Randomized trial Journal of gastroenterology and hepatology · 2026 Consolidation Therapy of Probiotics With Rifaximin Prevent Relapse in Rifaximin-Responsive Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Randomized Clinical Trial. Zhong J, Xu Z, Chen W, et al. Enterococcus faecium PubMed ↗
Randomized trial Nutrients · 2026 Heyndrickxia coagulans IDCC 1201 Alters Gut Microbiome and Metabolome in Patients with Functional Bowel Disorders. Jeon HJ, Moon JS, Jeong HM, et al. [Clostridium] leptumAgathobacter rectalisRuminococcus bromii PubMed ↗
Review Reviews on environmental health · 2026 Dietary patterns, gut microbiota, and gastrointestinal disorders: mechanistic insights into irritable bowel syndrome and inflammatory bowel disease. Khial Y, Lathief S, Aliwi L, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Observational Journal of pediatric gastroenterology and nutrition · 2026 Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls. Santucci NR, Dike CR, Hellmann J, et al. Mediterraneibacter gnavus PubMed ↗
Review International immunopharmacology · 2026 Probiotic therapeutics: A critical review of mechanisms, clinical efficacy, and the frontier of precision microbiome modulation. Ashaolu TJ, Suttikhana I Akkermansia muciniphila PubMed ↗
Randomized trial Journal of gastroenterology and hepatology · 2025 Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial. Ghoshal UC, Ramakrishna BS, Rathi PM, et al. Bifidobacterium animalis PubMed ↗
Review British journal of hospital medicine · 2025 The Role of Colonic Microbiota in Constipation Predominant Irritable Bowel Syndrome: A Literature Review. Roy YJ, Mirani Y, Raju J, et al. Escherichia coli PubMed ↗
Systematic review European journal of gastroenterology & hepatology · 2025 Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis. Rokkas T, Ekmektzoglou K, Tsanou E, et al. Bifidobacterium animalisBifidobacterium longum PubMed ↗
Randomized trial Journal of pediatric gastroenterology and nutrition · 2025 Calcium butyrate efficacy in pediatric irritable bowel syndrome: Randomized placebo-controlled multiomics-based clinical trial. Cristofori F, Calabrese FM, Iacobellis I, et al. Mediterraneibacter gnavus PubMed ↗
Randomized trial Phytomedicine · 2025 Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial. Zhai L, Zheng Y, Lo CW, et al. Agathobacter rectalis PubMed ↗
Observational Journal of molecular medicine · 2025 Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients. Matijašić M, Barešić A, Čipčić Paljetak H, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Nutrients · 2025 Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial. Laterza L, Cremon C, Coppola G, et al. Bifidobacterium animalisStreptococcus thermophilus PubMed ↗
Randomized trial Nutrients · 2024 Effect of Postbiotic Bifidobacterium longum CECT 7347 on Gastrointestinal Symptoms, Serum Biochemistry, and Intestinal Microbiota in Healthy Adults: A Randomised, Parallel, Double-Blind, Placebo-Controlled Pilot Study. Naghibi M, Pont-Beltran A, Lamelas A, et al. Bifidobacterium longum PubMed ↗
Randomized trial Scientific reports · 2024 Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Kwon H, Nam EH, Kim H, et al. Akkermansia muciniphilaBacteroides cellulosilyticus PubMed ↗
Randomized trial NPJ biofilms and microbiomes · 2024 Fecal microbiota transplantation influences microbiota without connection to symptom relief in irritable bowel syndrome patients. Hartikainen AK, Jalanka J, Lahtinen P, et al. Segatella copri PubMed ↗
Observational The American journal of gastroenterology · 2024 Fecal Proteolytic Bacteria and Staphylococcal Superantigens Are Associated With Abdominal Pain Severity in Irritable Bowel Syndrome. Quan R, Decraecker L, Appeltans I, et al. Alistipes putredinisFaecalibacterium prausnitziiParaprevotella clara PubMed ↗
Randomized trial Gut microbes · 2024 Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Martin FP, Cominetti O, Berger B, et al. Bifidobacterium longum PubMed ↗
Randomized trial European journal of nutrition · 2024 Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Gut microbes · 2024 A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Srivastava S, Basak U, Naghibi M, et al. Bifidobacterium longum PubMed ↗
Randomized trial Digestive diseases and sciences · 2024 Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms. El-Salhy M, Hatlebakk JG Streptococcus salivarius PubMed ↗
Review Endocrinologia, diabetes y nutricion · 2024 Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome. Ruiz-Sánchez C, Escudero-López B, Fernández-Pachón MS Bifidobacterium bifidum PubMed ↗
Review Nutrients · 2024 Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. Salvatore S, Carlino M, Sestito S, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Gut microbes · 2024 Collinsella aerofaciens as a predictive marker of response to probiotic treatment in non-constipated irritable bowel syndrome. Gargari G, Mantegazza G, Cremon C, et al. Collinsella aerofaciens PubMed ↗
Observational Wiadomosci lekarskie · 2024 Differentiated approach to management of patients with irritable bowel syndrome and ulcerative colitis in non-alcoholic fatty liver disease. Sirchak YS, Kornash VV, Dutko OO, et al. Escherichia coli PubMed ↗
