Systematic review Frontiers in dental medicine · 2026 Effect of probiotic interventions on oral health in children: a systematic review. Bondre S, Shetty V, Kumari M, et al. Lacticaseibacillus paracaseiLacticaseibacillus rhamnosusLimosilactobacillus reuteri PubMed ↗
Randomized trial Gut microbes · 2026 Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study). Pasquier JC, Chaillet N, Plourde M, et al. Lacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2026 Effect of continuous energy restriction combined with probiotic supplementation on parameters related to homeostatic and hedonic systems of food intake in adult men living with obesity: Data from a randomized, parallel, double-blind, placebo-controlled clinical trial. Lucin GA, Marques CG, Magalhães ACO, et al. Bifidobacterium animalisLacticaseibacillus paracaseiLacticaseibacillus rhamnosusLactobacillus acidophilus PubMed ↗
Review Microorganisms · 2026 Burning Mouth Syndrome, the Oral Microbiome, and Lactic Acid Bacteria: A Comprehensive Review of Clinical Features, Microbial Dysbiosis, and Probiotic Therapeutic Potential. Jin YJ, Yoon JA, Ryu YJ Lacticaseibacillus paracasei PubMed ↗
Randomized trial Nutrients · 2026 A Heat-Inactivated Two-Strain Lacticaseibacillus paracasei Fermented Milk as a Postbiotic for Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial. Li X, Lan H, Guan Y, et al. Lacticaseibacillus paracasei PubMed ↗
Systematic review Biomolecules · 2026 Gut Microbiota Modulation as a Therapeutic Strategy for Insomnia: A Systematic Review of Nutritional and Botanical Interventions. Vicharnnikornkij N, Chaijaroenkul W, Bangchang KN Bifidobacterium breveLacticaseibacillus paracaseiLactiplantibacillus plantarumBacteroides PubMed ↗
Randomized trial Nutricion hospitalaria · 2026 Analysis of PNPLA3, TM6SF2 and GCKR gene polymorphisms in patients with metabolic dysfunction-associated steatohepatitis treated with probiotics ‒ An exploratory study. Beskow CB, Nasre-Nasser RG, Silva-Sperb AS, et al. Bifidobacterium animalisLacticaseibacillus paracaseiLacticaseibacillus rhamnosusLactobacillus acidophilus PubMed ↗
Randomized trial The American journal of clinical nutrition · 2026 Effects of 12-month probiotic supplementation on bone mineral density and bone turnover markers in early postmenopausal females: A double-blind randomized controlled trial. Resciniti S, Dacaya P, Yim K, et al. Lacticaseibacillus paracasei PubMed ↗
Review Current microbiology · 2026 Parabiotics as Next-Generation Microbiome Therapeutics: Insights into Mechanisms, Evidence, and Therapeutic Potential. Singh A, Bhattacharjee S, Singh Y, et al. Lacticaseibacillus paracaseiLactiplantibacillus plantarumLactobacillus acidophilus PubMed ↗
Review Microorganisms · 2026 Application and Research Prospects of CRISPR/Cas Gene Editing Technology in Lactic Acid Bacteria. Zhang E, Yan J, Du J, et al. Lacticaseibacillus paracasei PubMed ↗
Clinical trial Minerva gastroenterology · 2026 Efficacy of a probiotic-prebiotic mix on chronic constipation symptoms in the elderly: results of a pilot study. Montarsolo P, Barbagallo S, Fioravanti P, et al. Bifidobacterium animalisBifidobacterium breveLacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Review Cureus · 2026 Probiotic and Postbiotic Delivery Systems for the Management of Chronic Wounds: A Review of Emerging Strategies. Karmińska M, Czernikiewicz K, Głowacka-Kamińska W, et al. Bifidobacterium longumLacticaseibacillus paracaseiLimosilactobacillus reuteri PubMed ↗
Systematic review Clinical oral investigations · 2026 Probiotic supplementation and dental caries prevention in children and adolescents: a systematic review of strain-specific and context-dependent effects. Rodriguez G, Fernández Godoy E, Chaple Gil A, et al. Lacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Journal of microbiology and biotechnology · 2026 The Effect of a Probiotic on Gut Microbiota Stability and Systemic Well-Being during Short-Term Travel. Yang K, Yang M, Yu Q, et al. Bifidobacterium breveLacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Scientific reports · 2026 Efficacy of heat-treated Lacticaseibacillus paracasei PS23 for individuals with long coronavirus disease-19 syndrome: a double-blinded randomized control pilot study. Wu SI, Lin CJ, Lin YJ, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Journal of the World federation of orthodontists · 2026 Antimicrobial effects of four different probiotic compositions and delivery forms on clear aligner biofilm: A randomized single-blind crossover trial. Thakur V, Juneja A, Raza M, et al. Heyndrickxia coagulansLacticaseibacillus paracasei PubMed ↗
