Interactions › Clostridioides difficile

Clostridioides difficile: its interactions

Everything we hold for this microbe: the microbes it lives with, the metabolites it eats and makes, life factors and health. Click any dot to centre the map on it.

Microbes 15

  • Buchnera aphidicola
    Microbes Recorded only Recorded as making the d-tryptophan, l-leucine and l-methionine C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Bifidobacterium adolescentis
    Microbes Recorded only Recorded as making the biotin and vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Bifidobacterium bifidum
    Microbes Recorded only Recorded as making the biotin and vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Bifidobacterium longum
    Microbes Recorded only Recorded as making the biotin and vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Corynebacterium glutamicum
    Microbes Recorded only Recorded as making the arginine and aspartate C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
    Microbes Recorded only Recorded as able to use the 4-aminobutyrate C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Escherichia coli
    Microbes Recorded only Recorded as making the biotin and l-threonine C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Agrobacterium tumefaciens
    Microbes Recorded only Recorded as able to use the 4-aminobutyrate C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Anaerostipes caccae
    Microbes Recorded only Recorded as able to use the 4-aminobutyrate C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Bacillus subtilis
    Microbes Recorded only Recorded as making the vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
    Microbes Recorded only Recorded as able to use the 4-aminobutyrate C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Bifidobacterium breve
    Microbes Recorded only Recorded as making the vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Ectopseudomonas mendocina
    Microbes Recorded only Recorded as able to use the methylamine C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Klebsiella pneumoniae
    Microbes Recorded only Recorded as able to use the methylamine C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Lactobacillus helveticus
    Microbes Recorded only Recorded as making the vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Ralstonia pickettii
    Microbes Recorded only Recorded as able to use the methylamine C. difficile makes. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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  • Streptococcus thermophilus
    Microbes Recorded only Recorded as making the vitamin b6 C. difficile uses. Records show both handle the same compound, not that one feeds the other in a gut. NJC19 records Oct 2026
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Metabolites 46

