Randomized trial Science advances · 2026 Bifidobacterium animalis subsp. lactis V9 overcomes CYFRA 21-1-linked immunochemotherapy resistance in NSCLC via microbial metabolites. Feng C, Gao G, He Q, et al. Bifidobacterium animalis PubMed ↗
Review Frontiers in immunology · 2026 Microbiome as a prediction of immunotherapy response in lung cancer. Rojas L, Zuluaga J, Cardona AF Akkermansia muciniphilaFaecalibacterium prausnitzii PubMed ↗
Review International journal of biological sciences · 2026 Gut-Lung Microbiota Axis Shapes the Immune Microenvironment and Immunotherapeutic Response in Lung Cancer. Liu Y, Wang S, Xiang X, et al. Akkermansia muciniphila PubMed ↗
Clinical trial Nature medicine · 2026 Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial. Duttagupta S, Messaoudene M, Hunter S, et al. [Clostridium] innocuumEnterocloster citroniae PubMed ↗
Review Frontiers in immunology · 2025 Respiratory microbiome-host interaction on lung carcinogenesis, immunity, and immunotherapy. Wang P, Ge C, Jing X, et al. Escherichia coli PubMed ↗
Review Current microbiology · 2025 Non-small Cell Lung Cancer, Immunotherapy and the Influence of Gut Microbiome. Raziq MF, Manzoor H, Kayani MUR Akkermansia muciniphila PubMed ↗
Review Medicina · 2024 Insights into the Two Most Common Cancers of Primitive Gut-Derived Structures and Their Microbial Connections. Ray A, Moore TF, Naik DSL, et al. Escherichia coli PubMed ↗
Review Archives of microbiology · 2024 Butyrate's (a short-chain fatty acid) microbial synthesis, absorption, and preventive roles against colorectal and lung cancer. Karim MR, Iqbal S, Mohammad S, et al. Agathobacter rectalisFaecalibacterium prausnitzii PubMed ↗
Clinical trial International journal of radiation oncology, biology, physics · 2022 Gut Microbiome Is Associated With the Response to Chemoradiotherapy in Patients With Non-small Cell Lung Cancer. Qiu B, Xi Y, Liu F, et al. Anaerobutyricum hallii PubMed ↗
Observational Cancer causes & control · 2021 Association of oral microbiota with lung cancer risk in a low-income population in the Southeastern USA. Shi J, Yang Y, Xie H, et al. Lactococcus lactis PubMed ↗
Cancer immunology, immunotherapy · 2026 Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer. Chien PY, Cheng WC, Hung CC, et al. Bifidobacterium longum PubMed ↗
Microbiome · 2026 Metagenomics and culturomics reveal the dual role of the gut microbiome in the development of immune-related toxicities and the efficacy of immune checkpoint inhibitors in cancer. Diop K, Benlaïfaoui M, Hunter S, et al. Mediterraneibacter gnavus PubMed ↗
Gut microbes · 2026 Gut microbiota-associated nutritional-immune status predicts prognosis in postoperative NSCLC patients. Yu Q, Chen A, Yi J, et al. Anaerobutyricum hallii PubMed ↗
Journal of translational medicine · 2026 Distinct gut virome profiles are associated with response to anti-PD-1 therapy in non-small cell lung cancer. Liu Z, Liu M, Chen H, et al. Akkermansia muciniphila PubMed ↗
BMC microbiology · 2026 A real-world evidence of sputum microbiota alterations and their association with oncogenomic changes and response to targeted therapies in patients with lung cancer. Li T, Ye ZL, Yang XH, et al. Klebsiella pneumoniae PubMed ↗
Med · 2025 Gut microbiota predictive of the efficacy of consolidation immunotherapy and chemoradiotherapy toxicity in lung cancer. Wu L, Li Y, Wang W, et al. Akkermansia muciniphila PubMed ↗
Advanced science · 2025 Intravenous iRGD-Guided, RBC-Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD-1 Blockade. Chen C, Zhu J, Liu X, et al. Lactococcus lactis PubMed ↗
International journal of biological macromolecules · 2025 Akkermansia muciniphila-derived outer membrane protein Amuc_1100 promotes acetylation of RING Finger Protein 181 promoter and mediates Autophagy Related 7 ubiquitination to activate CD8+ T cells in lung adenocarcinoma. Xu Y, Qian T, Pan H, et al. Akkermansia muciniphila PubMed ↗
Journal for immunotherapy of cancer · 2025 Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA. Sun S, Wang L, Cui K, et al. Akkermansia muciniphila PubMed ↗
Frontiers in immunology · 2025 Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression. Shimizu T, Ohkuma R, Homma M, et al. Akkermansia muciniphila PubMed ↗