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Multiple sclerosis

Compared within 2 studies that had both: 113 people with multiple sclerosis and 116 healthy people. 20 microbes are less common in people with multiple sclerosis, and 15 more common.

A difference is an association: it doesn’t mean these microbes cause, prevent or treat multiple sclerosis.

Phylum

Searching opens both lists and shows only matching rows.

Less common in multiple sclerosis · 20

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people
  1. Lacrimispora amygdalina in 2 studies Healthy 75% multiple sclerosis 40%
  2. Rikenellaceae bacterium in 2 studies Healthy 11% multiple sclerosis 0%
  3. Faecalicatena fissicatena in 2 studies Healthy 59% multiple sclerosis 27%
  4. Alistipes communis in 2 studies Healthy 61% multiple sclerosis 30%
  5. Bacteroidales bacterium in 2 studies Healthy 8.6% multiple sclerosis 0%

More common in multiple sclerosis · 15

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people
  1. Hungatella hathewayi in 2 studies Healthy under 1% multiple sclerosis 32%
  2. Eggerthella lenta in 2 studies Healthy 26% multiple sclerosis 66%
  3. Ruthenibacterium lactatiformans in 2 studies Healthy 58% multiple sclerosis 90%
  4. Longicatena caecimuris in 2 studies Healthy 3.4% multiple sclerosis 29%
  5. Thomasclavelia spiroformis in 2 studies Healthy 5.8% multiple sclerosis 33%

As many carry these · 4 the amount differs

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people
  1. Blautia wexlerae in 2 studies Healthy 97% multiple sclerosis 100%

    Carriers have about twice as much, in 2 of 2 studies (0.42% → 0.95% of their gut microbes).

  2. Blautia faecis in 2 studies Healthy 90% multiple sclerosis 98%

    Carriers have about twice as much, in 2 of 2 studies (0.13% → 0.26% of their gut microbes).

  3. Anaerobutyricum hallii in 2 studies Healthy 85% multiple sclerosis 85%

    Carriers have more, in 2 of 2 studies (0.23% → 0.32% of their gut microbes).

Where these numbers come from

Studies
Only GMrepo projects that had people with the condition and healthy people, 10 or more of each. Numbers come from those studies, never from pooling.Sampled in Canada, the United States.
How common
The share of people whose sample has any of it, in the people with the condition and in the healthy people of those same studies. Tested within studies (Cochran–Mantel–Haenszel, corrected for testing many microbes); a difference counts when it is clear and meaningful (Cohen’s h of 0.2 or more).
Strength word
Counted by code from how many studies point the same way: Seen again and again (3 or more, none clearly the other way), Seen more than once (2, the majority), Seen once (1, listed last). Where studies disagree, a row isn’t listed.
Each study
Tap a row for every study’s own numbers, and for how much carriers have.
Analysis
Our analysis of GMrepo data. GMrepo on Data sources · Read the rules

Also compared · 227 microbes

Compared within studies that had both, but not listed above.

Studies disagree · 26

No meaningful difference · 201
PubMed · human studies and reviews first

Recent research

All research on it
  1. Systematic review Antonie van Leeuwenhoek · 2026
    Faecalibacterium prausnitzii and Akkermansia muciniphila: driving the multiple sclerosis-a systematic review.
    PubMed ↗
  2. Review Brain and behavior · 2026
    Modulating the Gut Microbiome as a Therapeutic Approach in Multiple Sclerosis: Implications for Gut-Brain Interactions and Immune Pathways: A Narrative Review.
    PubMed ↗
  3. Observational Scientific reports · 2025
    Gut dysbiosis in multiple sclerosis patients: a comparative analysis in fecal samples.
    PubMed ↗
  4. Systematic review Multiple sclerosis and related disorders · 2024
    The multiple sclerosis gut microbiome and disease activity: A systematic review.
    PubMed ↗
  5. Randomized trial European journal of sport science · 2024
    Impact of dance classes on motor and cognitive functions and gut microbiota composition in multiple sclerosis patients: Randomized controlled trial.
    PubMed ↗

Source: PubMed, U.S. National Library of Medicine · 34 linked papers, last 10 years