Randomized trial Journal of gastroenterology and hepatology · 2026 Consolidation Therapy of Probiotics With Rifaximin Prevent Relapse in Rifaximin-Responsive Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Randomized Clinical Trial. Zhong J, Xu Z, Chen W, et al. Enterococcus faecium PubMed ↗
Randomized trial Nutrients · 2026 Heyndrickxia coagulans IDCC 1201 Alters Gut Microbiome and Metabolome in Patients with Functional Bowel Disorders. Jeon HJ, Moon JS, Jeong HM, et al. [Clostridium] leptumAgathobacter rectalisRuminococcus bromii PubMed ↗
Review Reviews on environmental health · 2026 Dietary patterns, gut microbiota, and gastrointestinal disorders: mechanistic insights into irritable bowel syndrome and inflammatory bowel disease. Khial Y, Lathief S, Aliwi L, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Observational Journal of pediatric gastroenterology and nutrition · 2026 Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls. Santucci NR, Dike CR, Hellmann J, et al. Mediterraneibacter gnavus PubMed ↗
Review International immunopharmacology · 2026 Probiotic therapeutics: A critical review of mechanisms, clinical efficacy, and the frontier of precision microbiome modulation. Ashaolu TJ, Suttikhana I Akkermansia muciniphila PubMed ↗
Randomized trial Journal of gastroenterology and hepatology · 2025 Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial. Ghoshal UC, Ramakrishna BS, Rathi PM, et al. Bifidobacterium animalis PubMed ↗
Review British journal of hospital medicine · 2025 The Role of Colonic Microbiota in Constipation Predominant Irritable Bowel Syndrome: A Literature Review. Roy YJ, Mirani Y, Raju J, et al. Escherichia coli PubMed ↗
Systematic review European journal of gastroenterology & hepatology · 2025 Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis. Rokkas T, Ekmektzoglou K, Tsanou E, et al. Bifidobacterium animalisBifidobacterium longum PubMed ↗
Randomized trial Journal of pediatric gastroenterology and nutrition · 2025 Calcium butyrate efficacy in pediatric irritable bowel syndrome: Randomized placebo-controlled multiomics-based clinical trial. Cristofori F, Calabrese FM, Iacobellis I, et al. Mediterraneibacter gnavus PubMed ↗
Randomized trial Phytomedicine · 2025 Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial. Zhai L, Zheng Y, Lo CW, et al. Agathobacter rectalis PubMed ↗
Observational Journal of molecular medicine · 2025 Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients. Matijašić M, Barešić A, Čipčić Paljetak H, et al. Akkermansia muciniphila PubMed ↗
Randomized trial Nutrients · 2025 Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial. Laterza L, Cremon C, Coppola G, et al. Bifidobacterium animalisStreptococcus thermophilus PubMed ↗
Randomized trial Nutrients · 2024 Effect of Postbiotic Bifidobacterium longum CECT 7347 on Gastrointestinal Symptoms, Serum Biochemistry, and Intestinal Microbiota in Healthy Adults: A Randomised, Parallel, Double-Blind, Placebo-Controlled Pilot Study. Naghibi M, Pont-Beltran A, Lamelas A, et al. Bifidobacterium longum PubMed ↗
Randomized trial Scientific reports · 2024 Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Kwon H, Nam EH, Kim H, et al. Akkermansia muciniphilaBacteroides cellulosilyticus PubMed ↗
Randomized trial NPJ biofilms and microbiomes · 2024 Fecal microbiota transplantation influences microbiota without connection to symptom relief in irritable bowel syndrome patients. Hartikainen AK, Jalanka J, Lahtinen P, et al. Segatella copri PubMed ↗
Observational The American journal of gastroenterology · 2024 Fecal Proteolytic Bacteria and Staphylococcal Superantigens Are Associated With Abdominal Pain Severity in Irritable Bowel Syndrome. Quan R, Decraecker L, Appeltans I, et al. Alistipes putredinisFaecalibacterium prausnitziiParaprevotella clara PubMed ↗
Randomized trial Gut microbes · 2024 Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Martin FP, Cominetti O, Berger B, et al. Bifidobacterium longum PubMed ↗
Randomized trial European journal of nutrition · 2024 Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Gut microbes · 2024 A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Srivastava S, Basak U, Naghibi M, et al. Bifidobacterium longum PubMed ↗
Randomized trial Digestive diseases and sciences · 2024 Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms. El-Salhy M, Hatlebakk JG Streptococcus salivarius PubMed ↗