Observational Frontiers in endocrinology · 2026 Gut microbiota variation in admixed Hispanic populations with polyendocrine metabolic ovarian syndrome. Gonzalez-Rodriguez LA, Jimenez-Ortega KM, Vargas-Robles D, et al. Fusicatenibacter saccharivorans PubMed ↗
Observational BJOG · 2026 Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study. Jing M, Chen X, Jiang M, et al. Parabacteroides merdae PubMed ↗
Observational F&S science · 2026 Integrative machine learning models to unravel gut microbial dysbiosis and functional disruption in polycystic ovary syndrome. Kaliappa GD, Palanisamy H, Vidyalakshmi S Mediterraneibacter gnavusPhocaeicola vulgatusRoseburia hominisSegatella copri PubMed ↗
Review Current drug metabolism · 2026 Exploring Microbiome-based Therapy: Bacterial Flavonoid Synthesis as a Novel Approach to PCOS Treatment. Goyal N, Sharma S, Bhatia R, et al. Escherichia coli PubMed ↗
Meta-analysis Frontiers in cellular and infection microbiology · 2025 Effect of probiotic-derived metabolites on hormonal and metabolic profiles in women with polycystic ovary syndrome: a systematic review and meta-analysis. Maddirevula MK, Nelson VK, Soliman M, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Nutrition journal · 2025 Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome: a randomized clinical trial. Shirani M, Bagherniya M, Sadeghi O, et al. Bifidobacterium longum PubMed ↗
Observational BMC endocrine disorders · 2025 Gut microbiota dysbiosis and short-chain fatty acid depletion in phlegm-dampness polycystic ovary syndrome: a cross-sectional 16S rRNA sequencing analysis. Xia XY, Chen Y, Zhang XJ, et al. Alistipes shahiiBlautia wexlerae PubMed ↗
Review Frontiers in endocrinology · 2025 Exercise reshapes gut microbiota to ameliorate core symptoms in PCOS: molecular mechanisms and therapeutic implications. Li Q, Chen L, Wang R Akkermansia muciniphila PubMed ↗
Review Journal of reproductive immunology · 2025 Linking altered gut microbiome to polycystic ovarian syndrome through immune mediated pathway. Pathak VA, Kshirsagar SJ, Deokar GS Escherichia coli PubMed ↗
Randomized trial Frontiers in endocrinology · 2024 Acupuncture for hormonal readiness and gut microbiota in obese polycystic ovary syndrome: an open-label, randomized controlled trial. Wu T, Xu G, Hong X, et al. Lactococcus lactisRoseburia faecis PubMed ↗
Observational Nursing research · 2024 Association of Gut Microbiota With Fatigue in Black Women With Polycystic Ovary Syndrome. Slack JE, Kosyakova N, Pelkmans JL, et al. Blautia obeumRuminococcus bromii PubMed ↗
Observational Journal of ovarian research · 2024 Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance. Hu L, Hong G, Li J, et al. Streptococcus salivarius PubMed ↗
Meta-analysis Reproductive sciences · 2024 Gut Microbiome Composition in Polycystic Ovary Syndrome Adult Women: A Systematic Review and Meta-analysis of Observational Studies. Zhu Q, Zhang N Bacteroides fragilisMediterraneibacter gnavusParabacteroides distasonis PubMed ↗
Randomized trial European journal of nutrition · 2022 Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study. Kaur I, Suri V, Sachdeva N, et al. Bifidobacterium bifidum PubMed ↗
Randomized trial European review for medical and pharmacological sciences · 2022 A low glycemic index, energy-restricted diet but not Lactobacillus rhamnosus supplementation changes fecal short-chain fatty acid and serum lipid concentrations in women with overweight or obesity and polycystic ovary syndrome. Łagowska K, Drzymała-Czyż S Akkermansia muciniphilaBifidobacterium longumFaecalibacterium prausnitzii PubMed ↗
Observational Nutrition · 2022 β-glucuronidase activity is associated with carbohydrate metabolism but not with androgen status in overweight and obese women with polycystic ovary syndrome. Łagowska K, Malinowska AM, Kapczuk K, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Review International journal of molecular sciences · 2021 Microbiome and PCOS: State-of-Art and Future Aspects. Giampaolino P, Foreste V, Di Filippo C, et al. Phocaeicola vulgatus PubMed ↗
Systematic review Reproductive sciences · 2021 Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review. Guo J, Shao J, Yang Y, et al. Faecalibacterium prausnitzii PubMed ↗
Journal of ovarian research · 2026 Bridging gut microbiota and polycystic ovary syndrome: the mediating role of metabolites and immune pathways via Mendelian randomization and mediation analysis. Li Y, Zhang Y, Liu W, et al. Lachnospira eligens PubMed ↗
