Randomized trial Medicine · 2026 Healthy subjects gut microbiome modulation by Bacillus coagulans BCP92: A randomized, double-blind, placebo-controlled clinical trial. Shaikh SS, Malek F Heyndrickxia coagulans PubMed ↗
Randomized trial Nutrients · 2026 A Chewing Gum Containing Heyndrickxia coagulans SNZ1969® and Volatile Sulphur Compounds: An Exploratory Secondary Analysis of a Double-Blind Randomized Controlled Trial. Cirio S, Mantegazza G, Salerno C, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Nutrients · 2026 Heyndrickxia coagulans IDCC 1201 Alters Gut Microbiome and Metabolome in Patients with Functional Bowel Disorders. Jeon HJ, Moon JS, Jeong HM, et al. Heyndrickxia coagulans[Clostridium] leptumAgathobacter rectalisRuminococcus bromii +1 more PubMed ↗
Randomized trial Journal of the Indian Society of Pedodontics and Preventive Dentistry · 2026 Comparative effectiveness of biotic-based toothpastes in children with special health care needs: A randomized controlled trial. Kale YJ, Lingayat SD, Dadpe MV, et al. Heyndrickxia coagulansStreptococcus PubMed ↗
Randomized trial Biotechnology journal · 2026 Synbiotic Supplementation With Heyndrickxia coagulans TBC169 Improves Chronic Constipation in Middle-Aged and Elderly. Zhou X, Guo C, Hu G, et al. Heyndrickxia coagulansAkkermansiaBlautiaCollinsella +1 more PubMed ↗
Randomized trial Nutrients · 2026 Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study. Kim H, Lee J, Bang WY, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial PloS one · 2026 Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: A randomized, double-blind, placebo-controlled trial. Park HG, Lee HB, Lee M, et al. Bacillus subtilisClostridium butyricumHeyndrickxia coagulans PubMed ↗
Randomized trial European journal of nutrition · 2026 Weizmannia coagulans BC99 improved intestinal motility and chronic constipation through regulating gut microbiota: a randomized, double-blind, placebo-controlled trial. Wu Y, Zhou Y, Fan Q, et al. Heyndrickxia coagulansBifidobacteriumEscherichia PubMed ↗
Review Virology journal · 2026 Pharmacological and non-pharmacological management of long COVID. Khalid K, Abdullah ADI, Lim HX, et al. Bacillus subtilisHeyndrickxia coagulansLactobacillus acidophilus PubMed ↗
Randomized trial Nutrients · 2026 Assessing the Impact of Heyndrickxia coagulans Administered Through Sugar-Free Chewing Gum on Dental Biofilm: A Double-Blind Randomized Controlled Trial. Cirio S, Mantegazza G, Salerno C, et al. Heyndrickxia coagulans PubMed ↗
Review Nutrients · 2026 Neurocosmetics or Hype? Psychobiotic Potential of Strain-Specific Cosmeceuticals. Menni AE, Theodorou H, Tzikos G, et al. Heyndrickxia coagulansLactococcus lactisLimosilactobacillus reuteri PubMed ↗
Randomized trial Beneficial microbes · 2026 Effects of a Bacillus subtilis HU58 and Heyndrickxia faecalis SC208 spore-forming probiotic formula on gastrointestinal health: results of a randomised, double-blind, placebo-controlled pilot study. Sorensen K, Khanna S, Porwal A, et al. Bacillus subtilisHeyndrickxia coagulans PubMed ↗
Randomized trial Free radical biology & medicine · 2026 Weizmannia coagulans BC99 alleviates alcohol-induced oxidative stress and gut barrier dysfunction via modulation of butyrate metabolism: A randomized, double-blind, placebo-controlled trial. Wang Y, Guo J, Dong Y, et al. Heyndrickxia coagulans PubMed ↗
Review Journal of clinical medicine · 2026 Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Maslennikov R, Gosteeva E, Ananeva V, et al. Bifidobacterium longumHeyndrickxia coagulansLacticaseibacillus rhamnosusLactobacillus gasseri +1 more PubMed ↗
Review Cureus · 2026 Multispecies Probiotic Supplementation in Chronic Kidney Disease (CKD): Insights From Indian Nephrology Experts. Beniwal P, Singla M, Kar DP, et al. Bifidobacterium longumHeyndrickxia coagulansLactobacillus acidophilusStreptococcus thermophilus PubMed ↗
Review Frontiers in oral health · 2026 Oral health benefits of Heyndrickxia coagulans: a systematic review and meta-analysis of current evidence. Cirio S, Campus G, Salerno C, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Journal of the World federation of orthodontists · 2026 Antimicrobial effects of four different probiotic compositions and delivery forms on clear aligner biofilm: A randomized single-blind crossover trial. Thakur V, Juneja A, Raza M, et al. Heyndrickxia coagulansLacticaseibacillus paracasei PubMed ↗
Review Food & function · 2026 Heyndrickxia coagulans as a next-generation probiotic: current evidence and future perspectives. Ke S, Chen Z, Qi Y, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Medicine · 2025 Weizmannia coagulans BC01 supplementation improved functional constipation by regulating gut microbiota: A randomized, placebo-controlled, clinical study. Xu Y, Zhang Y, Yue F, et al. Heyndrickxia coagulansBacteroidesBifidobacteriumBlautia +1 more PubMed ↗
Review World journal of gastrointestinal pharmacology and therapeutics · 2025 Harnessing postbiotics for liver health: Emerging perspectives. Jeyaraman N, Jeyaraman M, Mariappan T, et al. Akkermansia muciniphilaHeyndrickxia coagulans PubMed ↗
