Systematic review Journal of oral pathology & medicine · 2026 Oral and Pancreatobiliary Microbiota in Cancer: A Systematic Review of Compositional Alterations and Their Clinical Implications. Fariba E, Rosanna V, Domenico C, et al. FusobacteriumVeillonella PubMed ↗
Observational Cancer medicine · 2026 Characterization of the Oral Bacteria in Patients With Neuroendocrine Tumors of the Pancreas. Yao J, Fei C, Wu H, et al. Actinomyces PubMed ↗
Observational International journal of surgery · 2025 Microbial variations in the multibody sites of the pancreatic ductal adenocarcinoma patients. Zhu Y, Zhi M, Liang X, et al. Akkermansia muciniphilaFaecalibacterium prausnitziiMegasphaera PubMed ↗
Observational JAMA oncology · 2025 Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer. Meng Y, Wu F, Kwak S, et al. EubacteriumFusobacteriumPrevotella PubMed ↗
Observational Scientific reports · 2025 Machine learning models for pancreatic cancer diagnosis based on microbiome markers from serum extracellular vesicles. Lee D, Lee C, Han K, et al. AkkermansiaClostridiumTuricibacter PubMed ↗
Observational Cancer letters · 2025 Elevated levels of circulating microbial-associated uremic toxins are associated with metastatic duodenopancreatic neuroendocrine tumors in patients with Multiple Endocrine Neoplasia Type 1. Ballarò R, Wasylishen AR, Pieterman CRC, et al. Faecalibacterium prausnitziiKlebsiella pneumoniaeStreptococcus thermophilus PubMed ↗
Observational Cancer letters · 2025 Oral and fecal microbiota as accurate non-invasive tools for detection of pancreatic cancer in the Chinese population. Li P, Zhang H, Chen L, et al. AkkermansiaBifidobacteriumStreptococcus PubMed ↗
Observational Journal of translational medicine · 2025 Metagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case-control study. Oh S, Kim J, Shin CM, et al. ActinomycesAkkermansiaEscherichiaEubacterium +3 more PubMed ↗
Review Pathogens · 2024 Intratumoral Fusobacterium nucleatum in Pancreatic Cancer: Current and Future Perspectives. D'Antonio DL, Zenoniani A, Umme S, et al. Fusobacterium PubMed ↗
Observational Scientific reports · 2024 Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study. Daniel N, Farinella R, Chatziioannou AC, et al. Romboutsia PubMed ↗
Observational Pancreatology · 2024 Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer. Sono M, Iimori K, Nagao M, et al. HoldemanellaStreptococcus PubMed ↗
Meta-analysis International journal of surgery · 2024 Gut microbiome changes associated with chronic pancreatitis and pancreatic cancer: a systematic review and meta-analysis. Hong J, Fu Y, Chen X, et al. CoprococcusEscherichiaVeillonella PubMed ↗
Randomized trial Nutrients · 2024 Efficacy of 1-Kestose Supplementation in Patients with Pancreatic Ductal Adenocarcinoma: A Randomized Controlled Pilot Study. Nakaoka K, Ohno E, Kuramitsu K, et al. Escherichia coli PubMed ↗
Review Frontiers in immunology · 2024 Unraveling the gut microbiome's contribution to pancreatic ductal adenocarcinoma: mechanistic insights and therapeutic perspectives. Tabrizi E, Pourteymour Fard Tabrizi F, Mahmoud Khaled G, et al. Fusobacterium PubMed ↗
Review Archives of microbiology · 2024 Postbiotic butyrate: role and its effects for being a potential drug and biomarker to pancreatic cancer. Elango A, Nesam VD, Sukumar P, et al. Faecalibacterium PubMed ↗
Meta-analysis Annals of surgical oncology · 2023 Does Oral Microbiota Have a Close Relationship with Pancreatic Cancer? A Systematic Review and Meta-Analysis. Ma H, Luo W, Gu Y Prevotella PubMed ↗
Observational Cancer · 2023 Analysis of the fecal metagenome in long-term survivors of pancreas cancer. Kharofa J, Haslam D, Wilkinson R, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Systematic review Clinics · 2022 MICRObiota on BILIOpancreatic malignant diseases [MICROBILIO]: A systematic review. Mattos VC, Nascimento FSD, Suzuki MO, et al. Escherichia PubMed ↗