Systematic review Frontiers in oral health · 2025 The role of probiotics in preventing dental caries: a systematic review of clinical evidence. Inchingolo AD, Inchingolo AM, Palumbo I, et al. Bifidobacterium animalisLacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Arquivos de gastroenterologia · 2025 EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS. DE Souza GC, Araujo Filho HB, DE Oliveira CZ, et al. Bifidobacterium animalisBifidobacterium bifidumLacticaseibacillus paracaseiLactobacillus acidophilus PubMed ↗
Randomized trial American journal of reproductive immunology · 2025 Oral Lacticaseibacillus rhamnosus GG Exposure During Pregnancy and Effects on Maternal Inflammatory Response-A Blinded, Pilot Randomized, Placebo-Controlled Study. Nordqvist M, Hallingström M, Nerén A, et al. Lacticaseibacillus rhamnosusLacticaseibacillus paracasei PubMed ↗
Review Annals of vascular diseases · 2025 Role of Gut Microbes in Hypertension: A Systematic Review of Literature. Garde SS, Garde S Lacticaseibacillus paracaseiParabacteroides merdae PubMed ↗
Review Biochimica et biophysica acta. Reviews on cancer · 2025 Research progress on gut microbiota in colorectal cancer immunotherapy. Li J, Yue Y, Pan J, et al. Lacticaseibacillus paracasei PubMed ↗
Systematic review Frontiers in oral health · 2025 The efficacy of lactic acid bacteria-based toothpaste on oral health: a systematic review and meta-analysis. Choi EM, Park SK Lacticaseibacillus paracasei PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2025 Lactobacillus Paracasei CNCM I 1572 is Better than Placebo in Preventing Acute Diverticulitis Occurrence (Revised Manuscript 661a120f-b910-4133-ab7e-4bd3e1713c96). Tursi A, Picchio M, Elisei W, et al. Lacticaseibacillus paracasei PubMed ↗
Clinical trial Neuropsychiatric disease and treatment · 2025 Efficacy and Safety of Morinda Officinalis Oligosaccharides Combined with Probiotics as a Therapeutic Strategy for Major Depressive Disorder with Gastrointestinal Symptoms: A Randomized, Double-Blind, Controlled Clinical Trial. Zhou J, Wang X, Wang R, et al. Bifidobacterium animalisBifidobacterium bifidumLacticaseibacillus paracasei PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2025 The Effects of Lactobacillus paracasei NB23 on IGF-1, Muscle Function, and Cardiometabolic Risk Factors in Healthy Individuals: A Randomized Controlled Trial. Lin SW, Ko WS, Kuo FC, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2025 A Randomized, Double-Blind, Placebo-Controlled Study on Probiotic Treatment for Halitosis: Novel Insights into Glucose and Phosphorus Metabolism. Choi JH, Song S, Jang MJ, et al. Lacticaseibacillus paracaseiLactobacillus gasseri PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2025 Effects of probiotic supplementation on infectious and gastrointestinal complications of critically ill patients: Randomized, blinded, placebo-controlled clinical trial. Naslowski JB, Schieferdecker MEM, Campos ACL Bifidobacterium animalisLacticaseibacillus paracaseiLacticaseibacillus rhamnosusLactobacillus acidophilus PubMed ↗
Randomized trial The Journal of nutrition · 2025 Impact of Probiotic Lacticaseibacillus paracasei Strain Shirota (LcS) on Aflatoxin Exposure among Healthy Malaysian Adults: A Randomized, Double-Blind, Placebo-Controlled Intervention Study. Chang WL, Akiyama T, Wang JS, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2025 Assessing the Efficacy of Ligilactobacillus salivarius CLS0420 and Lacticaseibacillus paracasei CLPC0603 on Vaginal Well-Being in Healthy Women: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial. Kim SY, Seol D, Jeong M, et al. Lacticaseibacillus paracaseiLigilactobacillus salivarius PubMed ↗
Randomized trial World journal of gastroenterology · 2025 Randomized study of Lacticaseibacillus fermented milk in Indonesian elderly houses: Impact on gut microbiota and gut environment. Sujaya IN, Mariyatun M, Hasan PN, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial The Journal of nutrition · 2025 Effect of Daily Consumption of a Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota (LcS) on Stool Consistency in United States Adults with Hard or Lumpy Stools: A Randomized Controlled Trial. Cook CM, Akiyama T, Blonquist T, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Nutrients · 2025 Enhancement of Lower Limb Muscle Strength and Reduction of Inflammation in the Elderly: A Randomized, Double-Blind Clinical Trial Comparing Lacticaseibacillus paracasei PS23 Probiotic with Heat-Treated Supplementation. Lee MC, Hsu YJ, Yang HJ, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial PloS one · 2025 The efficacy of Lacticaseibacillus paracasei MSMC39-1 and Bifidobacterium animalis TA-1 probiotics in modulating gut microbiota and reducing the risk of the characteristics of metabolic syndrome: A randomized, double-blinded, placebo-controlled study. Luangphiphat W, Prombutara P, Jamjuree P, et al. Bifidobacterium animalisLacticaseibacillus paracaseiBlautia PubMed ↗