  • 4-Hydroxyproline
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
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  • Butyrate
    Metabolites · Makes From genomes (AGORA2) 27 of 27 strains Made or used by most gut microbes we hold (48 species), so it doesn't link microbes on its own. Genome analysis (AGORA2) Oct 2026
    Metabolites · Makes Recorded only Papers say yes Made or used by most gut microbes we hold (48 species), so it doesn't link microbes on its own. NJC19 records NJC19 ref 40 Oct 2026
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  • D-Sorbitol
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 348 Oct 2026
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  • Fructose
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Made or used by most gut microbes we hold (79 species), so it doesn't link microbes on its own. Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only 1 of 1 strain Made or used by most gut microbes we hold (79 species), so it doesn't link microbes on its own. BacDive lab tests
    Metabolites · Eats Recorded only Papers say yes Made or used by most gut microbes we hold (79 species), so it doesn't link microbes on its own. NJC19 records NJC19 ref 348 Oct 2026
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  • Glucose
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Made or used by most gut microbes we hold (152 species), so it doesn't link microbes on its own. Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only 6 of 12 strains Made or used by most gut microbes we hold (152 species), so it doesn't link microbes on its own. BacDive lab tests
    Metabolites · Eats Recorded only Papers say yes Made or used by most gut microbes we hold (152 species), so it doesn't link microbes on its own. NJC19 records NJC19 ref 192NJC19 ref 348 Oct 2026
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  • Glycine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-aspartate
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-isoleucine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192NJC19 ref 678 Oct 2026
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  • L-methionine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-phenylalanine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-proline
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192NJC19 ref 678 Oct 2026
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  • L-serine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-threonine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-valine
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192NJC19 ref 678 Oct 2026
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  • Lactate
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Made or used by most gut microbes we hold (107 species), so it doesn't link microbes on its own. Genome analysis (AGORA2) Oct 2026
    Metabolites · Makes From genomes (AGORA2) 27 of 27 strains Made or used by most gut microbes we hold (107 species), so it doesn't link microbes on its own. Genome analysis (AGORA2) Oct 2026
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  • Pyruvate
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
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  • Stachyose
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 348 Oct 2026
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  • Stickland reaction
    Metabolites · Eats From genomes (AGORA2) 27 of 27 strains Genome analysis (AGORA2) Oct 2026
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  • Esculin
    Metabolites · Eats Recorded only 10 of 16 strains BacDive lab tests
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  • D-mannitol
    Metabolites · Eats Recorded only 5 of 12 strains Made or used by most gut microbes we hold (47 species), so it doesn't link microbes on its own. BacDive lab tests
    Metabolites · Eats Recorded only Papers say yes Made or used by most gut microbes we hold (47 species), so it doesn't link microbes on its own. NJC19 records NJC19 ref 348 Oct 2026
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  • D-mannose
    Metabolites · Eats Recorded only 5 of 27 strains Made or used by most gut microbes we hold (87 species), so it doesn't link microbes on its own. BacDive lab tests
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  • Gelatin
    Metabolites · Eats Recorded only 4 of 11 strains BacDive lab tests
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  • Melezitose
    Metabolites · Eats Recorded only 4 of 13 strains BacDive lab tests
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  • Nitrate
    Metabolites · Eats Recorded only 3 of 33 strains BacDive lab tests
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  • Nitrite
    Metabolites · Eats Recorded only 3 of 7 strains BacDive lab tests
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  • L-Leucine
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192NJC19 ref 678 Oct 2026
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  • L-Tryptophan
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192NJC19 ref 678 Oct 2026
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  • Salicin
    Metabolites · Eats Recorded only 2 of 13 strains BacDive lab tests
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  • Trehalose
    Metabolites · Eats Recorded only 2 of 12 strains Made or used by most gut microbes we hold (56 species), so it doesn't link microbes on its own. BacDive lab tests
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  • 4-Aminobutyrate
    Metabolites · Makes Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • 5-Aminovalerate
    Metabolites · Makes Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • Acetate
    Metabolites · Makes Recorded only Papers say yes Made or used by most gut microbes we hold (120 species), so it doesn't link microbes on its own. NJC19 records NJC19 ref 710 Oct 2026
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  • Biotin
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 678 Oct 2026
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  • L-Alanine
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-Arginine
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-Cysteine
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 678 Oct 2026
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  • L-Histidine
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • L-Tyrosine
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 192 Oct 2026
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  • Methylamine
    Metabolites · Makes Recorded only Papers say yes NJC19 records NJC19 ref 98 Oct 2026
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  • N-Acetylneuraminic acid
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 347 Oct 2026
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  • P-Cresol
    Metabolites · Makes Recorded only Papers say yes NJC19 records NJC19 ref 349 Oct 2026
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  • Pantothenic acid
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 678 Oct 2026
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  • Raffinose
    Metabolites · Eats Recorded only Papers say yes Made or used by most gut microbes we hold (75 species), so it doesn't link microbes on its own. NJC19 records NJC19 ref 348 Oct 2026
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  • Taurocholate
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 348 Oct 2026
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  • Vitamin B6
    Metabolites · Eats Recorded only Papers say yes NJC19 records NJC19 ref 678 Oct 2026
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  • Xylose
    Metabolites · Eats Recorded only 1 of 12 strains Made or used by most gut microbes we hold (55 species), so it doesn't link microbes on its own. BacDive lab tests
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6 metabolites it can't eat Genome analysis (AGORA2)
Inulin Its genomes can't eat it· 0 of 27 genomes
Resistant starch Its genomes can't eat it· 0 of 27 genomes
Starch Its genomes can't eat it· 0 of 27 genomes
Pectin Its genomes can't eat it· 0 of 27 genomes
Lactose Its genomes can't eat it· 0 of 27 genomes
Gut mucus Its genomes can't eat it· 0 of 27 genomes
Nothing found isn't proof of no link: a study can miss a small difference.
17 metabolites it can't make Genome analysis (AGORA2)
Propionate Its genomes can't make it· 0 of 27 genomes
Succinate Its genomes can't make it· 0 of 27 genomes
Secondary bile acids Its genomes can't make it· 0 of 27 genomes
Thiamin Its genomes can't make it· 0 of 27 genomes
Riboflavin Its genomes can't make it· 0 of 27 genomes
Niacin Its genomes can't make it· 0 of 27 genomes
and 11 more Nothing found isn't proof of no link: a study can miss a small difference.

Life factors 0

3 diets compared, nothing found Studies whose tables list every microbe they tested
Omnivore Compared, no clear difference· Fackelmann 2025
Vegan Compared, no clear difference· Fackelmann 2025
Vegetarian Compared, no clear difference· Fackelmann 2025
Nothing found isn't proof of no link: a study can miss a small difference.

Health 3

  • ↑ Ulcerative colitis
    Health · Condition Compared within datasets · Seen again and again More common in people with it GMrepo, compared within datasets PRJEB42155PRJEB76677PRJNA398089PRJNA429990PRJNA813736PRJNA983946 and 1 more Oct 2026
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  • ↑ Neuroblastoma
    Health · Condition Compared within datasets · Seen more than once More common in people with it GMrepo, compared within datasets PRJEB63351PRJNA716780 Oct 2026
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  • ↑ Clostridium infections
    Health · Condition Compared within datasets · Seen once More common in people with it GMrepo, compared within datasets PRJNA648321 Oct 2026
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4 conditions compared, nothing found Our analysis of GMrepo data
Chronic kidney failure Compared, no clear difference· 2 studies
Atopic dermatitis Compared, no clear difference· 1 study
Cystic fibrosis Compared, no clear difference· 1 study
Diarrhea Compared, no clear difference· 1 study
2 more where datasets disagree are in its In conditions → Nothing found isn't proof of no link: a study can miss a small difference.