Meta-analysis Nutrients · 2026 Efficacy and Safety of Lactobacillus reuteri DSM 17938 in Pediatric Functional Abdominal Pain Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Rodríguez-Brown F, Guerra Valencia J, Hernández-Vásquez A Limosilactobacillus reuteri PubMed ↗
Randomized trial Nutrients · 2026 Long-Term Efficacy of Limosilactobacillus reuteri DSM17938 in the Prevention of Functional Abdominal Pain Disorders. Indrio F, Di Mauro A, Perrone G, et al. Limosilactobacillus reuteri PubMed ↗
Randomized trial Beneficial microbes · 2026 Effects of a Bacillus subtilis HU58 and Heyndrickxia faecalis SC208 spore-forming probiotic formula on gastrointestinal health: results of a randomised, double-blind, placebo-controlled pilot study. Sorensen K, Khanna S, Porwal A, et al. Bacillus subtilisHeyndrickxia coagulans PubMed ↗
Randomized trial Journal of gastroenterology and hepatology · 2025 Effect of Probiotics on the Gut Microbiota After Colonoscopy: A Multicenter, Randomized, Placebo-Controlled Clinical Study. Wei H, Wang J, Xiao X, et al. Bacillus subtilisEnterococcus faeciumBacteroidesKlebsiella PubMed ↗
Randomized trial The American journal of gastroenterology · 2025 Efficacy and Safety of Gelatin Tannate and Tyndallized Acid Lactic Bacteria in Adults With Chronic Diarrhea and Altered Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled Study. Santos J, Iordache A, Manolache M Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Observational Nutrients · 2025 Management of Post-Colonoscopy Syndrome with a Nutraceutical Intervention Based on Hericium erinaceus: A Retrospective Two-Arm Multicentre Analysis. Tursi A, D'Avino A, Brandimarte G, et al. Bifidobacterium animalisLactobacillus acidophilusLactiplantibacillus PubMed ↗
Randomized trial Beneficial microbes · 2025 Effects of spore-forming probiotic Bacillus subtilis HU58™ in children with antibiotic-associated diarrhoea: a randomised, double-blind, placebo-controlled trial. Sorensen K, Jog P, Mankar S, et al. Bacillus subtilisSaccharomyces PubMed ↗
Randomized trial Phytomedicine · 2025 Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial. Zhai L, Zheng Y, Lo CW, et al. Agathobacter rectalis PubMed ↗
Randomized trial Beneficial microbes · 2024 Oral supplementation of heat-killed Enterococcus faecalis strain EC-12 relieves gastrointestinal discomfort and alters the gut microecology in academically stressed students. Li J, Terajima T, Liu H, et al. Enterococcus faecalis PubMed ↗
Observational World journal of gastroenterology · 2024 Correlation between the neuroendocrine axis, microbial species, inflammatory response, and gastrointestinal symptoms in irritable bowel syndrome. Zhang X, Jin WW, Wang HG Faecalibacterium PubMed ↗
Observational The American journal of gastroenterology · 2024 Fecal Proteolytic Bacteria and Staphylococcal Superantigens Are Associated With Abdominal Pain Severity in Irritable Bowel Syndrome. Quan R, Decraecker L, Appeltans I, et al. Alistipes putredinisFaecalibacterium prausnitziiParaprevotella claraStaphylococcus PubMed ↗
Observational Digestive and liver disease · 2024 Differences in clinical manifestations and the fecal microbiome between irritable bowel syndrome and small intestinal bacterial overgrowth. Lu S, Chen Y, Guo H, et al. EscherichiaLachnoclostridium PubMed ↗
Review Endocrinologia, diabetes y nutricion · 2024 Evaluation of the efficacy of probiotics as treatment in irritable bowel syndrome. Ruiz-Sánchez C, Escudero-López B, Fernández-Pachón MS Bifidobacterium bifidumLactobacillus PubMed ↗
Review Nutrients · 2024 Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. Salvatore S, Carlino M, Sestito S, et al. Bifidobacterium animalisLacticaseibacillus rhamnosusLimosilactobacillus reuteri PubMed ↗
Meta-analysis BMC infectious diseases · 2023 The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials. Liu LH, Han B, Tao J, et al. Saccharomyces cerevisiae PubMed ↗
Meta-analysis Beneficial microbes · 2023 Systematic review with meta-analysis: effects of probiotic fungi on irritable bowel syndrome. Qing Q, Chen Y, Zheng DK, et al. Saccharomyces PubMed ↗
