Randomized trial Frontiers in cellular and infection microbiology · 2026 Gut microbial dynamics and antibiotic resistance during rifaximin therapy in severe cirrhosis: a ProPILA-Rifax ancillary study. Ladeira R, Biguenet A, Meunier A, et al. Blautia obeumEscherichia coliRuminococcus bromiiVeillonella PubMed ↗
Observational Clinical and translational gastroenterology · 2026 Alterations in the Gut Microbiota of Cirrhotic Patients With Sarcopenia and PH After TIPS. Wang H, Cao Y, Zhang X, et al. ButyricimonasFaecalibacteriumFusicatenibacterIntestinibacter +4 more PubMed ↗
Randomized trial Alimentary pharmacology & therapeutics · 2026 Rifaximin Improves Cognitive Performance and Reduces Cirrhosis-Related Adverse Events in Covert Hepatic Encephalopathy: A Randomized Controlled Trial. Inada H, Toyota T, Uojima H, et al. Eubacterium PubMed ↗
Review The lancet. Gastroenterology & hepatology · 2026 Rifaximin in cirrhosis: when therapeutic drift meets antimicrobial stewardship. Jalan R, Patel VC, Shoaie S Enterococcus faecium PubMed ↗
Observational Journal of gastroenterology and hepatology · 2026 Gut Microbiome Signatures Differ in Cirrhosis With and Without Hepatocellular Carcinoma in a Southeast Asian Cohort. Jinato T, Sikaroodia M, Gilleveta PM, et al. Mediterraneibacter gnavusAlloprevotellaCatenibacteriumCoprococcus +2 more PubMed ↗
Randomized trial Canadian journal of gastroenterology & hepatology · 2026 Rifaximin Plus Probiotics Reshape Gut Microbiota, Serum Propionate, and Mucosal Immunity in Cirrhosis-Related Hepatic Encephalopathy Microbiota-Immune Remodeling in HE. Wang Y, Zhu H, Wang S, et al. Bacteroides ovatusLigilactobacillus salivarius PubMed ↗
Observational Journal of translational medicine · 2025 Intestinal congestion-driven gut dysbiosis: a cross-disease hemodynamic mechanism in liver cirrhosis and heart failure. Wang Y, Bai Z, Sun J, et al. CoprococcusVeillonella PubMed ↗
Observational Scientific reports · 2025 Diagnostic significance of gut Microbiome dysbiosis and biomarker expression in Egyptians with hepatocellular carcinoma. Marawan AE, Elmetwally OA, Marwan MM, et al. FusobacteriumPorphyromonas PubMed ↗
Randomized trial Liver international · 2025 A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention. Vega-Abellaneda S, Román E, Soler Z, et al. Akkermansia muciniphilaLactobacillus acidophilusStreptococcus thermophilusBacteroides +2 more PubMed ↗
Observational Clinical and translational gastroenterology · 2025 Fecal Microbiota and Bile Acid Profiles in Early-Stage Hepatocellular Carcinoma: A Matched Case-Control Study. Nobel YR, Park H, Tillman AM, et al. Klebsiella pneumoniae PubMed ↗
Observational Clinical nutrition · 2025 An observational study on the effect of l-ornithine-l-aspartate (LOLA) on the gut microbiome in liver cirrhosis. A single center phase 4 study. Habich D, Horvath A, Feldbacher N, et al. EnterococcusFlavonifractorRomboutsia PubMed ↗
Observational Frontiers in immunology · 2025 Featured intestinal microbiota associated with hepatocellular carcinoma in various liver disease states. Sun X, Zhou Z, Chi X, et al. FaecalibacteriumHaemophilusKlebsiellaMegasphaera +5 more PubMed ↗
Randomized trial Liver international · 2025 Probiotics Prevent Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomised Controlled Trial. Quan X, Li Y, Ye X, et al. Bifidobacterium PubMed ↗
Observational BMC gastroenterology · 2025 Relationship between gut microbiota dysbiosis and bile acid in patients with hepatitis B-induced cirrhosis. Li Y, Zhang D, Tian T, et al. Veillonella PubMed ↗
Observational Hepatology · 2025 Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multicenter cirrhosis outpatient cohort. Bajaj JS, Reddy KR, Tandon P, et al. HaemophilusPrevotellaStreptococcusVeillonella PubMed ↗
Clinical trial The American journal of gastroenterology · 2025 Microbial Dysbiosis in the Urinary Microbiome of Patients With Cirrhosis. Woltsche J, Pacher-Deutsch C, Fürst S, et al. Streptococcus PubMed ↗
