Limosilactobacillus fermentum
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Its ID gene: the stretch scientists read to tell microbes apart. Each bar is one letter of its DNA. Every species has its own order of letters, so the pattern works like a fingerprint. Close relatives share most of it.
16S rRNA gene, V4 region: the 253 letters between the standard primers (515F/806R), which are the same in every species. One reference sequence; strains can differ by a letter or two. NCBI NR_104927.1
Formerly Lactobacillus fermentum.
Among the smallest for a gut microbe: longer than 9% of the 2,354 we have genomes for.
52% G+C, higher than 59% of gut microbes.
To scale: if its ID gene were 1 cm long, its genome would stretch 13 meters. Yours would stretch 21 kilometers. One reference genome; strains vary. NCBI GCF_005341425.1
What it can do
- Can make lactic acid What yogurt bacteria make; other microbes turn it into butyrate.
- Can make B vitamins Folate, B12, riboflavin and others.
- Can ferment fiber Breaks down dietary fiber that our own enzymes can't.
- Can use lactose The sugar in milk and dairy.
Not seen in its genomes or lab tests: make butyrate, make propionate, eat inulin, eat resistant starch, eat pectin, feed on gut mucus, change bile acids, make hydrogen sulfide, make methane.
All 13 capabilities and their evidence
| Capability | Verdict | Genome analysis | Lab tests | Published research |
|---|---|---|---|---|
| Can make butyrate | Not seen | 0 of 5 genomes | — | No papers |
| Can make propionate | Not seen | 0 of 5 genomes | — | No papers |
| Can make lactic acid | Can | 5 of 5 genomes | — | No papers |
| Can ferment fiber | Can | 5 of 5 genomes | 16 of 36 strains · strip test Strip tests often miss fiber-eaters, so this doesn't override the genomes. | Papers say yes |
| Can eat inulin | Not seen | 0 of 5 genomes | 0 of 35 strains · strip test | No papers |
| Can eat resistant starch | Not seen | 0 of 5 genomes | — | No papers |
| Can eat pectin | Not seen | 0 of 5 genomes | — | No papers |
| Can use lactose | Can | 0 of 5 genomes | 18 of 24 strains | No papers |
| Can feed on gut mucus | Not seen | 0 of 5 genomes | — | No papers |
| Can change bile acids | Not seen | 0 of 5 genomes | — | No papers |
| Can make B vitamins | Can | 5 of 5 genomes | — | Papers say yes |
| Can make hydrogen sulfide | Not seen | 0 of 5 genomes | — | No papers |
| Can make methane | Not seen | 0 of 5 genomes | — | No papers |
AGORA2 (Heinken et al. 2023) via VMH, CC BY 4.0 · BacDive (DSMZ), CC BY 4.0 · NJC19 (Lim et al., Scientific Data 2020), CC0
In healthy guts
Found in 2.7% of healthy people.
- largest Segatella copri 6.2%
- 2nd largest Phocaeicola vulgatus 5.0%
- 3rd largest Faecalibacterium prausnitzii 4.7%
- 4th largest Bacteroides uniformis 3.2%
- 5th largest Agathobacter rectalis 2.5%
- 6th largest Alistipes putredinis 2.3%
- 7th largest Bifidobacterium longum 2.1%
- 8th largest Ruminococcus bromii 1.8%
- top 15% Limosilactobacillus fermentum 0.01%
- 2,169 other microbes, each a sliver 56.7%
- 15.6%
On average, 0.01% of the microbes in a healthy gut: larger than 85% of species’ slices.
Every group, drawn the same way. Only some samples record age or sex, so each group says how many people it comes from. Tap one to see it above.
In conditions
Compared with healthy people in the same studies, it’s less common in none and more common in 2 conditions. Only studies that had both are counted.
A difference is an association: it doesn’t mean this microbe causes, prevents or treats any of these.
Strongest first, then the biggest gap · Each figure is 10 peopleRecent research
Strains studied
How much each strain has been studied in people, not whether it works. Many trials test a strain inside a blend, so those are counted apart, and reviews are summaries of trials, so they're never counted as more trials.
18 strains of L. fermentum are named on product labels. 0 have human trials; 18 have none found yet, including SD-5847, which is in 18 products.
L. fermentum SD-5847
In 18 products →No human trials found yet
L. fermentum SBS-1
In 15 products →No human trials found yet
L. fermentum VP-48
In 11 products →No human trials found yet
L. fermentum VP-106
In 10 products →No human trials found yet
L. fermentum HA-179
In 9 products →No human trials found yet
L. fermentum CUL-67
In 5 products →No human trials found yet
L. fermentum SD-2468
In 4 products →No human trials found yet
L. fermentum CECT 5716
In 2 products →No human trials found yet
L. fermentum Lf-33
In 2 products →No human trials found yet
L. fermentum VPro14
In 2 products →No human trials found yet
L. fermentum LF-61
In 1 product →No human trials found yet
L. fermentum MAK20L13F
In 1 product →No human trials found yet
L. fermentum ME-3
In 1 product →No human trials found yet
L. fermentum NBRC 3070
In 1 product →No human trials found yet
L. fermentum NBRC 3071
In 1 product →No human trials found yet
L. fermentum UALf-32
In 1 product →No human trials found yet
L. fermentum VP-64
In 1 product →No human trials found yet
L. fermentum VP-72
In 1 product →No human trials found yet
Human trials, meta-analyses and systematic reviews naming the strain · animal and lab studies not counted · Data sources