Cellular and molecular life sciences · 2026 Renal fibrosis is induced by hyperactive Wnt/β-catenin pathway via microbial-mediated tryptophan metabolism-driven AhR signaling in rodents and humans. Liu L, Yu QQ, Zhang YL, et al. Enterocloster aldenensis PubMed ↗
Phytomedicine · 2025 Fucoidan alleviates renal fibrosis in mice via Akkermansia muciniphila-mediated suppression of NEU1-TLR4-NFκB signaling axis. Wang Z, Rong XL, Dai CX, et al. Akkermansia muciniphila PubMed ↗
Animal study Phytomedicine · 2026 A microbiota-tryptophol-AhR axis mediates the gut-kidney protective effects of Hushen Tongfengtai Granules in hyperuricemic nephropathy. Ling GC, Chen SJ, Li ZL, et al. Bifidobacterium breve PubMed ↗
Animal study Journal of periodontology · 2025 Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis. Nobre ÁVV, Silva PHF, Del-Arco MCG, et al. Bifidobacterium animalis PubMed ↗
Animal study Nature communications · 2022 The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice. Zhou W, Wu WH, Si ZL, et al. Bacteroides fragilis PubMed ↗
Randomized trial Nutritional neuroscience · 2019 Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Haghighat N, Rajabi S, Mohammadshahi M Bifidobacterium animalisBifidobacterium bifidumBifidobacterium longum PubMed ↗