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Cystic fibrosis

Compared within 1 study that had both: 52 people with cystic fibrosis and 50 healthy people. 86 microbes are less common in people with cystic fibrosis, and 11 more common.

A difference is an association: it doesn’t mean these microbes cause, prevent or treat cystic fibrosis.

Phylum

Searching opens both lists and shows only matching rows.

Less common in cystic fibrosis · 86

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people
  1. Bacteroides xylanisolvens in 1 study Healthy 52% cystic fibrosis 0%
  2. Akkermansia muciniphila in 1 study Healthy 48% cystic fibrosis 0%
  3. Waltera acetigignens in 1 study Healthy 48% cystic fibrosis 0%
  4. Ruthenibacterium lactatiformans in 1 study Healthy 70% cystic fibrosis 5.8%
  5. Anaerotruncus colihominis in 1 study Healthy 46% cystic fibrosis 0%

More common in cystic fibrosis · 11

Strongest first, then the biggest gap · Each figure is 10 people Strongest first · Each figure is 10 people
  1. Clostridium perfringens in 1 study Healthy 12% cystic fibrosis 60%
  2. Dialister pneumosintes in 1 study Healthy 0% cystic fibrosis 25%
  3. Finegoldia magna in 1 study Healthy 0% cystic fibrosis 23%
  4. Neisseria subflava in 1 study Healthy 0% cystic fibrosis 21%
  5. Escherichia marmotae in 1 study Healthy 18% cystic fibrosis 60%

Where these numbers come from

Studies
Only GMrepo projects that had people with the condition and healthy people, 10 or more of each. Numbers come from those studies, never from pooling.Sampled in the United States.
How common
The share of people whose sample has any of it, in the people with the condition and in the healthy people of those same studies. Tested within studies (Cochran–Mantel–Haenszel, corrected for testing many microbes); a difference counts when it is clear and meaningful (Cohen’s h of 0.2 or more).
Strength word
Counted by code from how many studies point the same way: Seen again and again (3 or more, none clearly the other way), Seen more than once (2, the majority), Seen once (1, listed last). Where studies disagree, a row isn’t listed.
Each study
Tap a row for every study’s own numbers, and for how much carriers have.
Analysis
Our analysis of GMrepo data. GMrepo on Data sources · Read the rules

Also compared · 109 microbes

Compared within studies that had both, but not listed above.

No meaningful difference · 109
PubMed · human studies and reviews first

Recent research

All research on it
  1. Journal of bacteriology · 2026
    A genotoxin associated with colorectal cancer linked to gut dysbiosis in children with cystic fibrosis.
    PubMed ↗
  2. Microbiology spectrum · 2026
    The regional landscape of the human colon culturome in health and cystic fibrosis.
    PubMed ↗
  3. Journal of cystic fibrosis · 2026
    Parallel metagenomic- and culture-based approaches show nasal swabs are a good proxy for broncho-alveolar lavage in children with cystic fibrosis.
    PubMed ↗
  4. Observational Journal of cystic fibrosis · 2025
    Fecal microbiota changes in people with cystic fibrosis after 6 months of elexacaftor/tezacaftor/ivacaftor: Findings from the promise study.
    PubMed ↗
  5. Journal of pediatric gastroenterology and nutrition · 2024
    Premodulator microbiome alterations associated with postmodulator growth outcomes in pediatric cystic fibrosis: Can we predict outcomes?
    PubMed ↗

Source: PubMed, U.S. National Library of Medicine · 23 linked papers, last 10 years