Randomized trial Gut microbes · 2026 Effect of pasteurized Akkermansia muciniphila MucT on insulin sensitivity, body composition, and GLP-1 production in subjects with metabolic syndrome: impact of low baseline gut Akkermansia levels. Suenaert P, Segers A, Rymenans L, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Nature metabolism · 2025 Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes. Chu NHS, Ling J, Poon EWM, et al. Butyricimonas virosaDorea formicigenerans PubMed ↗
Randomized trial Gut microbes · 2025 Anaerobutyricum soehngenii improves glycemic control and other markers of cardio-metabolic health in adults at risk of type 2 diabetes. Attaye I, Bird JK, Nieuwdorp M, et al. Anaerobutyricum soehngeniiAnaerobutyricum hallii PubMed ↗
Observational Nature medicine · 2025 Microbiome-metabolome dynamics associated with impaired glucose control and responses to lifestyle changes. Wu H, Lv B, Zhi L, et al. Blautia wexlerae PubMed ↗
Randomized trial International journal of biological macromolecules · 2024 Effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in prediabetes: A randomized controlled trial. Liu Y, Xu Z, Zhang D, et al. Blautia PubMed ↗
Observational Metabolic syndrome and related disorders · 2024 Quantification and Correlation Analysis of Bacteroides Species with Diabetes-Related Amino Acids in Individuals with Prediabetes and Type 2 Diabetes Mellitus. Safari-Alighiarloo N, Bostanghadiri N, Sedighi M, et al. Bacteroides thetaiotaomicronPhocaeicola vulgatus PubMed ↗
Randomized trial Nutrients · 2024 Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study. Beteri B, Barone M, Turroni S, et al. Bifidobacterium breve PubMed ↗
Observational Scientific reports · 2024 Effect of metformin and metformin/linagliptin on gut microbiota in patients with prediabetes. Martínez-López YE, Neri-Rosario D, Esquivel-Hernández DA, et al. Blautia PubMed ↗
Meta-analysis Clinical nutrition ESPEN · 2024 Effects of Lactobacillus plantarum supplementation on glucose and lipid metabolism in type 2 diabetes mellitus and prediabetes: A systematic review and meta-analysis of randomized controlled trials. Zhong H, Wang L, Jia F, et al. Lactiplantibacillus plantarum PubMed ↗
Randomized trial Diabetes, obesity & metabolism · 2024 Ingesting probiotic yogurt containing Lactiplantibacillus plantarum OLL2712 improves glycaemic control in adults with prediabetes in a randomized, double-blind, placebo-controlled trial. Toshimitsu T, Gotou A, Sashihara T, et al. Lactiplantibacillus plantarum PubMed ↗
Randomized trial Nutrients · 2023 Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes. Mathrani A, Yip W, Sequeira-Bisson IR, et al. Roseburia inulinivorans PubMed ↗
Randomized trial The Turkish journal of gastroenterology · 2022 Metformin with Versus without Concomitant Probiotic Therapy in Newly Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects, and Treatment Compliance. Şahin K, Şahintürk Y, Köker G, et al. Bifidobacterium animalis PubMed ↗
Observational Frontiers in endocrinology · 2022 Integrating Choline and Specific Intestinal Microbiota to Classify Type 2 Diabetes in Adults: A Machine Learning Based Metagenomics Study. Zeng Q, Zhao M, Wang F, et al. [Ruminococcus] lactarisCoprococcus catusSegatella copri PubMed ↗
Randomized trial The Journal of nutrition · 2022 Red Raspberry and Fructo-Oligosaccharide Supplementation, Metabolic Biomarkers, and the Gut Microbiota in Adults with Prediabetes: A Randomized Crossover Clinical Trial. Zhang X, Zhao A, Sandhu AK, et al. Blautia wexleraeLachnospira eligensMediterraneibacter gnavus PubMed ↗
Clinical trial Genome medicine · 2022 Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study. Jian C, Silvestre MP, Middleton D, et al. Blautia PubMed ↗
Randomized trial BMJ open · 2022 A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes. Barthow C, Hood F, Crane J, et al. Lacticaseibacillus rhamnosus PubMed ↗
Observational The Journal of clinical endocrinology and metabolism · 2022 The Gut Microbiome Modifies the Association Between a Mediterranean Diet and Diabetes in USA Hispanic/ Latino Population. Wang DD, Qi Q, Wang Z, et al. Faecalibacterium prausnitzii PubMed ↗
Randomized trial Nutrients · 2021 Lactobacillus plantarum HAC01 Supplementation Improves Glycemic Control in Prediabetic Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. Oh MR, Jang HY, Lee SY, et al. Lactiplantibacillus plantarum PubMed ↗
Observational Genome medicine · 2021 Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark. Pinna NK, Anjana RM, Saxena S, et al. BacteroidesFaecalibacterium PubMed ↗
Carbohydrate polymers · 2026 Structure-function relationship of Konjac glucomannan with varying acetylation degrees in modulating gut microbiota and alleviating prediabetes. Wang H, Zhao Y, Dang D, et al. Bacteroides uniformis PubMed ↗
Microbiology spectrum · 2025 Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals. Liu Y, Qiu Q, Chen Y, et al. Flavonifractor plautiiParabacteroides merdae PubMed ↗
Diabetes · 2023 A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. Nogal A, Tettamanzi F, Dong Q, et al. [Ruminococcus] torquesDorea formicigeneransFaecalibacillus intestinalis PubMed ↗
Frontiers in endocrinology · 2023 Dysbiosis signatures of gut microbiota and the progression of type 2 diabetes: a machine learning approach in a Mexican cohort. Neri-Rosario D, Martínez-López YE, Esquivel-Hernández DA, et al. Blautia PubMed ↗
BMJ open diabetes research & care · 2023 Strains of Faecalibacterium prausnitzii and its extracts reduce blood glucose levels, percent HbA1c, and improve glucose tolerance without causing hypoglycemic side effects in diabetic and prediabetic mice. Kallassy J, Gagnon E, Rosenberg D, et al. Faecalibacterium prausnitzii PubMed ↗
Nutrients · 2023 High Fructose Causes More Prominent Liver Steatohepatitis with Leaky Gut Similar to High Glucose Administration in Mice and Attenuation by Lactiplantibacillus plantarum dfa1. Ondee T, Pongpirul K, Udompornpitak K, et al. Lactiplantibacillus plantarum PubMed ↗
Human antibodies · 2021 Blood microbiota composition in Iranian pre-diabetic and type 2 diabetic patients. Ghaemi F, Fateh A, Sepahy AA, et al. Bacteroides fragilisEscherichia coliFaecalibacterium PubMed ↗
Animal study Life sciences · 2022 Lactobacillus rhamnosus supplementation ameliorates high fat diet-induced epigenetic alterations and prevents its intergenerational inheritance. Sheth VG, Sharma N, Kabeer SW, et al. Lacticaseibacillus rhamnosus PubMed ↗
Animal study Scientific reports · 2021 Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice. Bravard A, Gérard C, Defois C, et al. Akkermansia muciniphila PubMed ↗