Observational Clinical oral investigations · 2026 Novel salivary biomarkers of Alzheimer's disease identified by integrated metabolomics and microbiomics analysis. Chen H, Chen H, Xie L, et al. Klebsiella pneumoniae PubMed ↗
Review Biomolecules · 2026 Akkermansia muciniphila and Alzheimer's Disease: Mechanisms, Evidence and Translational Potential. Li J, Long Q, Zhu B Akkermansia muciniphila PubMed ↗
Systematic review Molecular neurobiology · 2026 Gut Microbiota Dysbiosis and Neuroinflammation in Alzheimer's Disease: a Systematic Review of Mechanistic Insights. Katsigianni S, Koutsouraki E Escherichia coliFaecalibacterium prausnitziiRoseburia hominis PubMed ↗
Observational Journal of Alzheimer's disease · 2026 Association of yoga with cognitive and gut microbiome changes in Alzheimer's disease: An exploratory case-control study. Tiwari P, Gupta A, Kaushik M, et al. Collinsella aerofaciensFaecalibacterium prausnitziiRoseburia intestinalis PubMed ↗
Observational Nutrients · 2026 MIND Pattern Nutritional Intervention Modulates Mediterranean Diet Adherence and Gut Microbiota in Alzheimer's Disease: An Observational Case-Control Study. Di Renzo L, Raffaelli G, Pala B, et al. [Ruminococcus] torquesAgathobacter rectalisAnaerobutyricum hallii PubMed ↗
Review Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025 Microbiota-brain interaction: The role of gut-derived proteins in addressing various neurological disorders including Parkinson's (PD) and Alzheimer's diseases (AD). Taj T, Kaushik M, Islam A, et al. Bifidobacterium longum PubMed ↗
Review Alzheimer's & dementia · 2025 Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential. Rozenblum G, Ait-Aissa K, Zahran G, et al. Streptococcus salivarius PubMed ↗
Randomized trial Journal of translational medicine · 2025 Computerized cognitive training enhances cognitive function in Alzheimer's disease by downregulating Ruminococcus-TMAO pathway. Zhang W, Song J, Zhong F, et al. [Ruminococcus] torques PubMed ↗
Observational Alzheimer's research & therapy · 2025 Gut microbiota characterization in ageing, mild cognitive impairment, and Alzheimer's disease in the context of mediterranean lifestyle in a Spanish population. Cabrera C, Carrión N, Mateo D, et al. Coprococcus comesOdoribacter splanchnicus PubMed ↗
Observational PloS one · 2025 Gut microbiome signatures in iNPH: Insights from a shotgun metagenomics study. Park R, Chevalier C, Kieser S, et al. Enterocloster bolteaeEvtepia gabavorousMediterraneibacter gnavus PubMed ↗
Randomized trial Scientific reports · 2025 Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer's disease: a randomized, double blind, placebo controlled trial. Jouni N, Akhgarjand C, Vahabi Z, et al. Bifidobacterium longum PubMed ↗
Randomized trial Journal of Alzheimer's disease · 2025 Effect of the probiotic Escherichia coli Nissle 1917 on serum levels of NADPH oxidase-2 and lipopolysaccharide in patients with Alzheimer's disease. Loffredo L, Alfano AR, Ettorre E, et al. Escherichia coli PubMed ↗
Review Trends in neurosciences · 2025 The multifaceted roles of Akkermansia muciniphila in neurological disorders. Ma X, Liu Q, Yang G Akkermansia muciniphila PubMed ↗
Review Nutrients · 2025 Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer's Disease. Abdelhamid M, Counts SE, Zhou C, et al. Bifidobacterium breve PubMed ↗
Systematic review Nutrients · 2025 Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review. Reiriz M, Beltrán-Velasco AI, Echeverry-Alzate V, et al. Bifidobacterium breveBifidobacterium longum PubMed ↗
Observational Alzheimer's research & therapy · 2024 Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer's disease. Qiu C, Zhou W, Shen H, et al. Veillonella parvula PubMed ↗
Randomized trial Inflammopharmacology · 2024 The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Akhgarjand C, Vahabi Z, Shab-Bidar S, et al. Bifidobacterium longum PubMed ↗
Observational Current Alzheimer research · 2024 Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study. Yu B, Wan G, Cheng S, et al. Bacteroides ovatusBifidobacterium adolescentisRoseburia inulinivorans PubMed ↗
Randomized trial Nutrients · 2023 Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer's Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study. Hsu YC, Huang YY, Tsai SY, et al. Bifidobacterium bifidumBifidobacterium longum PubMed ↗
