Randomized trial Experimental and clinical psychopharmacology · 2026 Effects of Bifidobacterium longum 1714 on low mood and related symptoms: A randomized, double-blind, placebo-controlled trial. Seamans KM, Patterson E, Holz C, et al. Bifidobacterium longum PubMed ↗
Observational Phytomedicine · 2026 Zuojin Pill ameliorates depression with gastrointestinal dysfunction via Parabacteroides distasonis. Qiao D, Huang Y, Ge C, et al. Parabacteroides distasonis PubMed ↗
Randomized trial Scientific reports · 2026 A study on the efficacy and safety of fecal microbiota transplantation as an adjunctive therapy for treating depressive episodes. Wang L, Zhang S, Liu Y, et al. Agathobacter rectalis PubMed ↗
Observational Journal of Alzheimer's disease · 2026 Association of yoga with cognitive and gut microbiome changes in Alzheimer's disease: An exploratory case-control study. Tiwari P, Gupta A, Kaushik M, et al. Collinsella aerofaciensFaecalibacterium prausnitziiRoseburia intestinalis PubMed ↗
Randomized trial BMC complementary medicine and therapies · 2025 The effect of probiotics on anxiety, depression, nicotine dependence, and metabolic biomarkers in smokers: a randomized clinical trial. Sadeghi N, Shams S, Mirlohian RS, et al. Bifidobacterium animalisBifidobacterium bifidumBifidobacterium longum PubMed ↗
Systematic review European journal of gastroenterology & hepatology · 2025 Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis. Rokkas T, Ekmektzoglou K, Tsanou E, et al. Bifidobacterium animalisBifidobacterium longum PubMed ↗
Meta-analysis Nutritional neuroscience · 2025 An updated systematic review and appraisal of the pathophysiologic mechanisms of probiotics in alleviating depression. Sulaiman NNY, Mohamad Nizam NB, Mohd Noor NA, et al. Bifidobacterium breve PubMed ↗
Randomized trial Nutrition · 2025 Exploring neurotransmitter regulation following probiotic supplementation in adults with subthreshold depression: A secondary analysis of a randomized controlled trial. Dacaya P, Sarapis K, Hall R, et al. Bifidobacterium longum PubMed ↗
Systematic review Nutrients · 2025 Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review. Śliwka A, Polak-Berecka M, Zdybel K, et al. Akkermansia muciniphilaBifidobacterium breve PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2025 Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depression scores in overweight or obese adults: A randomized, double-blind, controlled clinical trial. Aalipanah E, Askarpour M, Eskandari MH, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Scientific reports · 2025 The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial. Fries LR, Boehme M, Lavalle L, et al. Bifidobacterium longum PubMed ↗
Meta-analysis Journal of affective disorders · 2025 Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota. Li X, Wang X, Zhu L, et al. Phocaeicola vulgatus PubMed ↗
Randomized trial Journal of health, population, and nutrition · 2025 The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind, placebo-controlled clinical trial. Noori M, Shateri Z, Babajafari S, et al. Bifidobacterium longum PubMed ↗
Observational Journal of affective disorders · 2025 A shotgun metagenomic study identified short-chain fatty acid-producing species and their functions in the gut microbiome of adults with depressive symptoms: Large-scale shotgun sequencing data of the gut microbiota using a cross-sectional design. Kim SY, Woo SY, Kim HL, et al. Faecalibacterium prausnitzii PubMed ↗
Meta-analysis Current neuropharmacology · 2025 The Impact of Akkermansia muciniphila on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis. Khalili L, Park G, Nagpal R, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Clinical nutrition · 2024 Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, et al. Bifidobacterium animalis PubMed ↗
Randomized trial The British journal of nutrition · 2024 Evaluation of a probiotic blend on psychosocial health and biomarkers of inflammatory, immune and stress response in adults with subthreshold depression: a double-blind, randomised, placebo-controlled trial. Moschonis G, Sarapis K, Resciniti S, et al. Bifidobacterium longum PubMed ↗
Observational Translational psychiatry · 2024 Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes. Malan-Müller S, Vidal R, O'Shea E, et al. Haemophilus parainfluenzae PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2024 Probiotics may be useful for drug-induced liver dysfunction in patients with depression - A secondary analysis of a randomized clinical trial. Gawlik-Kotelnicka O, Burzyński J, Rogalski J, et al. Bifidobacterium longum PubMed ↗
Review Aging and disease · 2024 Gut Microbiota and Its Metabolites: The Emerging Bridge Between Coronary Artery Disease and Anxiety and Depression? Chen H, Zhang L, Li Y, et al. Faecalibacterium prausnitzii PubMed ↗