Observational Scandinavian journal of gastroenterology · 2022 Changes in intestinal bacteria and imbalances of metabolites induced in the intestines of pancreatic ductal adenocarcinoma patients in a Japanese population: a preliminary result. Hashimoto S, Tochio T, Funasaka K, et al. ActinomycesAnaerostipesVeillonella PubMed ↗
Randomized trial BMC anesthesiology · 2022 Influence of different regimens of volumetric therapy on perioperative intestinal flora in the surgical patients with pancreas tumor, a randomized controlled trial study. Lu X, Wang Y, Luo Y, et al. DialisterEnterococcusRoseburia PubMed ↗
Review Nutrients · 2021 Pancreatic Cancer and Gut Microbiome-Related Aspects: A Comprehensive Review and Dietary Recommendations. Sobocki BK, Kaźmierczak-Siedlecka K, Folwarski M, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Review Gan to kagaku ryoho. Cancer & chemotherapy · 2021 [Intestinal Care Using L‒Glutamine Supplement and Probiotics Can Induce a Strong Anti‒Tumor Immune Response through the Induction of Mature Tertiary Lymphoid Structures in Pancreatic Cancer Patients Receiving Preoperative Chemotherapy]. Ohta T, Makino I, Okazaki M, et al. Clostridium butyricum PubMed ↗
Medicine · 2026 Exploration of the mechanism of gut microbiota-mediated immune modulation in the pathogenesis of pancreatic cancer: A Mendelian randomization study. Cai M, Cheng H, Jia Y, et al. Ruminococcus PubMed ↗
Science advances · 2026 Engineered probiotic Bifidobacterium for tumor-targeted pancreatic cancer therapy. Lee J, Yang K, Nowicki CA, et al. Bifidobacterium longum PubMed ↗
mBio · 2026 Potential mechanisms underlying Enterococcus faecalis-driven pancreatic cancer cell proliferation. Guan M, Guo X, Kong M, et al. Enterococcus faecalis PubMed ↗
Journal of translational medicine · 2026 Intratumoral microbiota promote pancreatic cancer progression via NaAc-mediated activation of the GPR43/AMPK/HADH pathway. Chen Z, Jin D, Wang H, et al. Blautia PubMed ↗
Clinical and experimental medicine · 2026 Dynamic changes in gut microbiota and discovery of prognostic biomarkers in locally advanced pancreatic cancer during chemoradiotherapy. Wang H, Wang F, Guo Q, et al. Bacteroides PubMed ↗
Journal of extracellular vesicles · 2026 The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization. Wang J, Maitiabula G, Liu S, et al. Agathobacter rectalis PubMed ↗
Scientific reports · 2026 Multi-omics and network pharmacology reveal the mechanisms of Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang against pancreatic cancer. Zhao Z, Yang Y, Zhang L, et al. Bacteroides caccae PubMed ↗
Cell host & microbe · 2026 Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy. Li B, Liu G, Zhu Y, et al. Bifidobacterium longum PubMed ↗
BMC cancer · 2025 Analysis of the predictive effect of gut microbiota changes on the occurrence of chemotherapy resistance in pancreatic cancer patients based on nomogram prediction models. Li Y, Liu S, Lai X, et al. Enterococcus faecalisEscherichia coliAkkermansiaBifidobacterium +1 more PubMed ↗
Scientific reports · 2025 Integrative analysis of pancreatic microbiota and metabolome in patients with pancreatic ductal adenocarcinoma. Zhu Y, Liang X, Li F, et al. CoprococcusFaecalibacteriumRuminococcusSubdoligranulum PubMed ↗
Frontiers in cellular and infection microbiology · 2025 Gut-to-tumor translocation of multidrug-resistant Klebsiella pneumoniae shapes the microbiome and chemoresistance in pancreatic cancer. Zhao L, Peng S, Ge M, et al. Klebsiella pneumoniaeAkkermansia muciniphila PubMed ↗