Randomized trial Journal of nutritional science and vitaminology · 2025 The Effect of Heat-Killed Lacticaseibacillus paracasei K71 on Abdominal Fat Reduction: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial. Yamamoto-Yamaya K, Senda-Sugimoto Y, Mihara T, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Clinical nutrition · 2024 Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, et al. Bifidobacterium animalisLacticaseibacillus paracaseiLacticaseibacillus rhamnosusLactobacillus acidophilus PubMed ↗
Randomized trial Scientific reports · 2024 Probiotic treatment induces changes in intestinal microbiota but does not alter SCFA levels in peritoneal dialysis patients-a randomized, placebo-controlled trial. Zhou S, Yan Y, Chu R, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Nutrients · 2024 Efficacy of Oral Probiotic Supplementation in Preventing Vulvovaginal Infections During Pregnancy: A Randomized and Placebo-Controlled Clinical Trial. Yefet E, Suleiman A, Colodner R, et al. Bifidobacterium animalisBifidobacterium bifidumLacticaseibacillus paracaseiLacticaseibacillus rhamnosus +2 more PubMed ↗
Review Gut microbes · 2024 Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects. Shah AB, Baiseitova A, Zahoor M, et al. Lacticaseibacillus paracaseiLacticaseibacillus rhamnosusLactiplantibacillus plantarumLactobacillus acidophilus +4 more PubMed ↗
Randomized trial International orthodontics · 2024 Effect of probiotic toothpaste and regular toothpaste on gingival health and plaque levels of adult orthodontic patients - An open label randomized controlled trial. Tahir K, Barakaat AA, Shoukat Ali U, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Food & function · 2024 Lacticaseibacillus paracasei 207-27 alters the microbiota-gut-brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial. Li J, Zhao J, Ze X, et al. Lacticaseibacillus paracaseiBacteroides PubMed ↗
Clinical trial Scientific reports · 2024 Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study. Andreozzi V, Cuoco S, Balestrieri M, et al. Faecalibacterium prausnitziiLacticaseibacillus paracasei PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2024 Assessment of the Effectiveness of Probiotics-assisted Physical Interventions in the Management of Chronic Periodontitis: A Randomized Controlled Clinical Trial. Wang L, Wang R, He Q, et al. Lacticaseibacillus paracaseiLactobacillus acidophilusLigilactobacillus salivarius PubMed ↗
Review The Pediatric infectious disease journal · 2024 Lacticaseibacillus paracasei Bacteremia Associated With Probiotic Use in a Child With Hypoganglionosis: Case Report and Literature Review. Ukai K, Okamoto K, Ichinose A, et al. Lacticaseibacillus paracasei PubMed ↗
Observational The oncologist · 2024 Optimizing abemaciclib-induced diarrhea management in patients with breast cancer: a pragmatic 2-group study using a postbiotic microbiota stabilizer. De Sanctis R, Tiberio P, Jacobs F, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Nutrients · 2024 Impact of Lactocaseibacillus (Lactobacillus) paracasei sup. paracasei TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial. Nuankham K, Sitdhipol J, Chonpathompikunlert P, et al. Lacticaseibacillus paracasei PubMed ↗
Clinical trial Urologia · 2024 Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study. Vittori M, Bove P, Signoretti M, et al. Bifidobacterium breveLacticaseibacillus paracaseiLactiplantibacillus plantarum PubMed ↗
Randomized trial Nutrients · 2024 Evaluating the Effect of Lacticaseibacillus paracasei Strain Shirota on the Physical Consistency of Stool in Healthy Participants with Hard or Lumpy Stools: A Double-Blind, Randomized, Placebo-Controlled Study. Tsujibe S, Gawad A, Shigehisa A, et al. Lacticaseibacillus paracasei PubMed ↗
Randomized trial Neonatology · 2024 The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Puisto R, Gómez-Gallego C, Collado MC, et al. Bifidobacterium longumLacticaseibacillus paracaseiLacticaseibacillus rhamnosus PubMed ↗
Randomized trial Journal of the science of food and agriculture · 2024 Effects of Lactocaseibacillus paracasei subsp. paracasei NTU 101 on gut microbiota: a randomized, double-blind, placebo-controlled clinical study. Lin TH, Shih TW, Lin CH Lacticaseibacillus paracasei PubMed ↗
Randomized trial Nutrients · 2024 The Effect of the Lacticaseibacillus paracasei BEPC22 and Lactiplantibacillus plantarum BELP53 Combination (BN-202M) on Body Fat Percentage Loss in Overweight Individuals: A Randomized, Double-Blind, Placebo-Controlled Study. Kwon HS, Kim SJ, Shin KJ, et al. Lacticaseibacillus paracaseiLactiplantibacillus plantarum PubMed ↗