Lacticaseibacillus paracasei
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Its ID gene: the stretch scientists read to tell microbes apart. Each bar is one letter of its DNA. Every species has its own order of letters, so the pattern works like a fingerprint. Close relatives share most of it.
16S rRNA gene, V4 region: the 253 letters between the standard primers (515F/806R), which are the same in every species. One reference sequence; strains can differ by a letter or two. NCBI NR_025880.1
Formerly Lactobacillus paracasei.
Mid-sized for a gut microbe: longer than 46% of the 2,354 we have genomes for.
46% G+C, higher than 46% of gut microbes.
To scale: if its ID gene were 1 cm long, its genome would stretch 20 meters. Yours would stretch 21 kilometers. One reference genome; strains vary. NCBI GCF_000155515.2
What it can do
- Can make lactic acid What yogurt bacteria make; other microbes turn it into butyrate.
- Can make B vitamins Folate, B12, riboflavin and others.
- Can ferment fiber Breaks down dietary fiber that our own enzymes can't.
- Can eat inulin A fiber in onions, garlic, leeks, chicory and bananas (also sold as FOS).
- Can use lactose The sugar in milk and dairy.
Not seen in its genomes: make butyrate, make propionate, eat resistant starch, eat pectin, feed on gut mucus, change bile acids, make hydrogen sulfide, make methane.
All 13 capabilities and their evidence
| Capability | Verdict | Genome analysis | Lab tests | Published research |
|---|---|---|---|---|
| Can make butyrate | Not seen | 0 of 14 genomes | — | No papers |
| Can make propionate | Not seen | 0 of 14 genomes | — | No papers |
| Can make lactic acid | Can | 14 of 14 genomes | — | No papers |
| Can ferment fiber | Can | 13 of 14 genomes | 36 of 57 strains · strip test | Papers say yes |
| Can eat inulin | Can | 13 of 14 genomes | 36 of 54 strains · strip test | Papers say yes |
| Can eat resistant starch | Not seen | 0 of 14 genomes | — | No papers |
| Can eat pectin | Not seen | 0 of 14 genomes | — | No papers |
| Can use lactose | Can | 0 of 14 genomes | 38 of 54 strains | Papers say yes |
| Can feed on gut mucus | Not seen | 0 of 14 genomes | — | No papers |
| Can change bile acids | Not seen | 0 of 14 genomes | — | No papers |
| Can make B vitamins | Can | 14 of 14 genomes | — | No papers |
| Can make hydrogen sulfide | Not seen | 0 of 14 genomes | — | No papers |
| Can make methane | Not seen | 0 of 14 genomes | — | No papers |
AGORA2 (Heinken et al. 2023) via VMH, CC BY 4.0 · BacDive (DSMZ), CC BY 4.0 · NJC19 (Lim et al., Scientific Data 2020), CC0
In healthy guts
Found in 4.6% of healthy people.
- largest Segatella copri 6.2%
- 2nd largest Phocaeicola vulgatus 5.0%
- 3rd largest Faecalibacterium prausnitzii 4.7%
- 4th largest Bacteroides uniformis 3.2%
- 5th largest Agathobacter rectalis 2.5%
- 6th largest Alistipes putredinis 2.3%
- 7th largest Bifidobacterium longum 2.1%
- 8th largest Ruminococcus bromii 1.8%
- top 15% Lacticaseibacillus paracasei 0.02%
- 2,169 other microbes, each a sliver 56.7%
- 15.6%
On average, 0.02% of the microbes in a healthy gut: larger than 85% of species’ slices.
Every group, drawn the same way. Only some samples record age or sex, so each group says how many people it comes from. Tap one to see it above.
In conditions
Compared with healthy people in the same studies, it’s less common in none and more common in none. Only studies that had both are counted.
A difference is an association: it doesn’t mean this microbe causes, prevents or treats any of these.
In studies of how people live
Higher in omnivores than vegans
Fackelmann 2025 · 21,561 people Landmark study
Higher in 5 of 5 cohorts
Higher in vegetarians than vegans
Fackelmann 2025 · 21,561 people Landmark study
Higher in 5 of 5 cohorts
“Higher” is the study’s measure: on average, a bigger share of gut bacteria across everyone in the group, carriers or not. It isn’t how many people carry it. An association the authors report, measured once per person. It doesn’t mean a diet changes this microbe, or that the microbe affects health.
Recent research
Strains studied
How much each strain has been studied in people, not whether it works. Many trials test a strain inside a blend, so those are counted apart, and reviews are summaries of trials, so they're never counted as more trials.
35 strains of L. paracasei are named on product labels. 0 have human trials; 35 have none found yet, including Lpc-37, which is in 262 products.
L. paracasei Lpc-37
In 262 products →No human trials found yet
L. paracasei UALpc-04
In 52 products →No human trials found yet
L. paracasei CUL-08
In 30 products →No human trials found yet
L. paracasei HA-196
In 20 products →No human trials found yet
L. paracasei DSM 13434
In 13 products →No human trials found yet
L. paracasei HA-108
In 12 products →No human trials found yet
L. paracasei VP-100
In 10 products →No human trials found yet
L. paracasei VP-33
In 10 products →No human trials found yet
L. paracasei SD5275
In 8 products →No human trials found yet
L. paracasei SD-5218
In 7 products →No human trials found yet
L. paracasei ATCC SD5275
In 4 products →No human trials found yet
L. paracasei 13434
In 3 products →No human trials found yet
L. paracasei 431
In 2 products →No human trials found yet
L. paracasei A234
In 2 products →No human trials found yet
L. paracasei CUL-8
In 2 products →No human trials found yet
L. paracasei DSM 24733
In 2 products →No human trials found yet
L. paracasei HA-274
In 2 products →No human trials found yet
L. paracasei IMC-502
In 2 products →No human trials found yet
L. paracasei NI327
In 2 products →No human trials found yet
L. paracasei ST-11
In 2 products →No human trials found yet
L. paracasei Vpro 224
In 2 products →No human trials found yet
L. paracasei 101
In 1 product →No human trials found yet
L. paracasei ATCC 393
In 1 product →No human trials found yet
L. paracasei DSM 16105
In 1 product →No human trials found yet
L. paracasei KB-9
In 1 product →No human trials found yet
L. paracasei L26
In 1 product →No human trials found yet
L. paracasei LN226
In 1 product →No human trials found yet
L. paracasei LPC-00
In 1 product →No human trials found yet
L. paracasei LPC-9
In 1 product →No human trials found yet
L. paracasei MAK92L81P
In 1 product →No human trials found yet
L. paracasei R0215
In 1 product →No human trials found yet
L. paracasei VK4
In 1 product →No human trials found yet
L. paracasei VP-51
In 1 product →No human trials found yet
L. paracasei VP-62
In 1 product →No human trials found yet
L. paracasei VP-75
In 1 product →No human trials found yet
L. paracasei Shirota
also YIT 9029 Not a supplement Sold in a fermented milk drinkNo human trials found yet
Human trials, meta-analyses and systematic reviews naming the strain · animal and lab studies not counted · Data sources