mild cognitive impairment: A cross-sectional study. Huang KY, Wei YY, Zhang ST, et al. Lachnospira PubMed ↗
Randomized trial Journal of diabetes investigation · 2026 Effects of age, sex, and renal function on bowel movement-improving effects of Bifidobacterium bifidum G9-1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study. Ikeda F, Sato J, Yoshii H, et al. Bifidobacterium bifidum PubMed ↗
Observational Clinical interventions in aging · 2026 Gut Microbiota in Constipation and Mild Cognitive Impairment: A Mendelian Randomization and Observational Study of Two Common Geriatric Syndromes. Ren Q, Zhang J, Liu Y, et al. EnterococcusEscherichiaOscillibacterPrevotella PubMed ↗
Randomized trial European journal of nutrition · 2026 The effectiveness of a plant-based milk with fermented brown rice on constipation symptoms via gut microbiota modulation: a double-blind randomized controlled trial. Tang A, Cao Q, Wang M, et al. Blautia PubMed ↗
Randomized trial Nutrients · 2026 A Heat-Inactivated Two-Strain Lacticaseibacillus paracasei Fermented Milk as a Postbiotic for Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial. Li X, Lan H, Guan Y, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Clinical nutrition · 2026 Effects of early postoperative synbiotic supplementation on gastrointestinal outcomes after sleeve gastrectomy: A randomized controlled trial. Altunsaray A, Dağ B, Dağ A Lacticaseibacillus rhamnosus PubMed ↗
Observational Nutrition · 2026 Associations of dietary diversity with constipation symptoms and gut microbiota features in individuals with functional constipation. Tang A, Tian T, Li W, et al. [Ruminococcus] torques PubMed ↗
Randomized trial Biotechnology journal · 2026 Synbiotic Supplementation With Heyndrickxia coagulans TBC169 Improves Chronic Constipation in Middle-Aged and Elderly. Zhou X, Guo C, Hu G, et al. Heyndrickxia coagulansAkkermansiaBlautiaCollinsella +1 more PubMed ↗
Randomized trial Medicine · 2026 Probiotics for chronic constipation: A randomized, prospective, placebo-controlled study. Porwal AD, Gandhi PM, Kulkarni DK, et al. Bifidobacterium PubMed ↗
Randomized trial Biotechnology journal · 2026 Lactiplantibacillus plantarum Z6 Improves Functional Constipation in Infants. Zhou X, Hu G, Wu J, et al. Lactiplantibacillus plantarumBifidobacteriumGemmigerStreptococcus PubMed ↗
Randomized trial PloS one · 2026 Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: A randomized, double-blind, placebo-controlled trial. Park HG, Lee HB, Lee M, et al. Bacillus subtilisClostridium butyricumHeyndrickxia coagulans PubMed ↗
Randomized trial Diabetes, obesity & metabolism · 2026 Bifidobacterium bifidum G9-1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open-Label, Randomized Controlled Trial (Binary STAR Study). Kobayashi G, Hashimoto Y, Matsuyama T, et al. Bifidobacterium bifidumPhocaeicola PubMed ↗
Randomized trial Journal of ethnopharmacology · 2026 The adjunct use of Bifidobacterium animalis subsp. lactis BAMA-B06/BAu-B0111 improves the therapeutic efficacy of Liuwei'anxiao Capsule in alleviating constipation in Parkinson's Disease: A randomized controlled study. Lin M, Li S, Lin J, et al. Bifidobacterium animalisRoseburia PubMed ↗
Randomized trial European journal of nutrition · 2026 Weizmannia coagulans BC99 improved intestinal motility and chronic constipation through regulating gut microbiota: a randomized, double-blind, placebo-controlled trial. Wu Y, Zhou Y, Fan Q, et al. Heyndrickxia coagulansBifidobacteriumEscherichia PubMed ↗
Clinical trial Minerva gastroenterology · 2026 Efficacy of a probiotic-prebiotic mix on chronic constipation symptoms in the elderly: results of a pilot study. Montarsolo P, Barbagallo S, Fioravanti P, et al. Bifidobacterium animalisBifidobacterium breveLacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Clinical nutrition · 2026 A multi-strain probiotic formulation alleviates chronic constipation in middle-aged and older adults: A randomized, double-blind, placebo-controlled trial. Xiao R, He Y, Mao X, et al. BifidobacteriumCollinsellaFaecalibacteriumOscillibacter PubMed ↗
Clinical trial Journal of diabetes investigation · 2026 Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study). Ikeda F, Sato J, Yoshii H, et al. Bifidobacterium bifidum PubMed ↗
Clinical trial Journal of microbiology and biotechnology · 2025 Pilot Clinical Trial of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease. Zhang H, Shen C, Lei W, et al. AlistipesAnaerotruncusFlavonifractor PubMed ↗
Randomized trial Medicine · 2025 Weizmannia coagulans BC01 supplementation improved functional constipation by regulating gut microbiota: A randomized, placebo-controlled, clinical study. Xu Y, Zhang Y, Yue F, et al. Heyndrickxia coagulansBacteroidesBifidobacteriumBlautia +1 more PubMed ↗
Systematic review Indian journal of gastroenterology · 2025 Altered molecular signature of the intestinal microbiota in irritable bowel syndrome patients versus healthy controls: An updated systematic review. Wang ZZ, Chen YK, Li X, et al. Butyricimonas PubMed ↗
