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ALS (amyotrophic lateral sclerosis)

Compared within 1 study that had both: 37 people with ALS (amyotrophic lateral sclerosis) and 29 healthy people. 2 microbes are less common in people with ALS (amyotrophic lateral sclerosis), and none more common.

A difference is an association: it doesn’t mean these microbes cause, prevent or treat ALS (amyotrophic lateral sclerosis).

Phylum

Searching opens both lists and shows only matching rows.

Less common in ALS (amyotrophic lateral sclerosis) · 2

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people
  1. Massilioclostridium coli in 1 study Healthy 45% ALS (amyotrophic lateral sclerosis) 11%
  2. Bifidobacterium pseudocatenulatum in 1 study Healthy 72% ALS (amyotrophic lateral sclerosis) 35%

More common in ALS (amyotrophic lateral sclerosis) · 0

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people

None compared.

Where these numbers come from

Studies
Only GMrepo projects that had people with the condition and healthy people, 10 or more of each. Numbers come from those studies, never from pooling.
How common
The share of people whose sample has any of it, in the people with the condition and in the healthy people of those same studies. Tested within studies (Cochran–Mantel–Haenszel, corrected for testing many microbes); a difference counts when it is clear and meaningful (Cohen’s h of 0.2 or more).
Strength word
Counted by code from how many studies point the same way: Seen again and again (3 or more, none clearly the other way), Seen more than once (2, the majority), Seen once (1, listed last). Where studies disagree, a row isn’t listed.
Each study
Tap a row for every study’s own numbers, and for how much carriers have.
Analysis
Our analysis of GMrepo data. GMrepo on Data sources · Read the rules

Also compared · 245 microbes

Compared within studies that had both, but not listed above.

No meaningful difference · 245
PubMed · human studies and reviews first

Recent research

All research on it
  1. Review International journal of molecular sciences · 2026
    Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.
    PubMed ↗
  2. Review Frontiers in immunology · 2026
    Targeting gut-brain-immune axis in amyotrophic lateral sclerosis.
    PubMed ↗
  3. Systematic review Molecular neurobiology · 2025
    Microbiota Dysbiosis in Amyotrophic Lateral Sclerosis: A Systematic Review of Human Studies.
    PubMed ↗
  4. Gut microbes · 2024
    Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice.
    PubMed ↗
  5. Gut microbes · 2024
    Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis.
    PubMed ↗

Source: PubMed, U.S. National Library of Medicine · 11 linked papers, last 10 years