Randomized trial Experimental and clinical psychopharmacology · 2026 Effects of Bifidobacterium longum 1714 on low mood and related symptoms: A randomized, double-blind, placebo-controlled trial. Seamans KM, Patterson E, Holz C, et al. Bifidobacterium longum PubMed ↗
Observational Phytomedicine · 2026 Zuojin Pill ameliorates depression with gastrointestinal dysfunction via Parabacteroides distasonis. Qiao D, Huang Y, Ge C, et al. Parabacteroides distasonis PubMed ↗
Randomized trial Scientific reports · 2026 A study on the efficacy and safety of fecal microbiota transplantation as an adjunctive therapy for treating depressive episodes. Wang L, Zhang S, Liu Y, et al. Agathobacter rectalis PubMed ↗
Observational Journal of Alzheimer's disease · 2026 Association of yoga with cognitive and gut microbiome changes in Alzheimer's disease: An exploratory case-control study. Tiwari P, Gupta A, Kaushik M, et al. Collinsella aerofaciensFaecalibacterium prausnitziiRoseburia intestinalis PubMed ↗
Randomized trial BMC complementary medicine and therapies · 2025 The effect of probiotics on anxiety, depression, nicotine dependence, and metabolic biomarkers in smokers: a randomized clinical trial. Sadeghi N, Shams S, Mirlohian RS, et al. Bifidobacterium animalisBifidobacterium bifidumBifidobacterium longum PubMed ↗
Systematic review European journal of gastroenterology & hepatology · 2025 Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis. Rokkas T, Ekmektzoglou K, Tsanou E, et al. Bifidobacterium animalisBifidobacterium longum PubMed ↗
Meta-analysis Nutritional neuroscience · 2025 An updated systematic review and appraisal of the pathophysiologic mechanisms of probiotics in alleviating depression. Sulaiman NNY, Mohamad Nizam NB, Mohd Noor NA, et al. Bifidobacterium breve PubMed ↗
Randomized trial Nutrition · 2025 Exploring neurotransmitter regulation following probiotic supplementation in adults with subthreshold depression: A secondary analysis of a randomized controlled trial. Dacaya P, Sarapis K, Hall R, et al. Bifidobacterium longum PubMed ↗
Systematic review Nutrients · 2025 Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review. Śliwka A, Polak-Berecka M, Zdybel K, et al. Akkermansia muciniphilaBifidobacterium breve PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2025 Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depression scores in overweight or obese adults: A randomized, double-blind, controlled clinical trial. Aalipanah E, Askarpour M, Eskandari MH, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Scientific reports · 2025 The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial. Fries LR, Boehme M, Lavalle L, et al. Bifidobacterium longum PubMed ↗
Meta-analysis Journal of affective disorders · 2025 Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota. Li X, Wang X, Zhu L, et al. Phocaeicola vulgatus PubMed ↗
Randomized trial Journal of health, population, and nutrition · 2025 The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind, placebo-controlled clinical trial. Noori M, Shateri Z, Babajafari S, et al. Bifidobacterium longum PubMed ↗
Observational Journal of affective disorders · 2025 A shotgun metagenomic study identified short-chain fatty acid-producing species and their functions in the gut microbiome of adults with depressive symptoms: Large-scale shotgun sequencing data of the gut microbiota using a cross-sectional design. Kim SY, Woo SY, Kim HL, et al. Faecalibacterium prausnitzii PubMed ↗
Meta-analysis Current neuropharmacology · 2025 The Impact of Akkermansia muciniphila on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis. Khalili L, Park G, Nagpal R, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Clinical nutrition · 2024 Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, et al. Bifidobacterium animalis PubMed ↗
Randomized trial The British journal of nutrition · 2024 Evaluation of a probiotic blend on psychosocial health and biomarkers of inflammatory, immune and stress response in adults with subthreshold depression: a double-blind, randomised, placebo-controlled trial. Moschonis G, Sarapis K, Resciniti S, et al. Bifidobacterium longum PubMed ↗
Observational Translational psychiatry · 2024 Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes. Malan-Müller S, Vidal R, O'Shea E, et al. Haemophilus parainfluenzae PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2024 Probiotics may be useful for drug-induced liver dysfunction in patients with depression - A secondary analysis of a randomized clinical trial. Gawlik-Kotelnicka O, Burzyński J, Rogalski J, et al. Bifidobacterium longum PubMed ↗
Review Aging and disease · 2024 Gut Microbiota and Its Metabolites: The Emerging Bridge Between Coronary Artery Disease and Anxiety and Depression? Chen H, Zhang L, Li Y, et al. Faecalibacterium prausnitzii PubMed ↗