Review Clinical nutrition ESPEN · 2025 Dietary management of functional constipation in disorders of gut-brain interaction - A scoping review. Quan V, Carey S Bifidobacterium PubMed ↗
Review Current opinion in clinical nutrition and metabolic care · 2025 An update on probiotics in paediatrics. Zemła M, Kotowska-Bąbol M, Szajewska H Bifidobacterium animalisLacticaseibacillus rhamnosusLimosilactobacillus reuteriSaccharomyces cerevisiae +1 more PubMed ↗
Randomized trial BMC gastroenterology · 2025 Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of a randomized, double-blind, placebo-controlled study. Puhlmann ML, Wegh CAM, van der Zalm SCC, et al. AnaerostipesCoprococcusFaecalibacteriumRoseburia PubMed ↗
Randomized trial Complementary therapies in medicine · 2025 Brain-gut-microbiota axis: An effective target of abdominal acupuncture therapy for post-stroke functional constipation. Li S, Wang S, Li S, et al. Enterococcus PubMed ↗
Randomized trial Movement disorders · 2025 Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial. Leta V, Zinzalias P, Batzu L, et al. Enterococcus faeciumLacticaseibacillus rhamnosusLactiplantibacillus plantarumLactobacillus acidophilus +1 more PubMed ↗
Review British journal of hospital medicine · 2025 The Role of Colonic Microbiota in Constipation Predominant Irritable Bowel Syndrome: A Literature Review. Roy YJ, Mirani Y, Raju J, et al. Escherichia coli PubMed ↗
Randomized trial European journal of nutrition · 2025 Effects of konjac glucomannan on gastrointestinal symptoms and gut microbiota in athletes with functional constipation: a double-blind randomized controlled trial. Zhu Y, Chen X, Song G AlistipesDesulfovibrioPhascolarctobacterium PubMed ↗
Observational Nutrition · 2025 Gut microbiota biomarkers enable stratified nutritional approaches for functional constipation subtypes in children with comorbidities. Huang C, Wang C, Wu B, et al. Clostridium butyricumBlautiaEnterococcusFaecalibacterium +2 more PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2025 Impact of prebiotics and postbiotics in the management of constipation: Analysis of their differentiated modulation of intestinal microbiota. Culqui Lévano DR, Rodríguez Sanz P, Palacios Sanchez R, et al. [Clostridium] leptumBifidobacterium longumBlautia obeumCollinsella aerofaciens +3 more PubMed ↗
Observational Digestive and liver disease · 2025 Multiomics insights into functional constipation: Exploring microbiome, metabolome, and lipidome independent of transit time. Ryu JE, Shin SY, Ahn JS, et al. Blautia faecisBlautia wexleraeCollinsella aerofaciensFusicatenibacter saccharivorans PubMed ↗
Randomized trial Beneficial microbes · 2025 The impact of Bifidobacterium longum CCFM1112 on chronic constipation: a randomised, double-blind, placebo-controlled study. Liu W, Wang J, Xue Y, et al. Bifidobacterium longumAnaerobutyricum halliiStreptococcus salivariusBlautia PubMed ↗
Review Molecular nutrition & food research · 2025 Bottom-Up Design of Prebiotics and Probiotics: An Intestinal Microbiota-Centered Approach to Chronic and Functional Constipation Management. He P, Chen S, Lyu C, et al. Dorea formicigeneransEubacterium ramulusAlistipesBlautia +3 more PubMed ↗
Randomized trial The journal of nutrition, health & aging · 2025 Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial. Li M, Zhang Q, Zhao W, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Journal of dietary supplements · 2025 Efficacy of Probiotic Supplementation with Lactiplantibacillus plantarum Strains on Gastrointestinal Tract Function - A Randomized Controlled Trial. Singh RG, Aoki F, Rodriguez-Palmero Seuma M, et al. Lactiplantibacillus plantarum PubMed ↗
Randomized trial Nutrients · 2025 Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial. Laterza L, Cremon C, Coppola G, et al. Bifidobacterium animalisStreptococcus thermophilusLachnospira PubMed ↗
Randomized trial Molecular nutrition & food research · 2025 Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial. Ala-Jaakkola R, Forssten SD, Cheng J, et al. Bifidobacterium animalis PubMed ↗
Observational Gut microbes · 2025 Why do babies cry? Exploring the role of the gut microbiota in infantile colic, constipation, and cramps in the KOALA birth cohort study. Barnett D, Thijs C, Mommers M, et al. Mediterraneibacter gnavus PubMed ↗
Randomized trial Neurogastroenterology and motility · 2025 Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation. Roos S, Dahlgren AL, Mao YK, et al. Lactobacillus gasseri PubMed ↗
Randomized trial The Journal of nutrition · 2025 Effect of Daily Consumption of a Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota (LcS) on Stool Consistency in United States Adults with Hard or Lumpy Stools: A Randomized Controlled Trial. Cook CM, Akiyama T, Blonquist T, et al. Lacticaseibacillus paracasei PubMed ↗