Review International journal of molecular sciences · 2026 Microbiome-Immune Interactions as Determinants of Checkpoint Inhibitor Efficacy in Hepatocellular Carcinoma. Ostafe MR, Volovat SR, Clement A, et al. Akkermansia muciniphila PubMed ↗
Review Frontiers in cellular and infection microbiology · 2026 From dysbiosis to malignancy: decoding gut-driven pathways to clinical management in hepatocellular carcinoma. Ismaiel A, Almonajjed MB, Wardeh M, et al. Akkermansia muciniphila PubMed ↗
Observational Digestive and liver disease · 2026 Genetically predicted gut bacteria, circulating bacteria-associated metabolites and liver cancer: A Mendelian randomisation study. Daniel N, Papadimitriou N, Chatziioannou AC, et al. Agathobacter rectalis PubMed ↗
Review Cancer biology & medicine · 2026 How the gut microbiome affects the immunotherapy response in hepatocellular carcinoma. Wu M, Zhang Y, Yu J Akkermansia muciniphilaKlebsiella pneumoniae PubMed ↗
Observational Journal of gastroenterology and hepatology · 2026 Gut Microbiome Signatures Differ in Cirrhosis With and Without Hepatocellular Carcinoma in a Southeast Asian Cohort. Jinato T, Sikaroodia M, Gilleveta PM, et al. Mediterraneibacter gnavus PubMed ↗
Observational Clinical and translational gastroenterology · 2025 Fecal Microbiota and Bile Acid Profiles in Early-Stage Hepatocellular Carcinoma: A Matched Case-Control Study. Nobel YR, Park H, Tillman AM, et al. Klebsiella pneumoniae PubMed ↗
Review International journal of surgery · 2025 Gut microbiota-mediated oncogenesis in hepatocellular carcinoma: a new avenue for therapeutic intervention. Ramesh A, Subbarayan R, Srinivasan D, et al. Enterococcus faecalisEscherichia coli PubMed ↗
Review Current oncology · 2025 Akkermansia muciniphila and HCC: A Gut Feeling. Capasso M, Sanduzzi-Zamparelli M, Cossiga V, et al. Akkermansia muciniphila PubMed ↗
Review Toxins · 2025 Comprehensive Review of Dietary Probiotics in Reducing Aflatoxin B1 Toxicity. Choi D, Fan X, Yu JH Lactococcus lactis PubMed ↗
Observational Cell reports. Medicine · 2025 Phocaeicola vulgatus induces immunotherapy resistance in hepatocellular carcinoma via reducing indoleacetic acid production. Zhao CN, Li SS, Yau T, et al. Phocaeicola vulgatus PubMed ↗
Review Frontiers in immunology · 2025 Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma. Yang Y, Shi X Akkermansia muciniphila PubMed ↗
Review Biomolecules · 2021 Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives. Vallianou N, Christodoulatos GS, Karampela I, et al. Akkermansia muciniphilaFaecalibacterium prausnitziiSegatella copri PubMed ↗
Observational Nature reviews. Gastroenterology & hepatology · 2021 E. faecalis promotes liver carcinogenesis. Ray K Enterococcus faecalis PubMed ↗
Journal of extracellular vesicles · 2026 Enterococcus faecalis Extracellular Vesicles Deliver the Bacterial GTPase Obg to Hijack mTOR Signalling in Hepatocellular Carcinoma. Ma N, Xie X, Wang J, et al. Enterococcus faecalis PubMed ↗
Frontiers in immunology · 2026 Stress accelerates hepatocellular carcinoma progression via a gut microbial-metabolite axis. Hu Z, Yue P, Yuan M, et al. Phocaeicola vulgatus PubMed ↗
Journal of extracellular vesicles · 2026 Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut-Liver Bacterial Translocation and Pro-Tumorigenic Processes. Tsubaki S, Nashimoto S, Tanaka R, et al. Klebsiella pneumoniae PubMed ↗
Cellular signalling · 2026 Functional and metabolic dysbiosis of the gut microbiome in the tumoral immune microenvironment of hepatocellular carcinoma. He Q, Wu H, Guo M, et al. Streptococcus salivarius PubMed ↗
Cell host & microbe · 2026 Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells. Ren X, Zheng G, Liu Y, et al. Enterocloster bolteae PubMed ↗
Journal for immunotherapy of cancer · 2026 Modulating Bacteroides to boost anti-PD-1 immunotherapy in HCC. Qi X, Yang M, Liu X, et al. Bacteroides thetaiotaomicron PubMed ↗
NPJ biofilms and microbiomes · 2025 Deconjugating taurocholic acid with Bifidobacterium to mitigate obesity-driven cancer progression by restoring CD8+ T-cell infiltration. Yuan R, Li Y, Wang Y, et al. Bifidobacterium breve PubMed ↗
Cancer discovery · 2025 Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations. Lu Y, Xu L, Chen W, et al. Enterococcus faecalis PubMed ↗
Hepatology · 2025 Distinct gut microbiota but common metabolomic signatures between viral and MASLD HCC contribute to outcomes of combination immunotherapy. Lee PC, Wu CJ, Hung YW, et al. Bacteroides ovatusEnterococcus faeciumMediterraneibacter gnavus PubMed ↗
