Review Microbiological research · 2026 Bacterial extracellular vesicles in the oral-gut axis: Roles in periodontitis and inflammatory bowel disease. He J, Hu H, Huang Y, et al. Akkermansia muciniphila PubMed ↗
Systematic review BMC oral health · 2026 Clinical efficacy of Lactobacillus plantarum and Lactobacillus brevis as adjuncts to professional mechanical plaque removal in periodontitis: a systematic review. Putri RRGA, Sulijaya B, Soeroso Y, et al. Lactiplantibacillus plantarumLevilactobacillus brevis PubMed ↗
Review Biomolecules · 2025 Oral-Gut Microbial Crosstalk and Therapeutic Applications of Bacterial Extracellular Vesicles. Fu W, Yang N, Yan J, et al. Akkermansia muciniphila PubMed ↗
Observational Microbiome · 2025 Periodontitis salivary microbiota exacerbates colitis by CXCL3 derived from gut microbiota-induced macrophages. Qian J, Tao Q, Shen Y, et al. Escherichia coliLacticaseibacillus rhamnosus PubMed ↗
Observational Journal of medical microbiology · 2025 Correlation in the change of gut microbiota with clinical periodontal parameters in grade C periodontitis patients after non-surgical periodontal therapy. Mutafcilar Velioglu E, Arslan U, Kayis SA, et al. Bacteroides PubMed ↗
Randomized trial Oral health & preventive dentistry · 2025 Clinical Effects of Lactobacillus reuteri on Gingival Inflammation and Alveolar Bone Loss in Periodontitis. Lu J, He X, Du T, et al. Limosilactobacillus reuteri PubMed ↗
Randomized trial Journal of clinical periodontology · 2025 Use of the Probiotic Limosilactobacillus reuteri as an Adjunct to Subgingival Instrumentation in the Treatment of Periodontitis Patients With Diabetes: A Randomised Clinical Trial. Bujaldón R, Montero E, Gamonal JD, et al. Limosilactobacillus reuteri PubMed ↗
Randomized trial Clinical oral investigations · 2025 Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial. Mensi M, Scotti E, Marchetti S, et al. Limosilactobacillus reuteri PubMed ↗
Randomized trial BMC oral health · 2025 The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III-IV periodontitis: a randomized controlled trial. Huo P, Deng L, Lu J, et al. Limosilactobacillus reuteri PubMed ↗
Review International journal of molecular sciences · 2024 Oral Pathobiont-Derived Outer Membrane Vesicles in the Oral-Gut Axis. Catalan EA, Seguel-Fuentes E, Fuentes B, et al. Akkermansia muciniphila PubMed ↗
Observational Translational psychiatry · 2024 Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes. Malan-Müller S, Vidal R, O'Shea E, et al. Haemophilus parainfluenzae PubMed ↗
Systematic review European journal of medical research · 2024 Bacteria of healthy periodontal tissues as candidates of probiotics: a systematic review. Del Pilar Angarita-Díaz M, Fong C, Medina D Haemophilus parainfluenzae PubMed ↗
Systematic review Medicina · 2024 Microbiota Transplantation as an Adjunct to Standard Periodontal Treatment in Periodontal Disease: A Systematic Review. Lindo CE, Sebastian J, Kuntjoro KN, et al. Haemophilus parainfluenzae PubMed ↗
Observational Alzheimer's research & therapy · 2024 Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer's disease. Qiu C, Zhou W, Shen H, et al. Veillonella parvula PubMed ↗
Randomized trial Clinical oral investigations · 2024 Effect of adjuvant probiotic therapy (Lactobacillus reuteri) in the treatment of periodontitis associated with diabetes mellitus: clinical, controlled, and randomized study. Jardini MAN, Pedroso JF, Ferreira CL, et al. Limosilactobacillus reuteri PubMed ↗
Meta-analysis Journal of periodontal research · 2023 New putative periodontopathogens and periodontal health-associated species: A systematic review and meta-analysis. Antezack A, Etchecopar-Etchart D, La Scola B, et al. Dialister invisusEnterococcus faecalis PubMed ↗
Randomized trial Clinical advances in periodontics · 2023 A placebo-controlled randomized clinical trial of antibiotics versus probiotics as an adjuvant to nonsurgical periodontal treatment among smokers with Stage III, Grade C generalized periodontitis. Ghazal M, Ahmed S, Farooqui WA, et al. Limosilactobacillus reuteri PubMed ↗
Systematic review International dental journal · 2022 Probiotic Bifidobacteria in Managing Periodontal Disease: A Systematic Review. Matsubara VH, Fakhruddin KS, Ngo H, et al. Bifidobacterium animalis PubMed ↗
Observational Frontiers in cellular and infection microbiology · 2022 Features of the oral microbiome in Japanese elderly people with 20 or more teeth and a non-severe periodontal condition during periodontal maintenance treatment: A cross-sectional study. Toyama N, Ekuni D, Yokoi A, et al. Haemophilus parainfluenzae PubMed ↗