Systematic review Nutrients · 2023 Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Xie P, Luo M, Deng X, et al. Heyndrickxia coagulansLactobacillus acidophilusSaccharomyces cerevisiae PubMed ↗
Meta-analysis Journal of medical microbiology · 2023 Efficacy of probiotics, prebiotics and synbiotics in irritable bowel syndrome: a systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials. Zhang WX, Shi LB, Zhou MS, et al. LactobacillusSaccharomyces PubMed ↗
Randomized trial Helicobacter · 2023 Probiotic containing Lactobacillus reuteri DSM 17648 as an adjunct treatment for Helicobacter pylori infection: A randomized, double-blind, placebo-controlled trial. Ismail NI, Nawawi KNM, Hsin DCC, et al. Limosilactobacillus reuteri PubMed ↗
Review Frontiers in cellular and infection microbiology · 2023 Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms. Peng Y, Ma Y, Luo Z, et al. Limosilactobacillus reuteri PubMed ↗
Meta-analysis Gastroenterology · 2023 Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis. Goodoory VC, Khasawneh M, Black CJ, et al. Lactiplantibacillus plantarumBacillusBifidobacteriumEscherichia +1 more PubMed ↗
Randomized trial World journal of gastroenterology · 2023 Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome. Martoni CJ, Srivastava S, Damholt A, et al. Lactiplantibacillus PubMed ↗
Observational BMC gastroenterology · 2023 Eubiotic effect of rifaximin is associated with decreasing abdominal pain in symptomatic uncomplicated diverticular disease: results from an observational cohort study. Ivashkin V, Shifrin O, Maslennikov R, et al. AllisonellaAnaerostipesDialister PubMed ↗
Meta-analysis The Cochrane database of systematic reviews · 2023 Probiotics for management of functional abdominal pain disorders in children. Wallace C, Gordon M, Sinopoulou V, et al. Bifidobacterium animalisLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Journal of paediatrics and child health · 2023 Randomised controlled trial of melatonin for paediatric functional abdominal pain disorders. Dipasquale V, Palermo L, Barbalace A, et al. Lacticaseibacillus rhamnosus PubMed ↗
Randomized trial The American journal of gastroenterology · 2022 The Short-Term Efficacy of Bifidobacterium Quadruple Viable Tablet in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: Potentially Mediated by Metabolism Rather Than Diversity Regulation. Bai T, Xu Z, Xia P, et al. BifidobacteriumBarnesiellaButyricimonasSutterella PubMed ↗
Randomized trial Paediatric drugs · 2022 Efficacy and Safety of the Adjuvant Use of Probiotic Bacillus clausii Strains in Pediatric Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Vázquez-Frias R, Consuelo-Sánchez A, Acosta-Rodríguez-Bueno CP, et al. Bacillus PubMed ↗
Meta-analysis Nutrients · 2022 Effectiveness and Safety of Probiotics for Patients with Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of 10 Randomized Controlled Trials. Shang X, E FF, Guo KL, et al. BifidobacteriumLactobacillus PubMed ↗
Randomized trial World journal of gastroenterology · 2022 Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation. Mourey F, Decherf A, Jeanne JF, et al. Saccharomyces cerevisiae PubMed ↗
Randomized trial Gut and liver · 2022 Efficacy of a Synbiotic Containing Lactobacillus paracasei DKGF1 and Opuntia humifusa in Elderly Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Oh JH, Jang YS, Kang D, et al. Lacticaseibacillus paracasei PubMed ↗
Meta-analysis Nutrition reviews · 2022 Effects of Bifidobacterium animalis subspecies lactis supplementation on gastrointestinal symptoms: systematic review with meta-analysis. Araújo MM, Vogado CO, Mendes MM, et al. Bifidobacterium animalis PubMed ↗
Randomized trial European journal of gastroenterology & hepatology · 2022 Randomized control trial on the efficacy of Limosilactobacillus reuteri ATCC PTA 4659 in reducing inflammatory markers in acute uncomplicated diverticulitis. Ojetti V, Saviano A, Brigida M, et al. Limosilactobacillus reuteri PubMed ↗
Review The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022 [Duodenal Microbiome and Its Clinical Implications in Functional Dyspepsia]. Kim SH Streptococcus PubMed ↗
