Randomized trial BMJ open · 2026 BLIS study: a feasibility randomised controlled trial assessing compliance, acceptability and colonisation with different dosing regimens of the probiotic supplement Streptococcus salivarius K12 (Bactoblis) in adults in England. Wilcox CR, Cleary DW, Augustine M, et al. Streptococcus salivarius PubMed ↗
Randomized trial European journal of pediatrics · 2026 Preventing otitis media and respiratory tract infections with the oral probiotic Streptococcus salivarius K12. Halley C, Honeywill C, Kang J, et al. Streptococcus salivarius PubMed ↗
Clinical trial Nutrients · 2026 Gut Microbiota Changes Following Aerobic Exercise in Malnourished Octogenarians: An Assessor-Blinded Intervention Study Stratified by Nutritional Status. Yang H, Li J, Ren S, et al. Faecalibacterium prausnitziiStreptococcus salivarius PubMed ↗
Observational Pancreatology · 2026 Analysis of gut microbiome dynamics in patients with type 1 autoimmune pancreatitis before and after glucocorticoid treatment. Zhang XD, Shen XN, Liu CX, et al. Dorea formicigeneransStreptococcus salivarius PubMed ↗
Observational Gut microbes · 2026 Strain-level translocation and enrichment dynamics of oral bacteria in the lower gastrointestinal tract of stunted children. Yersin S, Gody JC, Mazel F, et al. Streptococcus salivarius PubMed ↗
Observational BMC microbiology · 2026 Oral dryness related symptoms in radiation-treated head and neck cancer patients: a pilot study of oral microbiome composition and function. Mougeot JC, Beckman MF, Henry AA, et al. Haemophilus parainfluenzaeStreptococcus salivarius PubMed ↗
Review Ageing research reviews · 2026 Advocating gut-retina connection and microbiota mediated pathways in management of age-related macular degeneration: Preclinical to clinical perspective. Waghmare PV, Kolekar KA, Bashir B, et al. Bifidobacterium bifidumBifidobacterium breveBifidobacterium longumEnterococcus faecalis +3 more PubMed ↗
Randomized trial Frontiers in cellular and infection microbiology · 2026 Effect of probiotic lozenges on improvement in tympanometric classification within 12 weeks in children aged 3-6 years with adenoid hypertrophy and otitis media with effusion undergoing non-surgical management: a randomized controlled trial. Shi J, Liu Y, Chen X, et al. Streptococcus salivarius PubMed ↗
Randomized trial BMC infectious diseases · 2026 Effect of probiotic colonization on oral hygiene and ventilator-associated pneumonia in ICU patients: a triple-blind randomized controlled trial. Salehi A, Ebrahimzadeh F, Behzadfar A, et al. Streptococcus salivarius PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2026 Probiotic-Containing Nanofiber-Based Dental Floss Suppresses Subgingival Red Complex Periopathogens: A Randomized Double-Blind Crossover Trial. Hromcik F, Holochova P, Bohm J, et al. Ligilactobacillus salivariusStreptococcus salivarius PubMed ↗
Review International journal of molecular sciences · 2025 A New Perspective on Nasal Microbiota Dysbiosis-Mediated Allergic Rhinitis: From the Mechanism of Immune Microenvironment Remodeling to Microbiota-Targeted Therapeutic Strategies. Du L, Cheng X, Liu B, et al. Streptococcus salivarius PubMed ↗
Clinical trial Frontiers in nutrition · 2025 Study to evaluate the safety and tolerability of Streptococcus salivarius eK12, a genetically modified strain derived from the oral probiotic S. salivarius K12: Results from a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Di Pierro F, Bugti AA, Bano A, et al. Streptococcus salivarius PubMed ↗
Review Alzheimer's & dementia · 2025 Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential. Rozenblum G, Ait-Aissa K, Zahran G, et al. Streptococcus salivarius PubMed ↗
Review Discover oncology · 2025 Understanding the potential of probiotics in oral cancer prevention: a short review on microbial modulation. Rivera C Ligilactobacillus salivariusStreptococcus salivarius PubMed ↗
Review Archives of microbiology · 2025 The role of probiotics in controlling oral biofilm formation and mitigating oral squamous-cell carcinoma risk. Naz SS, Zafar S Bifidobacterium animalisStreptococcus salivarius PubMed ↗
Review Folia microbiologica · 2025 Microbiota-based therapies in oral health and disorders. Salah AN, Doghish YA, Abbass SO, et al. Streptococcus salivarius PubMed ↗
Randomized trial The journal of contemporary dental practice · 2025 Oral Probiotic Containing Streptococcus salivarius K12 and Lactobacillus brevis CD2 for Preventing Bacterial Pneumonia in Severe COVID-19: Randomized Clinical Trial. Lauxen JR, Callegari-Jacques SM, Mombelli AS, et al. Streptococcus salivarius PubMed ↗
Review Journal of applied biomaterials & functional materials · 2025 Probiotics for caries prevention: A narrative review. Nizami MZI, Chu S, Chu S, et al. Streptococcus salivarius PubMed ↗
Observational Journal of gastroenterology · 2025 Development of gastric mucosa-associated microbiota in autoimmune gastritis with neuroendocrine tumors. Otani K, Nakatsu G, Fujimoto K, et al. Haemophilus parainfluenzaeStreptococcus salivariusVeillonella atypica PubMed ↗