Meta-analysis Scientific reports · 2023 Genetic correlations between Alzheimer's disease and gut microbiome genera. Cammann D, Lu Y, Cummings MJ, et al. Faecalicatena fissicatena PubMed ↗
Review International journal of molecular sciences · 2022 Lipopolysaccharides (LPSs) as Potent Neurotoxic Glycolipids in Alzheimer's Disease (AD). Zhao Y, Jaber VR, Pogue AI, et al. Bacteroides fragilis PubMed ↗
Review Nutrients · 2022 Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases. Eicher TP, Mohajeri MH Agathobacter rectalis PubMed ↗
Observational Journal of Alzheimer's disease · 2021 The Alzheimer-E. coli Axis: What Can We Learn from an Electronic Health Record Platform. Katz J, Gao H Escherichia coli PubMed ↗
Gut microbes · 2026 Personalized whole-body modeling links gut microbiota to metabolic perturbations in Alzheimer's disease. Hensen T, Khatib L, Patel L, et al. Bacteroides uniformis PubMed ↗
Cell reports · 2026 A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models. Zuffa S, Allaband C, Charron-Lamoureux V, et al. Akkermansia muciniphila PubMed ↗
Cell reports. Medicine · 2026 Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles. Xie J, Dai XJ, Li Q, et al. Escherichia coli PubMed ↗
Journal of agricultural and food chemistry · 2026 Goat Milk Fat Globule Membrane Supplementation Ameliorates Alzheimer Disease Cognitive Impairment by Modulating the Gut Microbiota. Li H, Zhao Y, Luo Y, et al. Dorea formicigenerans PubMed ↗
Letters in applied microbiology · 2026 Altered gut microbiota, SCFAs, and barrier integrity markers in Alzheimer's and Parkinson's disease patients. Ahmadi S, Hasani A, Yasdchi M, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Cell systems · 2026 Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility. Blackmer-Raynolds L, Lipson LD, Kozlov A, et al. Escherichia coli PubMed ↗
European archives of psychiatry and clinical neuroscience · 2026 Genetic evidence on chemical communication between gut microbiota and neurological and psychiatric disorders: a Mendelian randomization study. Yu S, Ye Z, Zhao W, et al. [Ruminococcus] torques PubMed ↗
Alzheimer's research & therapy · 2026 Dysbiotic shift in the oral microbiota of patients with Alzheimer's disease compared to their healthy life partners-a combinatorial approach and a paired study design. Weber C, Wind D, Petzsch P, et al. Dialister invisusStreptococcus parasanguinis PubMed ↗
Biomolecules · 2025 Gut Microbial Composition and Short-Chain Fatty Acid Metabolism in Cognitively Unimpaired Adults Stratified by Amyloid-β Status. Dissanayaka DMS, Jayasinghe TN, Sohrabi HR, et al. Bacteroides ovatusBacteroides thetaiotaomicronBifidobacterium animalisFaecalibacterium prausnitzii PubMed ↗
Alzheimer's research & therapy · 2025 Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease. Son SJ, Wu X, Roh HW, et al. Anaerobutyricum halliiAnaerostipes hadrus PubMed ↗
Alzheimer's research & therapy · 2025 Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer's disease pathology. Fan KC, Lin CC, Chiu YL, et al. Akkermansia muciniphila PubMed ↗
European journal of nuclear medicine and molecular imaging · 2025 [18F]flutemetamol uptake in the colon of a memory clinic population and its association with brain amyloidosis and the gut microbiota profile: an exploratory study. Quattrini G, Gatti E, Peretti DE, et al. Anaerobutyricum hallii PubMed ↗
BMC neurology · 2025 Association between sphingomyelin levels and gut microbiota abundance in Alzheimer's disease: a two-sample Mendelian randomization study. Wang L, Ding Y, Tang Y, et al. Bacteroides caccaeHaemophilus parainfluenzaeRuminococcus callidus PubMed ↗
Microbiome · 2025 Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer's disease pathologic process via GPR41 and GPR43. Wang Z, Wang C, Yuan B, et al. Akkermansia muciniphila PubMed ↗
Nutrients · 2024 Bidirectional Two-Sample, Two-Step Mendelian Randomisation Study Reveals Mediating Role of Gut Microbiota Between Vitamin B Supplementation and Alzheimer's Disease. An Y, Cao Z, Du Y, et al. Eubacterium ventriosum PubMed ↗
Cell metabolism · 2024 Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis. Zha X, Liu X, Wei M, et al. Bacteroides ovatus PubMed ↗
Molecular diversity · 2024 Exploring bacterial metabolites in microbe-human host dialogue and their therapeutic potential in Alzheimer's diseases. Singh SD, Bharali P, Nagamani S Alistipes indistinctusBacteroides ovatusBacteroides uniformisParaprevotella clara PubMed ↗