Randomized trial JPMA. The Journal of the Pakistan Medical Association · 2022 Role of Lactobacillus plantarum 299v versus Placebo in symptomatic improvement of irritable bowel syndrome patients. Moeen-Ul-Haq, Babar AN, Hassan MK, et al. Lactiplantibacillus plantarum PubMed ↗
Randomized trial Revista espanola de enfermedades digestivas · 2022 Randomized, double-blind, placebo-controlled clinical trial on the usefulness of probiotic Lactobacillus reuteri in bismuth-containing quadruple eradication therapy for infection with Helicobacter pylori. Moreno Márquez C, Fernández Álvarez P, Valdés Delgado T, et al. Limosilactobacillus reuteri PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2021 Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study. Venkataraman R, Shenoy R, Ahire JJ, et al. Heyndrickxia coagulans PubMed ↗
Randomized trial Clinical gastroenterology and hepatology · 2021 A Nonviable Probiotic in Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study. Mack I, Schwille-Kiuntke J, Mazurak N, et al. Enterococcus faecalisEscherichia PubMed ↗
Randomized trial Alternative therapies in health and medicine · 2021 A Randomized, Double-blind, Placebo-controlled, Parallel Study Evaluating the Efficacy of Bacillus subtilis MB40 to Reduce Abdominal Discomfort, Gas, and Bloating. Penet C, Kramer R, Little R, et al. Bacillus subtilis PubMed ↗
Medicine · 2026 Fecal microbiota profiling in patients with irritable bowel syndrome and small intestinal bacterial overgrowth. Cui X, Wang H, Zhang H, et al. Fusobacterium PubMed ↗
Minerva gastroenterology · 2026 A multi-compound dietary supplement to improve the well-being of symptomatic uncomplicated diverticular disease. Bertani L, Chico L, Balestrini L, et al. Lacticaseibacillus rhamnosus PubMed ↗
Journal of gastrointestinal and liver diseases · 2025 Gut Microbiota Perturbation Are Linked to Endoscopic Severity of Diverticular Disease. Tursi A, Procaccianti G, Turroni S, et al. AllisonellaAlloprevotellaBlautiaDialister +2 more PubMed ↗
Beneficial microbes · 2025 A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of irritable bowel syndrome in adults. Drago L, Corleto VD, Ciprandi G, et al. Bifidobacterium animalisBifidobacterium breveLacticaseibacillus paracaseiLactiplantibacillus plantarum PubMed ↗
European journal of gastroenterology & hepatology · 2024 Gut microbiota in symptomatic uncomplicated diverticular disease stratifies by severity of abdominal pain. Tursi A, Turroni S, De Bastiani R, et al. AgathobacterAlistipesBlautiaButyricimonas +3 more PubMed ↗
Voprosy pitaniia · 2023 [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Drozdov VN, Shikh EV, Astapovskii AA, et al. Bifidobacterium animalisBifidobacterium bifidumBifidobacterium longumLacticaseibacillus rhamnosus +2 more PubMed ↗
Inflammatory bowel diseases · 2023 Patient-Reported Outcomes Correlate With Microbial Community Composition Independent of Mucosal Inflammation in Pediatric Inflammatory Bowel Disease. Hellmann J, Ta A, Ollberding NJ, et al. ClostridiumHaemophilusKlebsiella PubMed ↗
Scandinavian journal of gastroenterology · 2022 Baseline gut microbial profiles are associated with the efficacy of Bacillus subtilis and Enterococcus faecium in IBS-D. Hong G, Li Y, Yang M, et al. Bacillus subtilisEnterococcus faeciumLachnospira eligensMediterraneibacter gnavus +7 more PubMed ↗
Frontiers in cellular and infection microbiology · 2022 Clinical study on sequential treatment of severe diarrhea irritable bowel syndrome with precision probiotic strains transplantation capsules, fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules. Lv L, Ruan G, Ping Y, et al. Bacillus subtilisEnterococcus faecium PubMed ↗
American journal of physiology. Gastrointestinal and liver physiology · 2022 Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome. Choo C, Mahurkar-Joshi S, Dong TS, et al. Segatella copri PubMed ↗
Scientific reports · 2022 Genetic and phenotypic diversity of fecal Candida albicans strains in irritable bowel syndrome. van Thiel IAM, Stavrou AA, de Jong A, et al. Saccharomyces cerevisiae PubMed ↗
Clinical and translational science · 2022 Peppermint oil effects on the gut microbiome in children with functional abdominal pain. Thapa S, Luna RA, Chumpitazi BP, et al. Collinsella PubMed ↗