Randomized trial Food & function · 2026 Efficacy of Bifidobacterium animalis subsp. lactate BL-99 in relieving functional constipation: a randomized placebo-controlled clinical trial. Shao J, Hung W, Yin P, et al. Bifidobacterium animalisFaecalibacterium PubMed ↗
Randomized trial Journal of diabetes investigation · 2026 Effects of age, sex, and renal function on bowel movement-improving effects of Bifidobacterium bifidum G9-1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study. Ikeda F, Sato J, Yoshii H, et al. Bifidobacterium bifidum PubMed ↗
Randomized trial European journal of nutrition · 2026 The effectiveness of a plant-based milk with fermented brown rice on constipation symptoms via gut microbiota modulation: a double-blind randomized controlled trial. Tang A, Cao Q, Wang M, et al. Blautia PubMed ↗
Randomized trial Nutrients · 2026 A Heat-Inactivated Two-Strain Lacticaseibacillus paracasei Fermented Milk as a Postbiotic for Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial. Li X, Lan H, Guan Y, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Clinical nutrition · 2026 Effects of early postoperative synbiotic supplementation on gastrointestinal outcomes after sleeve gastrectomy: A randomized controlled trial. Altunsaray A, Dağ B, Dağ A Lacticaseibacillus rhamnosus PubMed ↗
Observational Nutrition · 2026 Associations of dietary diversity with constipation symptoms and gut microbiota features in individuals with functional constipation. Tang A, Tian T, Li W, et al. [Ruminococcus] torques PubMed ↗
Randomized trial Biotechnology journal · 2026 Synbiotic Supplementation With Heyndrickxia coagulans TBC169 Improves Chronic Constipation in Middle-Aged and Elderly. Zhou X, Guo C, Hu G, et al. Heyndrickxia coagulansBlautiaFaecalibacterium PubMed ↗
Randomized trial Biotechnology journal · 2026 Lactiplantibacillus plantarum Z6 Improves Functional Constipation in Infants. Zhou X, Hu G, Wu J, et al. Lactiplantibacillus plantarum PubMed ↗
Randomized trial PloS one · 2026 Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: A randomized, double-blind, placebo-controlled trial. Park HG, Lee HB, Lee M, et al. Bacillus subtilisClostridium butyricumHeyndrickxia coagulans PubMed ↗
Randomized trial Diabetes, obesity & metabolism · 2026 Bifidobacterium bifidum G9-1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open-Label, Randomized Controlled Trial (Binary STAR Study). Kobayashi G, Hashimoto Y, Matsuyama T, et al. Bifidobacterium bifidum PubMed ↗
Randomized trial Journal of ethnopharmacology · 2026 The adjunct use of Bifidobacterium animalis subsp. lactis BAMA-B06/BAu-B0111 improves the therapeutic efficacy of Liuwei'anxiao Capsule in alleviating constipation in Parkinson's Disease: A randomized controlled study. Lin M, Li S, Lin J, et al. Bifidobacterium animalis PubMed ↗
Randomized trial European journal of nutrition · 2026 Weizmannia coagulans BC99 improved intestinal motility and chronic constipation through regulating gut microbiota: a randomized, double-blind, placebo-controlled trial. Wu Y, Zhou Y, Fan Q, et al. Heyndrickxia coagulans PubMed ↗
Clinical trial Minerva gastroenterology · 2026 Efficacy of a probiotic-prebiotic mix on chronic constipation symptoms in the elderly: results of a pilot study. Montarsolo P, Barbagallo S, Fioravanti P, et al. Bifidobacterium animalisBifidobacterium breveLacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Clinical nutrition · 2026 A multi-strain probiotic formulation alleviates chronic constipation in middle-aged and older adults: A randomized, double-blind, placebo-controlled trial. Xiao R, He Y, Mao X, et al. Faecalibacterium PubMed ↗
Clinical trial Journal of diabetes investigation · 2026 Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study). Ikeda F, Sato J, Yoshii H, et al. Bifidobacterium bifidum PubMed ↗
Randomized trial Medicine · 2025 Weizmannia coagulans BC01 supplementation improved functional constipation by regulating gut microbiota: A randomized, placebo-controlled, clinical study. Xu Y, Zhang Y, Yue F, et al. Heyndrickxia coagulansBacteroidesBlautia PubMed ↗
Review Current opinion in clinical nutrition and metabolic care · 2025 An update on probiotics in paediatrics. Zemła M, Kotowska-Bąbol M, Szajewska H Bifidobacterium animalisLacticaseibacillus rhamnosusLimosilactobacillus reuteriSaccharomyces cerevisiae +1 more PubMed ↗
Randomized trial BMC gastroenterology · 2025 Inulin-induced improvements on bowel habit and gut microbiota in adults with functional constipation: findings of a randomized, double-blind, placebo-controlled study. Puhlmann ML, Wegh CAM, van der Zalm SCC, et al. Faecalibacterium PubMed ↗
Randomized trial Movement disorders · 2025 Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial. Leta V, Zinzalias P, Batzu L, et al. Enterococcus faeciumLacticaseibacillus rhamnosusLactiplantibacillus plantarumLactobacillus acidophilus +1 more PubMed ↗
Review British journal of hospital medicine · 2025 The Role of Colonic Microbiota in Constipation Predominant Irritable Bowel Syndrome: A Literature Review. Roy YJ, Mirani Y, Raju J, et al. Escherichia coli PubMed ↗