Observational The Journal of clinical investigation · 2025 Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice. Li J, Xie S, Chen M, et al. Megamonas PubMed ↗
Observational Frontiers in cellular and infection microbiology · 2025 Distinct gut microbiota and metabolomic profiles in HBV-related liver cirrhosis: insights into disease progression. Shi K, Sun L, Feng Y, et al. AlistipesEnterococcusFusobacteriumLachnospira PubMed ↗
Observational mSphere · 2025 Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses. Majernik SN, Beaver L, Bradley PH Lachnospira eligensHaemophilusVeillonella PubMed ↗
Observational Scientific reports · 2025 Gut microbiota analysis in cirrhosis and non-cirrhotic portal hypertension suggests that portal hypertension can be main factor of cirrhosis-specific dysbiosis. Gulyaeva K, Nadinskaia M, Maslennikov R, et al. CatenibacteriumEnterococcusEscherichiaFaecalibacterium +5 more PubMed ↗
Meta-analysis BMC gastroenterology · 2025 Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis. Liu Y, Chen Z, Li C, et al. HaemophilusStreptococcusVeillonella PubMed ↗
Systematic review International journal of molecular sciences · 2025 A Systematic Review of Microbiota in Cirrhosis: A Change Towards a More Pathogenic Predisposition. Xirouchakis E, Pelekanos A, Xirouchakis S, et al. EnterococcusEscherichiaStreptococcus PubMed ↗
Observational Environmental health and preventive medicine · 2025 A 4-year cohort study of the effects of PNPLA3 rs738409 genotypes on liver fat and fibrosis and gut microbiota in a non-fatty liver population. Sato S, Iino C, Sasada T, et al. Blautia PubMed ↗
Observational World journal of gastroenterology · 2024 Alterations in the gut microbiome after transjugular intrahepatic portosystemic shunt in patients with hepatitis B virus-related portal hypertension. Zhao HW, Zhang JL, Liu FQ, et al. AllisonellaAnaerostipesBilophilaButyricicoccus +6 more PubMed ↗
Randomized trial Journal of digestive diseases · 2024 Impact of rifaximin on cirrhosis complications and gastric microbiota in patients with gastroesophageal variceal bleeding: A pilot randomized controlled trial. Huang XQ, Ai YJ, Li F, et al. Collinsella PubMed ↗
Randomized trial Clinical nutrition ESPEN · 2024 Probiotics may be useful for drug-induced liver dysfunction in patients with depression - A secondary analysis of a randomized clinical trial. Gawlik-Kotelnicka O, Burzyński J, Rogalski J, et al. Bifidobacterium longumLactobacillus helveticus PubMed ↗
Observational Clinical and molecular hepatology · 2024 Gut microbiome and metabolome signatures in liver cirrhosis-related complications. Sharma SP, Gupta H, Kwon GH, et al. [Clostridium] symbiosumBacteroides ovatusMediterraneibacter gnavusFusobacterium +3 more PubMed ↗
Review Journal of gastroenterology · 2024 Gut microbiota and metabolites of cirrhotic portal hypertension: a novel target on the therapeutic regulation. Hao Y, Hao Z, Zeng X, et al. Alistipes putredinisRoseburia faecisVeillonella disparClostridium PubMed ↗
Observational The Kaohsiung journal of medical sciences · 2024 Exploring the diagnostic potential of immunoglobulin A-microbiota interplay in liver cirrhosis and spontaneous bacterial peritonitis. Zhang LJ, Huang WQ, Zhang Y, et al. Faecalibacterium PubMed ↗
Randomized trial World journal of gastroenterology · 2024 Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis. Hu YC, Ding XC, Liu HJ, et al. Lacticaseibacillus paracasei PubMed ↗
Observational Gut microbes · 2023 Alterations in gut virome are associated with cognitive function and minimal hepatic encephalopathy cross-sectionally and longitudinally in cirrhosis. Jinato T, Sikaroodi M, Fagan A, et al. Faecalibacterium PubMed ↗
Systematic review Frontiers in cellular and infection microbiology · 2023 Convergent application of traditional Chinese medicine and gut microbiota in ameliorate of cirrhosis: a data mining and Mendelian randomization study. Zhou C, Wei J, Yu P, et al. Veillonella PubMed ↗