Cellular and molecular gastroenterology and hepatology · 2025 Probiotics Mitigate High-cholesterol Diet-driven Fatty Liver and Pancreatic Cancer by Restoring Macrophage Homeostasis. Parida D, Mishra S, Mohapatra AP, et al. Lacticaseibacillus rhamnosusLactiplantibacillus plantarum PubMed ↗
BMC microbiology · 2025 Oral and fecal microbiome alterations in pancreatic cancer: insights into potential diagnostic biomarkers. Tavanaeian S, Feizabadi MM, Falsafi S, et al. Bifidobacterium bifidumRoseburia intestinalisFusobacterium PubMed ↗
Cellular oncology · 2025 Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects. Tong Y, Li Q, Zhang W, et al. Eggerthella lentaParasutterella excrementihominisSutterella PubMed ↗
International immunopharmacology · 2025 Intratumoral microbiota-driven macrophage reprogramming in pancreatic cancer via Blautia metabolite 6-hydroxyhexanoic acid. Zhong Y, Zhang D, Ding F, et al. Blautia PubMed ↗
Neuroendocrinology · 2025 The Causal Role of Gut Microbiota and Immune Cell Mediation in Gastroenteropancreatic Neuroendocrine Neoplasms: A Mendelian Randomization Study. Jiang Z, Ma P, Wang F, et al. ClostridiumParaprevotellaRoseburia PubMed ↗
Biomolecules · 2025 Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer. Xu G, Jiang Y, Sun C, et al. Enterococcus faecalis PubMed ↗
BMC microbiology · 2025 Dynamic changes of gut and skin microbiota in pancreatic cancer-induced skin injury. Yao S, Yan X, Chen H, et al. BlautiaParasutterella PubMed ↗
Frontiers in cellular and infection microbiology · 2025 Microbiological colonization of the pancreatic tumor affects postoperative complications and outcome after pancreatic surgery. Biesel EA, Sundheimer J, Badr MT, et al. Enterococcus faecalisEnterococcus faecium PubMed ↗
Scientific reports · 2025 Biliary microbiome profiling via 16 S rRNA amplicon sequencing in patients with cholangiocarcinoma, pancreatic carcinoma and choledocholithiasis. Mizutani H, Fukui S, Oosuka K, et al. Streptococcus PubMed ↗
Cancer letters · 2025 Microbiome, metabolome, and ionome profiling of cyst fluids reveals heterogeneity in pancreatic cystic neoplasms. Yang S, Hu Y, Cui M, et al. Streptococcus PubMed ↗
Medicina · 2025 Gut Microbiota-Based Immunotherapy: Engineered Escherichia coli Nissle 1917 for Oral Delivery of Glypican-1 in Pancreatic Cancer. Vruzhaj I, Gambirasi M, Busato D, et al. Escherichia coli PubMed ↗
European journal of gastroenterology & hepatology · 2025 Distinct composition and metabolic potential of biliary microbiota in patients with malignant bile duct obstruction. Qian L, Wang L, Zou Z, et al. ClostridiumTuricibacter PubMed ↗
Gut microbes · 2025 Upregulation of Lactobacillus spp. in gut microbiota as a novel mechanism for environmental eustress-induced anti-pancreatic cancer effects. Liang Y, Du M, Li X, et al. Limosilactobacillus reuteri PubMed ↗
BMC microbiology · 2024 Microbiome and metabolome analysis in smoking and non-smoking pancreatic ductal adenocarcinoma patients. Liang X, Zhu Y, Bu Y, et al. FaecalibacteriumVeillonella PubMed ↗
Small · 2024 Harnessing the Engineered Probiotic-Nanosystem to Remodulate Tumor Extracellular Matrix and Regulate Tumor-Colonizing Bacteria for Improving Pancreatic Cancer Chemo-Immunotherapy. Yao WQ, Song WF, Deng XC, et al. Clostridium butyricum PubMed ↗
Frontiers in immunology · 2024 Succession of the multi-site microbiome along pancreatic ductal adenocarcinoma tumorigenesis. Zhu Y, Liang X, Zhi M, et al. Bifidobacterium breveLactiplantibacillus plantarum PubMed ↗
International journal of molecular sciences · 2024 Metagenomic Study Reveals Phage-Bacterial Interactome Dynamics in Gut and Oral Microbiota in Pancreatic Diseases. Vilà-Quintana L, Fort E, Pardo L, et al. FusobacteriumStreptococcus PubMed ↗