Lactobacillus crispatus
What's this?
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Its ID gene: the stretch scientists read to tell microbes apart. Each bar is one letter of its DNA. Every species has its own order of letters, so the pattern works like a fingerprint. Close relatives share most of it.
16S rRNA gene, V4 region: the 253 letters between the standard primers (515F/806R), which are the same in every species. One reference sequence; strains can differ by a letter or two. NCBI NR_119274.1
Formerly Eubacterium crispatum.
Small for a gut microbe: longer than 13% of the 2,354 we have genomes for.
37% G+C, higher than 17% of gut microbes.
To scale: if its ID gene were 1 cm long, its genome would stretch 14 meters. Yours would stretch 21 kilometers. One reference genome; strains vary. NCBI GCF_009769205.1
What it can do
- Can make lactic acid What yogurt bacteria make; other microbes turn it into butyrate.
- Can ferment fiber Breaks down dietary fiber that our own enzymes can't.
- Can use lactose The sugar in milk and dairy.
- Can change bile acids Modifies the bile acids the liver makes to digest fat. 1 of 9 strains can
Not seen in its genomes or lab tests: make butyrate, make propionate, eat inulin, eat resistant starch, eat pectin, feed on gut mucus, make B vitamins, make hydrogen sulfide, make methane.
All 13 capabilities and their evidence
| Capability | Verdict | Genome analysis | Lab tests | Published research |
|---|---|---|---|---|
| Can make butyrate | Not seen | 0 of 9 genomes | — | No papers |
| Can make propionate | Not seen | 0 of 9 genomes | — | No papers |
| Can make lactic acid | Can | 9 of 9 genomes | — | No papers |
| Can ferment fiber | Can | 0 of 9 genomes | 10 of 19 strains · strip test | No papers |
| Can eat inulin | Not seen | 0 of 9 genomes | 0 of 17 strains · strip test | No papers |
| Can eat resistant starch | Not seen | 0 of 9 genomes | — | No papers |
| Can eat pectin | Not seen | 0 of 9 genomes | — | No papers |
| Can use lactose | Can | 9 of 9 genomes | 14 of 17 strains | Papers say yes |
| Can feed on gut mucus | Not seen | 0 of 9 genomes | — | No papers |
| Can change bile acids | Some strains | 1 of 9 genomes | — | No papers |
| Can make B vitamins | Not seen | 0 of 9 genomes | — | No papers |
| Can make hydrogen sulfide | Not seen | 0 of 9 genomes | — | No papers |
| Can make methane | Not seen | 0 of 9 genomes | — | No papers |
AGORA2 (Heinken et al. 2023) via VMH, CC BY 4.0 · BacDive (DSMZ), CC BY 4.0 · NJC19 (Lim et al., Scientific Data 2020), CC0
In healthy guts
Found in 1.6% of healthy people.
- largest Segatella copri 6.2%
- 2nd largest Phocaeicola vulgatus 5.0%
- 3rd largest Faecalibacterium prausnitzii 4.7%
- 4th largest Bacteroides uniformis 3.2%
- 5th largest Agathobacter rectalis 2.5%
- 6th largest Alistipes putredinis 2.3%
- 7th largest Bifidobacterium longum 2.1%
- 8th largest Ruminococcus bromii 1.8%
- Lactobacillus crispatus under 0.01%
- 2,169 other microbes, each a sliver 56.7%
- 15.6%
On average, a sliver, under 0.01% of the microbes in a healthy gut.
Every group, drawn the same way. Only some samples record age or sex, so each group says how many people it comes from. Tap one to see it above.
In conditions
Compared with healthy people in the same studies, it’s less common in none and more common in none. Only studies that had both are counted.
A difference is an association: it doesn’t mean this microbe causes, prevents or treats any of these.
Recent research
Strains studied
How much each strain has been studied in people, not whether it works. Many trials test a strain inside a blend, so those are counted apart, and reviews are summaries of trials, so they're never counted as more trials.
7 strains of L. crispatus are named on product labels. 0 have human trials; 7 have none found yet, including LBV 88, which is in 6 products.
L. crispatus LBV 88
In 6 products →No human trials found yet
L. crispatus UALcr-35
In 6 products →No human trials found yet
L. crispatus LMG P-31003
In 2 products →No human trials found yet
L. crispatus VP-60
In 2 products →No human trials found yet
L. crispatus CCFM1110
In 1 product →No human trials found yet
L. crispatus LCR01
In 1 product →No human trials found yet
L. crispatus LCr86
In 1 product →No human trials found yet
Human trials, meta-analyses and systematic reviews naming the strain · animal and lab studies not counted · Data sources