Gut microbes · 2025 Dysregulation of gut microbiota stimulates NETs-driven HCC intrahepatic metastasis: therapeutic implications of healthy faecal microbiota transplantation. Deng Z, Mei S, Ouyang Z, et al. Anaerotruncus colihominisDysosmobacter welbionis PubMed ↗
Frontiers in immunology · 2025 Community characteristics and relationship between gut microbiota and intratumoral microbiota in hepatocellular carcinoma. Lin H, Ma Z, Li J, et al. Bacteroides stercorisFaecalibacterium prausnitzii PubMed ↗
Cell reports. Medicine · 2025 Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma. Wu XQ, Ying F, Chung KPS, et al. Akkermansia muciniphila PubMed ↗
Nature microbiology · 2025 Gut-liver translocation of pathogen Klebsiella pneumoniae promotes hepatocellular carcinoma in mice. Wang X, Fang Y, Liang W, et al. Klebsiella pneumoniae PubMed ↗
Gut microbes · 2024 Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib. Yu H, Lin G, Jiang J, et al. Enterococcus faecium PubMed ↗
Journal of medical microbiology · 2024 Altered intestinal Streptococcus anginosus and 5α-reductase gene levels in patients with hepatocellular carcinoma and elevated Bacteroides stercoris in atezolizumab/bevacizumab non-responders. Fujii T, Kuzuya T, Kondo N, et al. Bacteroides stercoris PubMed ↗
Toxicon · 2024 Antimutagenic activity of different forms of Bifidobacterium lactis probiotic against aflatoxin B1 by Ames method. Pakizeh M, Nouri L, Azizi MH Bifidobacterium animalis PubMed ↗
Applied microbiology and biotechnology · 2024 Distinct alterations of gut microbiota between viral- and non-viral-related hepatocellular carcinoma. Jinato T, Anuntakarun S, Satthawiwat N, et al. Mediterraneibacter gnavus PubMed ↗
Cell host & microbe · 2023 Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma. Yu J, Zhu P, Shi L, et al. Bifidobacterium longum PubMed ↗
Cancer science · 2023 Gut microbiome as a biomarker for predicting early recurrence of HBV-related hepatocellular carcinoma. Zheng C, Lu F, Chen B, et al. Bifidobacterium adolescentis PubMed ↗
Scientific reports · 2023 Gut dysbiosis in Thai intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Pomyen Y, Chaisaingmongkol J, Rabibhadana S, et al. Mediterraneibacter gnavus PubMed ↗
Scientific reports · 2023 Characteristics of gut microbiota in patients with metabolic associated fatty liver disease. Yang C, Xu J, Xu X, et al. Blautia obeum PubMed ↗
Journal of medical microbiology · 2023 Correlation analysis for alterations of intestinal flora in hepatocellular carcinoma patients: combinatorial detection of Coriobacterium, Atopobium, Coprococcus and Veillonella dispar may be a new method for HCC diagnosis. Xu W, Jiang Y, Tao J, et al. Veillonella dispar PubMed ↗
Frontiers in cellular and infection microbiology · 2023 Integrated microbiome and metabolome analysis reveals the interaction between intestinal flora and serum metabolites as potential biomarkers in hepatocellular carcinoma patients. Li X, Yi Y, Wu T, et al. Odoribacter splanchnicus PubMed ↗
Journal of cancer research and clinical oncology · 2022 Bacterial metabolite butyrate in modulating sorafenib-targeted microRNAs to curtail its resistance in hepatocellular carcinoma. Kumar M, Kaur R, Kanthaje S, et al. Faecalibacterium prausnitziiRoseburia intestinalis PubMed ↗
Hepatology · 2021 Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease. Kwan SY, Jiao J, Joon A, et al. Bacteroides caccaeParabacteroides distasonisSegatella copri PubMed ↗
World journal of gastroenterology · 2021 Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients. Chung MW, Kim MJ, Won EJ, et al. Enterococcus faeciumVeillonella atypica PubMed ↗
Scientific reports · 2021 Profiling of tumour-associated microbiota in human hepatocellular carcinoma. Komiyama S, Yamada T, Takemura N, et al. Mediterraneibacter gnavus PubMed ↗
Animal study Frontiers in bioscience · 2024 Bifidobacterium longum-Derived Extracellular Vesicles Prevent Hepatocellular Carcinoma by Modulating the TGF-β1/Smad Signaling in Mice. Li B, Chi X, Huang Y, et al. Bifidobacterium longum PubMed ↗
Animal study Journal for immunotherapy of cancer · 2023 2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis. Pan B, Chen Z, Zhang X, et al. Odoribacter splanchnicus PubMed ↗
Animal study Frontiers in immunology · 2022 Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6+ natural killer T cells. Li T, Lin X, Shen B, et al. Akkermansia muciniphila PubMed ↗
Animal study Nature communications · 2022 Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment. Schneider KM, Mohs A, Gui W, et al. Akkermansia muciniphila PubMed ↗