Observational Journal of advanced research · 2024 Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults. Jiang X, Wang X, Zhang M, et al. Veillonella atypica PubMed ↗
Review International journal of molecular sciences · 2024 Human Gut Microbiota for Diagnosis and Treatment of Depression. Averina OV, Poluektova EU, Zorkina YA, et al. Faecalibacterium prausnitzii PubMed ↗
Randomized trial Gut microbes · 2024 Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Martin FP, Cominetti O, Berger B, et al. Bifidobacterium longum PubMed ↗
Randomized trial Nutrients · 2024 Metabolic Status Influences Probiotic Efficacy for Depression-PRO-DEMET Randomized Clinical Trial Results. Gawlik-Kotelnicka O, Margulska A, Płeska K, et al. Bifidobacterium longum PubMed ↗
Randomized trial Journal of biomolecular structure & dynamics · 2023 The pharmacological actions of Danzhi-xiaoyao-San on depression involve lysophosphatidic acid and microbiota-gut-brain axis: novel insights from a systems pharmacology analysis of a double-blind, randomized, placebo-controlled clinical trial. Zhu X, Wu S, Zhou Y, et al. Mediterraneibacter gnavus PubMed ↗
Randomized trial Nutrients · 2023 PRO-DEMET Randomized Controlled Trial on Probiotics in Depression-Pilot Study Results. Gawlik-Kotelnicka O, Margulska A, Skowrońska A, et al. Bifidobacterium longum PubMed ↗
Review Neuropharmacology · 2023 Bifidobacterium breve Bif11 supplementation improves depression-related neurobehavioural and neuroinflammatory changes in the mouse. Sushma G, Vaidya B, Sharma S, et al. Bifidobacterium breve PubMed ↗
Randomized trial Psychiatry research · 2022 Exercise effect on the gut microbiota in young adolescents with subthreshold depression: A randomized psychoeducation-controlled Trial. Wang R, Cai Y, Lu W, et al. Blautia obeum PubMed ↗
Randomized trial Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022 Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial. Ullah H, Di Minno A, Esposito C, et al. Bifidobacterium longum PubMed ↗
Randomized trial Brain, behavior, and immunity · 2021 Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Tian P, Chen Y, Zhu H, et al. Bifidobacterium breve PubMed ↗
Observational Journal of the College of Physicians and Surgeons--Pakistan · 2021 Correlation between Intestinal Flora and Serum Inflammatory Factors in Post-stroke Depression in Ischemic Stroke. Kang Y, Yang Y, Wang J, et al. Enterococcus faecalis PubMed ↗
Randomized trial Nutrients · 2021 Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial. Lee HJ, Hong JK, Kim JK, et al. Bifidobacterium adolescentis PubMed ↗
Gut microbes · 2026 Integrated metagenomic and metabolomic analysis identifies severity-specific inflammatory and metabolic signatures in post-stroke depression. Chen W, Pan Y, Chen M, et al. Evtepia gabavorous PubMed ↗
Phytomedicine · 2026 Huangjin Shuangshen Jiawei decoction alleviated coronary heart disease comorbid with depression partly through gut microbiota-mediated regulation of the SRSF1-p53-ASPP1 signaling axis. Jia R, Wang Y, Wang J, et al. Faecalibacterium prausnitzii PubMed ↗
Journal of agricultural and food chemistry · 2026 6'-Sialyllactose Combined with Bifidobacterium animalis subsp. lactis BB12 Relieves Constipation and Depression-like Behaviors Induced by Loperamide in Mice by Regulating the Gut-Brain Axis. Tian Z, Tan Z, Zhang X, et al. Bifidobacterium animalis PubMed ↗
Journal of applied microbiology · 2026 A probiotic BL53 enhances the immunomodulatory and neurorestorative activities of red ginseng in cyclophosphamide-exposed mice through the transformation of ginsenosides to compound K. Kim HI, Ma X, Kim SM, et al. Bifidobacterium animalisLactobacillus gasseri PubMed ↗
Journal of pharmaceutical and biomedical analysis · 2026 A distinct plasma lipidomic signature and multi-omics network in depression of polycystic ovary syndrome. Yan F, Sui M, Gao H, et al. Bacteroides eggerthii PubMed ↗
Pharmacological research · 2026 Gut microbiota drives dietary lignans to improve perimenopausal depression via activating hippocampal ERβ/GluN2A/PSD95 pathway. Yang C, Zhang X, Bie J, et al. Bacteroides ovatus PubMed ↗
Journal of neuroinflammation · 2026 Roseburia intestinalis ameliorates adolescent depression via GPR43‑dependent Treg cell expansion and suppression of neuroinflammation. Liu J, Fu L, Tang Z, et al. Roseburia intestinalis PubMed ↗
Brain, behavior, and immunity · 2026 The impact of adverse childhood experiences on gut microbiota and markers of inflammation is mediated by obesity and depression. Hantsoo L, Ford E, Friedman ES, et al. Bacteroides thetaiotaomicronBifidobacterium longum PubMed ↗