Randomized trial Chinese journal of integrative medicine · 2023 Efficacy of Biejiajian Pill on Intestinal Microbiota in Patients with Hepatitis B Cirrhosis/Liver Fibrosis: A Randomized Double-Blind Controlled Trial. Chi X, Cheng DY, Sun X, et al. BlautiaFaecalibacteriumParabacteroidesPrevotella +1 more PubMed ↗
Randomized trial The Journal of nutrition · 2023 Probiotic Supplementation, Hepatic Fibrosis, and the Microbiota Profile in Patients with Nonalcoholic Steatohepatitis: A Randomized Controlled Trial. Escouto GS, Port GZ, Tovo CV, et al. Bifidobacterium animalisLactobacillus acidophilus PubMed ↗
Systematic review Journal of applied microbiology · 2023 The critical role of gut microbiota dysbiosis in skeletal muscle wasting: a systematic review. Nikkhah A, Ejtahed HS, Ettehad Marvasti F, et al. FusicatenibacterLachnoclostridiumLachnospiraRoseburia PubMed ↗
Meta-analysis Medicine · 2022 Alterations of gut microbiome and effects of probiotic therapy in patients with liver cirrhosis: A systematic review and meta-analysis. Huang L, Yu Q, Peng H, et al. BifidobacteriumEnterococcusLactobacillus PubMed ↗
Observational PloS one · 2022 Evaluation of metabolic dysfunction-associated fatty liver disease using FibroScan, diet, and microbiota: A large cross-sectional study. Tateda T, Iino C, Sasada T, et al. Blautia PubMed ↗
Review Frontiers of medicine · 2022 Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives. Han Y, Li L, Wang B Akkermansia muciniphila PubMed ↗
Observational World journal of gastroenterology · 2022 Gut dysbiosis and small intestinal bacterial overgrowth as independent forms of gut microbiota disorders in cirrhosis. Maslennikov R, Ivashkin V, Efremova I, et al. Blautia PubMed ↗
Review Acta clinica Croatica · 2022 ASSOCIATION BETWEEN PERIODONTITIS AND LIVER DISEASE. Rinčić G, Gaćina P, Virović Jukić L, et al. Porphyromonas PubMed ↗
Observational AIDS · 2022 A pilot study of microbial signatures of liver disease in those with HIV mono-infection in Rio de Janeiro, Brazil. Yanavich C, Perazzo H, Li F, et al. Agathobacter rectalisAkkermansia muciniphilaBacteroides fragilisBacteroides stercoris +5 more PubMed ↗
Randomized trial Journal of hepatology · 2021 Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial. Patel VC, Lee S, McPhail MJW, et al. Veillonella atypicaHungatella PubMed ↗
Randomized trial Nutrients · 2021 The Effect of Probiotics (MCP® BCMC® Strains) on Hepatic Steatosis, Small Intestinal Mucosal Immune Function, and Intestinal Barrier in Patients with Non-Alcoholic Fatty Liver Disease. Mohamad Nor MH, Ayob N, Mokhtar NM, et al. BifidobacteriumLactobacillus PubMed ↗
Observational Gut microbes · 2021 Multiple bacterial virulence factors focused on adherence and biofilm formation associate with outcomes in cirrhosis. Bajaj JS, Shamsaddini A, Acharya C, et al. EnterococcusEscherichiaKlebsiellaStaphylococcus +1 more PubMed ↗
NPJ biofilms and microbiomes · 2026 Megamonas hypermegale with indole-3-lactic acid-producing capacity ameliorates hepatic fibrosis. Zhang L, Chen J, Huang W, et al. Megamonas PubMed ↗
Frontiers in cellular and infection microbiology · 2026 Integrated microbial and transcriptomic profiling reveals distinct correlations in atrophic gastritis associated with liver cirrhosis. Zhu Y, Zhang G, Ma R, et al. Veillonella PubMed ↗
Gut microbes · 2026 Phocaeicola coprocola attenuates liver fibrosis by modulating extracellular matrix remodeling. Lee KJ, Park JH, Park H, et al. Phocaeicola PubMed ↗
MicrobiologyOpen · 2026 Effects of Different Living Environments on Intestinal Flora in Patients With Schistosoma Japonicum-Induced Liver Fibrosis. Fan X, Zhou C, Zhang P, et al. Blautia PubMed ↗
Phytomedicine · 2026 A water-soluble Dendrobium officinale polysaccharide (DOPW) attenuates hepatic fibrosis via gut microbiota-mediated autophagy activation. Zhu Y, Ding X, Wang X, et al. ParabacteroidesPrevotella PubMed ↗
United European gastroenterology journal · 2026 Clinical and Mechanistic Association Between Intestinal Permeability and the Gut Microbiome in Cirrhosis: Role of Phascolarctobacterium. Haller R, Feldbacher N, Fürst S, et al. Phascolarctobacterium PubMed ↗