Review International journal of molecular sciences · 2022 Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases. Araujo LDC, Furlaneto FAC, da Silva LAB, et al. Bifidobacterium animalis PubMed ↗
Randomized trial Journal of applied oral science · 2022 Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study. Ramos TCS, Boas MLV, Nunes CMM, et al. Limosilactobacillus reuteri PubMed ↗
Review Archives of oral biology · 2021 What do we know about the mechanisms of action of probiotics on factors involved in the pathogenesis of periodontitis? A scoping review of in vitro studies. Routier A, Blaizot A, Agossa K, et al. Lacticaseibacillus rhamnosusLimosilactobacillus reuteri PubMed ↗
Observational Journal of periodontology · 2021 Prevalence and antimicrobial susceptibility of Gram-negative bacilli in subgingival biofilm associated with periodontal diseases. Espíndola LCP, Picão RC, Mançano SMCN, et al. Klebsiella pneumoniae PubMed ↗
Review Probiotics and antimicrobial proteins · 2021 Interplay of Microbiota and Citrullination in the Immunopathogenesis of Rheumatoid Arthritis. Alghamdi MA, Redwan EM Segatella copri PubMed ↗
Frontiers in cellular and infection microbiology · 2026 Compatibility of toothpastes with probiotics for periodontal health: an in vitro and ex vivo study. Saghi M, Van Holm W, Zayed N, et al. Limosilactobacillus reuteri PubMed ↗
International journal of molecular sciences · 2026 Epithelial Inflammatory iNOS-Nitrate Axis Enhances P. gingivalis Pathogenicity via V. parvula in Diabetes-Associated Periodontitis. Wei L, Liu H, Shen Z, et al. Veillonella parvula PubMed ↗
Journal of microbiology and biotechnology · 2026 MPRO3 Regulates Macrophage Polarization and Osteoclastogenesis In Vitro and Attenuates Ligature-Induced Alveolar Bone Loss in Periodontitis. Park HJ, Kim TS, Kim MK, et al. Bifidobacterium animalisLacticaseibacillus paracasei PubMed ↗
International journal of molecular sciences · 2026 Effects of Non-Surgical Periodontal Therapy on Dental Plaque Microbiome. Wang Q, Wang BY, Wilus D, et al. Escherichia coli PubMed ↗
NPJ biofilms and microbiomes · 2026 Gut commensal Odoribacter splanchnicus attenuates hyperlipidemic periodontitis via gut-oral metabolic transmission of β-GPA. Xu J, Han Z, Xue Q, et al. Odoribacter splanchnicus PubMed ↗
NPJ biofilms and microbiomes · 2026 Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut-oral axis /Th17/Treg imbalance. Huang Y, Hu Y, Zhao Y, et al. Bacteroides PubMed ↗
Molecular immunology · 2026 Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome. Lyu J, Wu M, Wei W, et al. Klebsiella pneumoniae PubMed ↗
NPJ systems biology and applications · 2026 Ecological and stochastic determinants of the growth and persistence of the oral pathogen Porphyromonas gingivalis. Hussein M, Barua A, Qasaimeh M, et al. Veillonella parvula PubMed ↗
International journal of oral science · 2026 Engineered Lactobacillus reuteri for scavenging reactive oxygen species and modulating oral microflora in periodontitis therapy. Wang Y, Tang Y, Huang Q, et al. Limosilactobacillus reuteri PubMed ↗
EBioMedicine · 2025 Periodontitis exacerbates metabolic dysfunction-associated steatotic liver disease via the gut microbiota-derived tryptophan metabolism-AHR axis in obesity. Chen R, Qian J, Wang Q, et al. Limosilactobacillus reuteri PubMed ↗
Clinical oral investigations · 2025 The site-specific subgingival microbiome across periodontal conditions and its relationship with clinical parameters. Chen K, Ren X, Du R, et al. Haemophilus parainfluenzae PubMed ↗
Biomaterials · 2025 A triple-responsive nanozyme platform of AgAu-CeO2 heterojunction integrated with probiotics for precision antibacterial therapy in periodontitis. Li M, Ding Q, Hu S, et al. Limosilactobacillus reuteri PubMed ↗
Circulation · 2025 Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells. Chen BY, Zhu H, Li YL, et al. Phocaeicola plebeius PubMed ↗
Applied microbiology and biotechnology · 2025 Signature of oral microbial dysbiosis in different periodontitis risk levels. Xu Y, Liu Y, Leng Y, et al. Klebsiella pneumoniae PubMed ↗
Nutrients · 2025 Postbiotics Derived from Lactococcus lactis and Streptococcus thermophilus Attenuate Experimental Periodontitis by Modulating Macrophage Polarization and Osteoclastogenesis. Park HJ, Kim MK, Heo SC, et al. Lactococcus lactisStreptococcus thermophilus PubMed ↗
Probiotics and antimicrobial proteins · 2025 Akkermansia muciniphila Alleviates Porphyromonas gingivalis-induced Periodontal Disease by Enhancing Bacterial Clearance. Hu Q, Leung WK, Acharya A, et al. Akkermansia muciniphila PubMed ↗