Journal of ovarian research · 2026 Quercetin ameliorates PCOS ovarian fibrosis by modulating short-chain fatty acid synthesis via increased akkermansia muciniphila abundance. He X, Yang P, Zhang S, et al. Akkermansia muciniphila PubMed ↗
Nature communications · 2026 Sialic acid exacerbates polycystic ovary syndrome in mice by modulating gut microbiota-mediated bile acid metabolism and FXR activation. Zhao C, Zhang Y, Chen K, et al. Ligilactobacillus salivarius PubMed ↗
Journal of pharmaceutical and biomedical analysis · 2026 A distinct plasma lipidomic signature and multi-omics network in depression of polycystic ovary syndrome. Yan F, Sui M, Gao H, et al. Bacteroides eggerthii PubMed ↗
Journal of ovarian research · 2026 Exploring gut microbiome alterations and hormonal imbalances in polycystic ovary syndrome: insights from a comparative study. Patel J, Chaudhary H, Parekh B, et al. Roseburia intestinalis PubMed ↗
Medicine · 2026 Gut microbiota, lipid metabolism, and PCOS: A Mendelian randomization and mediation analysis. Li W, Gan J, Jiao J, et al. Bifidobacterium longum PubMed ↗
Frontiers in cellular and infection microbiology · 2025 Fecal propionate is a signature of insulin resistance in polycystic ovary syndrome. Dong S, Yao X, Jiao J, et al. Segatella copri PubMed ↗
African journal of reproductive health · 2024 Causal association between gut microbiome and polycystic ovary syndrome: A bidirectional Mendelian randomization study. Xia D, Xu L, Cheng X, et al. Mediterraneibacter gnavus PubMed ↗
Current medical science · 2024 Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study. Zhang JX, Li QL, Wang XY, et al. Anaerobutyricum hallii PubMed ↗
Nature metabolism · 2024 The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. Yun C, Yan S, Liao B, et al. Phocaeicola vulgatus PubMed ↗
Molecular neurobiology · 2023 Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients. Yu L, Chen X, Bai X, et al. [Ruminococcus] torquesBacteroides eggerthiiCoprococcus comes PubMed ↗
Phytomedicine · 2023 The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome. Gao Y, Mo S, Cao H, et al. Bifidobacterium animalis PubMed ↗
Frontiers in endocrinology · 2023 Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study. Liang Y, Zeng W, Hou T, et al. [Ruminococcus] torques PubMed ↗
Frontiers in endocrinology · 2023 Effects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome. Su YN, Wang MJ, Yang JP, et al. Bacteroides fragilisPhocaeicola dorei PubMed ↗
Reproductive sciences · 2023 The Nutritional Intervention Improves the Metabolic Profile of Overweight and Obese PCOS Along with the Differences in Gut Microbiota. Fu L, Li Y, Bian Y, et al. Agathobacter rectalisFlavonifractor plautiiPhocaeicola vulgatus PubMed ↗
Frontiers in endocrinology · 2022 High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota. Wang X, Xu T, Liu R, et al. Phocaeicola vulgatus PubMed ↗
Frontiers in cellular and infection microbiology · 2021 16S rDNA Full-Length Assembly Sequencing Technology Analysis of Intestinal Microbiome in Polycystic Ovary Syndrome. Dong S, Jiao J, Jia S, et al. Bacteroides fragilisMediterraneibacter gnavus PubMed ↗
Journal of endocrinological investigation · 2021 Gut microbiota alterations reveal potential gut-brain axis changes in polycystic ovary syndrome. Liang Z, Di N, Li L, et al. Bacteroides fragilisParabacteroides distasonis PubMed ↗
Animal study Frontiers in endocrinology · 2025 Laurolitsine ameliorates insulin resistance, ovarian dysfunction and gut microbiota dysbiosis in DHEA plus HFD-induced PCOS mice. Zhang Y, Chen M, Zhou Z, et al. Akkermansia muciniphila PubMed ↗
Animal study Journal of ovarian research · 2025 A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model. Esfandiarinezhad F, Zhan X, Tan SL, et al. Akkermansia muciniphila PubMed ↗
Animal study mSphere · 2025 Modulatory impact of Bifidobacterium longum subsp. longum BL21 on the gut-brain-ovary axis in polycystic ovary syndrome: insights into metabolic regulation, inflammation mitigation, and neuroprotection. Dong Y, Yang S, Zhang S, et al. Bifidobacterium longum PubMed ↗
Animal study Frontiers in immunology · 2023 E. coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22 via gut microbiota and microbial metabolism. Luo M, Chen Y, Pan X, et al. Escherichia coli PubMed ↗