Randomized trial Nutricion hospitalaria · 2025 Effects of probiotic supplementation on blood lipids ın hypercholesterolemic obese patients: a randomized, double-blind, placebo-controlled pilot trial. Bulut S, Kabaran S Bifidobacterium animalisBifidobacterium longumEnterococcus faecium PubMed ↗
Randomized trial NPJ biofilms and microbiomes · 2022 Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils. Lim RRX, Park MA, Wong LH, et al. [Clostridium] leptum PubMed ↗
Review Endocrine, metabolic & immune disorders drug targets · 2022 In vitro Cholesterol Assimilation by Bifidobacterium animalis subsp. lactis (BPL1) Probiotic Bacteria Under Intestinal Conditions. Fernández-Calderón MC, Sánchez-Moro MDH, Rincón EO Bifidobacterium animalis PubMed ↗
Randomized trial Frontiers in immunology · 2021 The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial. Xu D, Feng M, Chu Y, et al. Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Randomized trial Nutrients · 2021 Interactions of Oxysterols with Atherosclerosis Biomarkers in Subjects with Moderate Hypercholesterolemia and Effects of a Nutraceutical Combination (Bifidobacterium longum BB536, Red Yeast Rice Extract) (Randomized, Double-Blind, Placebo-Controlled Study). Cicolari S, Pavanello C, Olmastroni E, et al. Bifidobacterium longum PubMed ↗
Randomized trial Probiotics and antimicrobial proteins · 2021 Efficacy of Probiotic Milk Formula on Blood Lipid and Intestinal Function in Mild Hypercholesterolemic Volunteers: A Placebo-control, Randomized Clinical Trial. Chiu HF, Fang CY, Shen YC, et al. Bifidobacterium animalis PubMed ↗
International journal of molecular sciences · 2023 Differences in Bacterial Small RNAs in Stool Samples from Hypercholesterolemic and Normocholesterolemic Subjects. Morales C, Arias-Carrasco R, Maracaja-Coutinho V, et al. Blautia wexleraeCoprococcus eutactus PubMed ↗
Journal of food biochemistry · 2022 Chrysin reduces hypercholesterolemia-mediated atherosclerosis through modulating oxidative stress, microflora, and apoptosis in experimental rats. Yuvaraj S, Sasikumar S, Puhari SSM, et al. [Clostridium] leptum PubMed ↗
Nutrients · 2021 Evaluation of the Cholesterol-Lowering Mechanism of Enterococcus faecium Strain 132 and Lactobacillus paracasei Strain 201 in Hypercholesterolemia Rats. Yang L, Xie X, Li Y, et al. Enterococcus faecium PubMed ↗
Animal study Brain, behavior, and immunity · 2026 Pre-injury hypercholesterolemia is associated with microbiota-associated neurobehavioral vulnerability following traumatic brain injury. Chen GY, Wee HY, Chiu MH, et al. Akkermansia muciniphila PubMed ↗
Animal study Journal of ethnopharmacology · 2025 A novel cholesterol-reducing mechanism of polygonati rhizoma: Dual action via Bacteroides-mediated cholesterol sulfonation and feedback inhibition of ACAT2 by sulfated metabolite. Wang X, Chen M, Su Y, et al. Bacteroides thetaiotaomicron PubMed ↗
Animal study Nutrients · 2023 Beneficial Effects of Indigenous Probiotics in High-Cholesterol Diet-Induced Hypercholesterolemic Rats. Puttarat N, Kasorn A, Vitheejongjaroen P, et al. Bifidobacterium animalisEnterococcus faecium PubMed ↗
Animal study Nutrients · 2023 Alleviation Syndrome of High-Cholesterol-Diet-Induced Hypercholesterolemia in Mice by Intervention with Lactiplantibacillus plantarum WLPL21 via Regulation of Cholesterol Metabolism and Transportation as Well as Gut Microbiota. Zhao K, Qiu L, He Y, et al. Enterococcus faecium PubMed ↗
Animal study FEMS microbiology letters · 2023 Enterococcus faecium R-026 combined with Bacillus subtilis R-179 alleviate hypercholesterolemia and modulate the gut microbiota in C57BL/6 mice. Huang J, Xu Y, Wang M, et al. Enterococcus faecium PubMed ↗
Animal study International journal of molecular sciences · 2021 Strain-Specific Effects of Bifidobacterium longum on Hypercholesterolemic Rats and Potential Mechanisms. Jiang J, Wu C, Zhang C, et al. Bifidobacterium longum PubMed ↗