probiome Sign in

PubMed · human studies and reviews first

Research

31 papers

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2016 and later Osteoporosis Clear all

Review Gut microbes · 2026

The gut-bone axis: microbial metabolism and nutritional interventions for bone health.

Rodriguez-Bryant A, Papageorgiou M, Horcajada MN, et al.

Bifidobacterium animalis

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Observational The American journal of clinical nutrition · 2025

Merrill LC, Martínez RL, Palacios N, et al.

Lachnospira eligens

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Systematic review Bone · 2025

The role of probiotics in modulating RANKL in osteoporosis: A systematic review of animal interventional studies and RCTs.

Hamedi-Kalajahi F, Alizadeh M, Kheirouri S

Bifidobacterium longum

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Review Diabetes/metabolism research and reviews · 2025

Diabetes and Bone Health: A Comprehensive Review of Impacts and Mechanisms.

Upadhyay P, Kumar S

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Observational Scientific reports · 2024

Associations between gut microbiota and osteoporosis or osteopenia in a cohort of Chinese Han youth.

Lai J, Gong L, Liu Y, et al.

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Cells · 2026

Genome-Resolved Functional Profiling of Osteoporosis-Associated Gut Bacteria Highlights Putative Metabolic and Immunogenic Signatures of the Gut-Bone Axis.

Jiménez-Ortega RF, Ortega-Meléndez AI, Montes-García JF, et al.

Dialister invisus

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Communications biology · 2026

Roseburia intestinalis-derived extracellular vesicles alleviate osteoporosis through gut microbiota-regulated histidylleucine via Akt/FOXO1 signaling.

Lu J, Liu Y, Chen J, et al.

Roseburia intestinalis

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Microbiological research · 2025

Androgen deficiency-induced loss of Lactobacillus salivarius extracellular vesicles is associated with the pathogenesis of osteoporosis.

Zhang W, Xie J, Wang Z, et al.

Ligilactobacillus salivarius

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Bone · 2024

Investigating the link between gut microbiome and bone mineral density: The role of genetic factors.

Gao N, Zhuang Y, Zheng Y, et al.

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Journal of agricultural and food chemistry · 2024

Konjac Oligosaccharides Alleviated Ovariectomy-Induced Bone Loss through Gut Microbiota Modulation and Treg/Th17 Regulation.

Ai T, Shang L, Li B, et al.

Bifidobacterium longum

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Food & function · 2024

Bifidobacterium improves oestrogen-deficiency-induced osteoporosis in mice by modulating intestinal immunity.

Zhang J, Liang X, Tian X, et al.

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Nature communications · 2023

Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways.

Lin X, Xiao HM, Liu HM, et al.

Phocaeicola vulgatus

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Nature communications · 2023

Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study.

Grahnemo L, Nethander M, Coward E, et al.

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Genes · 2022

Gut Microbiota Feature of Senile Osteoporosis by Shallow Shotgun Sequencing Using Aged Rats Model.

Wang N, Ma S, Fu L

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Advanced science · 2021

Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength.

Liu JH, Chen CY, Liu ZZ, et al.

Akkermansia muciniphila

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Animal study Life sciences · 2026

Akkermansia muciniphila alleviates osteoporosis by suppressing bone marrow adiposity through the gut microbiota-UDCA-TGR5 axis.

Hao F, Zhu W, Tang A, et al.

Akkermansia muciniphila

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Animal study Current microbiology · 2026

Combined Supplementation with Streptococcus Thermophilus Yilife-SST 01 and Bifidobacterium Bifidum BL-99 Mitigates Unloading-Induced Osteoporosis in Rats.

Guo L, Li B, Liu S, et al.

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Animal study Advanced science · 2026

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis.

Rao SS, Zeng HJ, Wang Z, et al.

Akkermansia muciniphila

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Animal study Advanced healthcare materials · 2026

Delivery System Based on Akkermansia Muciniphila Loaded Salidroside for the Treatment of Osteoporosis in Zebrafish Model.

Ma J, Ruan J, Yi J, et al.

Akkermansia muciniphila

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Animal study Journal of dairy science · 2025

Butyrate-producing Lactococcus lactis-fermented goat cheese enhances bone health and reduces osteoporotic bone loss.

Liu S, Li C, Lv Y, et al.

Lactococcus lactis

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Animal study mSphere · 2025

Bifidobacterium longum increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice.

Wang H, Tian G, Pei Z, et al.

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Animal study PloS one · 2025

Integrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites.

Li Q, Wu X, Niu X, et al.

Akkermansia muciniphila

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Animal study Journal of bone and mineral metabolism · 2024

Assessing the effects of probiotic supplementation, single strain versus mixed strains, on femoral mineral density and osteoblastic gene mRNA expression in rats.

Parvaneh M, Jamaluddin R, Ebrahimi M, et al.

Bifidobacterium longum

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Animal study Journal of periodontal research · 2024

Probiotics enhance alveolar bone microarchitecture, intestinal morphology and estradiol levels in osteoporotic animals.

Lucateli RL, Silva PHF, Salvador SL, et al.

Bifidobacterium animalis

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Animal study Food & function · 2022

Bifidobacterium lactis BL-99 protects mice with osteoporosis caused by colitis via gut inflammation and gut microbiota regulation.

Lan H, Liu WH, Zheng H, et al.

Bifidobacterium animalis

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Animal study BMC complementary medicine and therapies · 2021

Exploring the bone sparing effects of postbiotics in the post-menopausal rat model.

Montazeri-Najafabady N, Ghasemi Y, Dabbaghmanesh MH, et al.

Bifidobacterium longum

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Probiotics and antimicrobial proteins · 2019

Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss.

Montazeri-Najafabady N, Ghasemi Y, Dabbaghmanesh MH, et al.

Bifidobacterium longum

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Journal of medicinal food · 2019

Lactobacillus plantarum NK3 and Bifidobacterium longum NK49 Alleviate Bacterial Vaginosis and Osteoporosis in Mice by Suppressing NF-κB-Linked TNF-α Expression.

Kim DE, Kim JK, Han SK, et al.

Bifidobacterium longum

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Animal study Journal of applied microbiology · 2020

Lactobacillus-fermented milk products attenuate bone loss in an experimental rat model of ovariectomy-induced post-menopausal primary osteoporosis.

Lee CS, Kim JY, Kim BK, et al.

Faecalibacterium prausnitzii

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Animal study American journal of physiology. Endocrinology and metabolism · 2020

Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss.

Lawenius L, Scheffler JM, Gustafsson KL, et al.

Akkermansia muciniphila

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Animal study Nutrients · 2018

Bone Response to Dietary Co-Enrichment with Powdered Whole Grape and Probiotics.

Blanton C

Bifidobacterium bifidum

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