Observational Italian journal of pediatrics · 2025 Efficacy of a mixture of simethicone and tyndallized bacillus coagulans in infant colic: a pilot study on behalf of Italian Society of Pediatrics (SIP). Saviano M, Russo M, Buono P, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial International immunopharmacology · 2025 Weizmannia coagulans BC99 alleviates pediatric allergic rhinitis via the gut microbiota-SCFAs- immunomodulatory axis: A randomized, double-blind, placebo-controlled trial. Han Z, Zhu H, Yang Y, et al. Heyndrickxia coagulansBifidobacteriumCollinsellaEscherichia +1 more PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2025 Multi-Strain Probiotics Alleviate Alcoholic Liver Disease Via Microbiota-Metabolism Axis: A Randomized Controlled Study. Feng J, Wu J, Zhang M, et al. Bifidobacterium animalisHeyndrickxia coagulansLacticaseibacillus rhamnosusAkkermansia +1 more PubMed ↗
Randomized trial Frontiers in immunology · 2025 Weizmannia coagulans BC99 regulates oxidative stress and serum metabolic pathways to improve allergic rhinitis: a randomized, double-blind, placebo-controlled trial. Li X, Han Z, Wu K, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Nutrients · 2025 The Impact of Weizmannia coagulans BC99 on Anxiety and Depression: An 8-Week Clinical Pilot Study Through the Gut Microbiota-Brain Axis. Tie S, Pan Y, Pang C, et al. Heyndrickxia coagulansAgathobacterDialister PubMed ↗
Randomized trial Frontiers in immunology · 2025 Integrated metabolomic insights into the mechanism of Bacillus coagulans in enhancing intestinal recovery following gynecological laparoscopic surgery: a randomized clinical trial. Xu J, Dong L, Feng C, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Beneficial microbes · 2025 Impact of Heyndrickxia (Bacillus) coagulans GBI-30, 6086 (BC30) probiotic on gastrointestinal function in healthy adults: a randomised controlled trial. Gang H, Wei J, McFarland LV, et al. Heyndrickxia coagulansBacteroidesBlautiaClostridium +1 more PubMed ↗
Randomized trial JPMA. The Journal of the Pakistan Medical Association · 2025 Application of novel nosocomial infection prevention and control combined with intestinal probiotics in children with hand, foot and mouth disease. Tao Y, Lu H, Huang J, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Beneficial microbes · 2025 Bacillus coagulans Unique IS2 improves stool characteristics in healthy adults with infrequent bowel movements: a randomized, double-blind, placebo-controlled trial. LeMoire A, Replogle R, Shinn L, et al. Heyndrickxia coagulans PubMed ↗
Review World journal of nephrology · 2025 Optimizing chronic kidney disease management: The potential of a multi-strain probiotic formulation. Chafekar D Bifidobacterium longumHeyndrickxia coagulansLactobacillus acidophilusStreptococcus thermophilus PubMed ↗
Randomized trial International journal of clinical pharmacy · 2025 Bacillus coagulans TBC169 probiotics for intestinal function recovery after gynecological open surgery: a randomized, double-blind, placebo-controlled trial. Guan Z, Zhang Z, Jia P, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Nutrients · 2025 The Improvement Effects of Weizmannia coagulans BC99 on Liver Function and Gut Microbiota of Long-Term Alcohol Drinkers: A Randomized Double-Blind Clinical Trial. Zhang J, Li C, Duan M, et al. Heyndrickxia coagulansEscherichiaFaecalibacteriumPrevotella +1 more PubMed ↗
Randomized trial Nutrients · 2024 Weizmannia coagulans BC99 Improves Strength Performance by Enhancing Protein Digestion and Regulating Skeletal Muscle Quality in College Students of Physical Education Major. Cao L, Guo M, Zhou Y, et al. Heyndrickxia coagulans PubMed ↗
Clinical trial Open forum infectious diseases · 2024 High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA). Hodzhev V, Dzhambazov K, Sapundziev N, et al. Heyndrickxia coagulansSaccharomyces cerevisiae PubMed ↗
Review Probiotics and antimicrobial proteins · 2024 Intestinal Dysbiosis: Exploring Definition, Associated Symptoms, and Perspectives for a Comprehensive Understanding - a Scoping Review. Carías Domínguez AM, de Jesús Rosa Salazar D, Stefanolo JP, et al. Heyndrickxia coagulansLacticaseibacillus rhamnosusLimosilactobacillus reuteriSaccharomyces cerevisiae PubMed ↗
Review Foods · 2024 The Potential of Bacillus Species as Probiotics in the Food Industry: A Review. Payne J, Bellmer D, Jadeja R, et al. Bacillus subtilisHeyndrickxia coagulans PubMed ↗
Randomized trial Medicine · 2024 Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial. Shaikh SS, Kumar S Heyndrickxia coagulans PubMed ↗
Randomized trial Nutrition · 2024 Improvement of skin condition and intestinal microbiota via Heyndrickxia coagulans SANK70258 intake: A placebo-controlled, randomized, double-blind, parallel-group comparative study. Togawa N, Yamada R, Aoki Y, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Frontiers in immunology · 2024 Heyndrickxia coagulans strain SANK70258 suppresses symptoms of upper respiratory tract infection via immune modulation: a randomized, double-blind, placebo-controlled, parallel-group, comparative study. Aida M, Togawa N, Mizuyama K, et al. Heyndrickxia coagulans PubMed ↗
Review Indian journal of microbiology · 2024 Therapeutic Role of Probiotics in Gut-Brain Axis Under Microgravity. Sil M, Mitra D, Mukherjee N, et al. Heyndrickxia coagulans PubMed ↗