Clinical trial Translational psychiatry · 2026 Multi-strain probiotic intervention in adults with depressive and anxiety symptoms: A 12-Week pilot study. Ovadia YS, Okal T, Gefel D, et al. Bifidobacterium animalis PubMed ↗
Randomized trial BMC psychiatry · 2026 Exploring brain-gut interaction mechanisms in Transcutaneous auricular Vagus Nerve stimulation for Major Depressive Disorder. Ma Y, Sun J, Guo C, et al. Faecalibacterium prausnitzii PubMed ↗
Observational CNS neuroscience & therapeutics · 2026 Continuous Alterations in the Gut Microbial Landscape Associated With Suicidal Ideation in First-Episode Drug-naïve Major Depressive Disorder. Liang L, Chen S, Zhu B, et al. Bacteroides eggerthiiBacteroides stercorisBifidobacterium pseudocatenulatumFaecalibacillus intestinalis PubMed ↗
Observational Journal of affective disorders · 2026 Integrative multi-kingdom gut microbiome analysis uncovers clinical signatures of major depressive disorder. Chen S, Zhu B, Lu X, et al. Bifidobacterium pseudocatenulatum PubMed ↗
Observational mSystems · 2026 Gut microbiome signatures associated with depression and obesity. Mora-Martínez C, Molina-Mendoza G, Cenit MC, et al. Faecalibacterium prausnitzii PubMed ↗
Randomized trial Gut microbes · 2025 Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls. Mörkl S, Narrath M, Schlotmann D, et al. Akkermansia muciniphila PubMed ↗
Observational Psychoneuroendocrinology · 2024 Comparative analysis of gut microbiota in major depressive disorder and schizophrenia during hospitalisation - the case-control, post hoc study. Misera A, Kaczmarczyk M, Łoniewski I, et al. [Ruminococcus] torques PubMed ↗
Randomized trial Scientific reports · 2024 Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Strodl E, Bambling M, Parnam S, et al. Bifidobacterium bifidumStreptococcus thermophilus PubMed ↗
Randomized trial Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022 Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial. Ullah H, Di Minno A, Esposito C, et al. Bifidobacterium longum PubMed ↗
Review Nutrients · 2022 Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases. Eicher TP, Mohajeri MH Agathobacter rectalis PubMed ↗
Observational Nature genetics · 2022 Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. Qin Y, Havulinna AS, Liu Y, et al. Enterococcus faecalis PubMed ↗
Randomized trial Brain, behavior, and immunity · 2021 Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Tian P, Chen Y, Zhu H, et al. Bifidobacterium breve PubMed ↗
International immunopharmacology · 2026 Faecalibacterium prausnitzii attenuates diabetes-associated affective disorders by suppressing neuroinflammation through the SCFAs/FFAR3/NF-κB/NLRP3 pathway. Zhang Y, Mo D, Huang Q, et al. Faecalibacterium prausnitzii PubMed ↗
Annals of the rheumatic diseases · 2026 An immunometabolic signature of major depressive disorder in systemic lupus erythematosus. Ellul P, Tchitchek N, Kvedaraviciute G, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Acta neuropsychiatrica · 2026 Functional shotgun metagenomic insights into gut microbial pathway and enzyme disruptions linking metabolism, affect, cognition, and suicidal ideation in major depressive disorder. Maes M, Almulla AF, Vasupanrajit A, et al. Anaerobutyricum halliiFaecalibacterium prausnitziiMediterraneibacter gnavusVescimonas coprocola PubMed ↗
Journal of microbiology and biotechnology · 2026 Integrated Microbiome and Metabolomic Profiling to Identify Potential Biomarkers of Major Depressive Disorder. Lee H, Lee MH, Seo SH, et al. Lachnospira eligens PubMed ↗
mBio · 2025 Gut microbiota dysbiosis and metabolic perturbations of bile/glyceric acids in major depressive disorder with IBS comorbidity. Du J-Y, Zhang Z-J, Tan L, et al. [Clostridium] scindensEggerthella lenta PubMed ↗
Omics · 2025 Alterations in Gut Microbiota-Brain Axis in Major Depressive Disorder as Identified by Machine Learning. Oncu AD, Ozgur A, Ulgen KO Bifidobacterium adolescentis PubMed ↗
Journal of psychiatric research · 2024 A further examination of growth factors, T helper 1 polarization, and the gut microbiome in major depression: Associations with reoccurrence of illness, cognitive functions, suicidal behaviors, and quality of life. Maes M, Zhou B, Vasupanrajit A, et al. Parabacteroides distasonis PubMed ↗
Food & function · 2024 Determining the emotional regulation function of Bifidobacterium breve: the role of gut metabolite regulation over colonization capability. Qian X, Tian P, Guo M, et al. Bifidobacterium breve PubMed ↗