Randomized trial Beneficial microbes · 2025 The impact of Bifidobacterium longum CCFM1112 on chronic constipation: a randomised, double-blind, placebo-controlled study. Liu W, Wang J, Xue Y, et al. Bifidobacterium longumAnaerobutyricum halliiStreptococcus salivarius PubMed ↗
Review Journal of International Society of Preventive & Community Dentistry · 2025 Effectiveness of Probiotics in Managing Oral Halitosis: A Systematic Review of Randomized Controlled Trials. Passadakis G, Neophytou C, Davidopoulou S, et al. Streptococcus salivarius PubMed ↗
Randomized trial Saudi medical journal · 2025 Impact of Z-spring appliance and clear aligner therapy on oral microorganisms in children: A clinical trial. Kapicıi İ, Erken Güngör Ö, Yildirim K, et al. Streptococcus salivarius PubMed ↗
Review Molecular biology reports · 2025 Analyzing potential of next-generation probiotics in cancer management. Naz SS, Zafar S Akkermansia muciniphilaBacteroides fragilisBifidobacterium animalisBifidobacterium bifidum +4 more PubMed ↗
Observational Digestion · 2025 Association between Microbiome Dysbiosis and Postoperative Disorders before and after Gastrectomy. Tanaka T, Fujii T, Takahashi H, et al. Bacteroides uniformisEscherichia coliFaecalibacterium prausnitziiStreptococcus salivarius PubMed ↗
Review Microorganisms · 2025 Streptococcus salivarius and Ligilactobacillus salivarius: Paragons of Probiotic Potential and Reservoirs of Novel Antimicrobials. Williams MD, Smith L Ligilactobacillus salivariusStreptococcus salivarius PubMed ↗
Observational Archives of dermatological research · 2025 Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample mendelian randomization analysis. Yu C, Yan W, Shucheng H, et al. Streptococcus salivarius PubMed ↗
Review Cancer treatment reviews · 2025 Managing strategies of chemotherapy and radiotherapy-induced oral mucositis. Wu Y, Shi W, Li C, et al. Streptococcus salivarius PubMed ↗
Randomized trial Dental and medical problems · 2025 Effect of tablets containing a paraprobiotic strain and the cranberry extract on caries incidence in preschool children: A randomized controlled trial. Olczak-Kowalczyk D, Turska-Szybka A, Twetman S, et al. Ligilactobacillus salivariusStreptococcus salivarius PubMed ↗
Review Life · 2024 Streptococcus salivarius Role as a Probiotic in Children's Health and Disease Prophylaxis-A Systematic Review. Al-Akel FC, Chiperi LE, Eszter VK, et al. Streptococcus salivarius PubMed ↗
Systematic review International journal of molecular sciences · 2024 Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review. Jotic A, Savic Vujovic K, Cirkovic A, et al. Streptococcus salivarius PubMed ↗
Observational BMC microbiology · 2024 Does gut microbiota dysbiosis impact the metabolic alterations of hydrogen sulfide and lanthionine in patients with chronic kidney disease? Garcia-Martinez Y, Alexandrova E, Iebba V, et al. Alistipes indistinctusCoprococcus eutactusMediterraneibacter gnavusStreptococcus salivarius PubMed ↗
Observational Journal of advanced research · 2024 Roles of oral and gut microbiota in acute myocardial infarction. Li YL, Chen BY, Feng ZH, et al. Streptococcus parasanguinisStreptococcus salivarius PubMed ↗
Review Critical reviews in microbiology · 2024 Competitive dynamics and balance between Streptococcus mutans and commensal streptococci in oral microecology. Ye D, Liu Y, Li J, et al. Streptococcus salivarius PubMed ↗
Observational International journal of molecular sciences · 2024 Genetic Patterns of Oral Cavity Microbiome in Patients with Sickle Cell Disease. Al-Sarraj F, Albiheyri R, Qari M, et al. Streptococcus salivariusVeillonella dispar PubMed ↗
Randomized trial Journal of the International Society of Sports Nutrition · 2024 The effect of probiotics and casein supplementation on aerobic capacity parameters of male soccer players. Imanian B, Hemmatinafar M, Daryanoosh F, et al. Bifidobacterium breveBifidobacterium longumStreptococcus salivarius PubMed ↗
Observational Journal of ovarian research · 2024 Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance. Hu L, Hong G, Li J, et al. Streptococcus salivarius PubMed ↗
Review Journal of oral biosciences · 2024 Development and establishment of oral microbiota in early life. Kageyama S, Takeshita T Streptococcus salivarius PubMed ↗
Randomized trial Digestive diseases and sciences · 2024 Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms. El-Salhy M, Hatlebakk JG Streptococcus salivarius PubMed ↗
Randomized trial Journal of clinical oncology · 2024 Streptococcus salivarius K12 Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors: A Randomized Controlled Trial. Peng X, Li Z, Pei Y, et al. Streptococcus salivarius PubMed ↗
Observational Gut and liver · 2023 The Possible Preventative Role of Lactate- and Butyrate-Producing Bacteria in Colorectal Carcinogenesis. Song CH, Kim N, Nam RH, et al. Agathobaculum butyriciproducensAnaerobutyricum halliiAnaerostipes hadrusBifidobacterium adolescentis +3 more PubMed ↗