Review Advances in experimental medicine and biology · 2024 Probiotics in Functional Gastrointestinal Disorders. Hojsak I Bifidobacterium animalis PubMed ↗
Observational Terapevticheskii arkhiv · 2023 [Long-term probiotic administration for irritable bowel syndrome: a legal need]. Solovyeva OI, Nekrasova AS, Topalova IG, et al. Bifidobacterium longum PubMed ↗
Observational Probiotics and antimicrobial proteins · 2023 An 8-Week Course of Bifidobacterium longum 35624® Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Lenoir M, Wienke J, Fardao-Beyler F, et al. Bifidobacterium longum PubMed ↗
Review Neurogastroenterology and motility · 2023 Intestinal bacteria associated with irritable bowel syndrome and chronic fatigue. El-Salhy M Bacteroides stercorisFaecalibacterium prausnitziiStreptococcus thermophilus PubMed ↗
Review Drugs · 2023 Antibiotics and Probiotics for Irritable Bowel Syndrome. Goodoory VC, Ford AC Bifidobacterium bifidum PubMed ↗
Review Diagnostic microbiology and infectious disease · 2023 Microbiota and parasite relationship. Beyhan YE, Yıldız MR Faecalibacterium prausnitzii PubMed ↗
Observational Journal of gastroenterology and hepatology · 2023 The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study. Khoo XH, Chong CW, Talha AM, et al. Bifidobacterium longum PubMed ↗
Meta-analysis The Cochrane database of systematic reviews · 2023 Probiotics for management of functional abdominal pain disorders in children. Wallace C, Gordon M, Sinopoulou V, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Digestive diseases · 2023 Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Bustos Fernández LM, Man F, Lasa JS Faecalibacterium prausnitzii PubMed ↗
Review Clinical nutrition · 2022 A diet high in FODMAPs as a novel dietary strategy in diabetes? Chu N, Chan JC, Chow E Akkermansia muciniphila PubMed ↗
Systematic review Nutrients · 2022 Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis. Ceccherini C, Daniotti S, Bearzi C, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Scandinavian journal of gastroenterology · 2022 The fecal microbiota transplantation response differs between patients with severe and moderate irritable bowel symptoms. El-Salhy M, Mazzawi T, Hausken T, et al. [Eubacterium] siraeumAgathobacter rectalis PubMed ↗
Randomized trial United European gastroenterology journal · 2022 A starch- and sucrose-reduced dietary intervention in irritable bowel syndrome patients produced a shift in gut microbiota composition along with changes in phylum, genus, and amplicon sequence variant abundances, without affecting the micro-RNA levels. Nilholm C, Manoharan L, Roth B, et al. Lachnospira eligens PubMed ↗
Observational World journal of gastroenterology · 2022 Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. Sabaté JM, Iglicki F Bifidobacterium longum PubMed ↗
Randomized trial Terapevticheskii arkhiv · 2022 [The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study]. Yakovenko EP, Strokova TV, Ivanov AN, et al. Bifidobacterium longumEnterococcus faecium PubMed ↗
Observational BMC microbiology · 2021 Involvement of mucosal flora and enterochromaffin cells of the caecum and descending colon in diarrhoea-predominant irritable bowel syndrome. Yang J, Wang P, Liu T, et al. [Ruminococcus] torques PubMed ↗
Randomized trial Nutrients · 2021 The Effects of Human Milk Oligosaccharides on Gut Microbiota, Metabolite Profiles and Host Mucosal Response in Patients with Irritable Bowel Syndrome. Iribarren C, Magnusson MK, Vigsnæs LK, et al. Bifidobacterium adolescentisBifidobacterium longum PubMed ↗
Review Minerva gastroenterology · 2021 Microbiota and the irritable bowel syndrome. Sabo CM, Dumitrascu DL Escherichia coli PubMed ↗
Randomized trial Clinical gastroenterology and hepatology · 2021 A Nonviable Probiotic in Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study. Mack I, Schwille-Kiuntke J, Mazurak N, et al. Enterococcus faecalis PubMed ↗
Observational Gastroenterology · 2021 Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Baumgartner M, Lang M, Holley H, et al. Mediterraneibacter gnavus PubMed ↗
Randomized trial Nutrients · 2021 The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study. Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, et al. Streptococcus thermophilus PubMed ↗
Review Clinical nutrition ESPEN · 2021 Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Di Pierro F, Pane M Bifidobacterium longum PubMed ↗
Experimental biology and medicine · 2026 Causal effects of gut microbiota on functional gastrointestinal disorders: a bidirectional Mendelian randomization study. Cheng Y, Shu Q, Wang Z, et al. Eubacterium ventriosum PubMed ↗
Journal of ethnopharmacology · 2026 Tong-Xie-Yao-Fang ameliorates IBS-D: Potential role of Alistipes finegoldii-associated gut tryptophan indole metabolism. Ying Y, Zheng X, Yang J, et al. Alistipes finegoldii PubMed ↗
BMC research notes · 2026 Widespread adhesion and iron acquisition traits in Escherichia coli strains obtained from irritable bowel syndrome (IBS) patients. Khadiv A, Yazdanmanesh M, Heidari H, et al. Escherichia coli PubMed ↗
Cell host & microbe · 2026 Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance. Xu S, Lyu J, Bao G, et al. Agathobacter rectalis PubMed ↗